The role of μ-opioid receptors in inflammatory hyperalgesia and α2-adrenoceptor-mediated antihyperalgesia

Neuroscience

Volumn 113, Issue 2, 2002, Pages 339-349

  Mansikka, H ^a   Zhou, L ^b   Donovan, D M ^b   Pertovaara, A ^c   Raja, S N ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Allodynia; Carrageenan; Dexmedetomidine; Morphine; Pain

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CARRAGEENAN; DEXMEDETOMIDINE; MU OPIATE RECEPTOR;

ARTICLE; BEHAVIOR; CONTROLLED STUDY; HYPERALGESIA; INFLAMMATION; KNOCKOUT MOUSE; MOUSE; NEUROMODULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SPINAL REFLEX; STIMULUS RESPONSE; WILD TYPE;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CARRAGEENAN; DECEREBRATE STATE; DEXMEDETOMIDINE; FOOT; HEAT; HINDLIMB; HYPERALGESIA; IMIDAZOLES; INFLAMMATION; MICE; MICE, KNOCKOUT; NOCICEPTORS; PHYSICAL STIMULATION; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, OPIOID, MU; REFERENCE VALUES;

EID: 0037067997     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00189-6     Document Type: Article

References (40)

1. Interactions of drugs active at opiate receptors and drugs active at α2-receptors on various test systems
2. A positive feedback loop between spinal cord nociceptive pathways and antinociceptive areas of the cat's brainstem
3. Periaqueductal gray stimulation-induced inhibition of nociceptive dorsal horn neurons in rats is associated with the release of norepinephrine, serotonin and amino acids
4. Tonic descending inhibition affects intensity coding of nociceptive responses of spinal dorsal horn neurones in the cat
5. Central nervous system mechanisms of pain modulation
6. Inhibition and excitation of primate spinothalamic tract neurons by stimulation in region of nucleus reticularis gigantocellularis
7. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
8. Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue
9. Peripheral opioid modulation of pain and inflammation in the formalin test
10. The analgesic effects of supraspinal μ and δ opioid receptor agonists are potentiated during persistent inflammation
11. Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: A possible involvement of noradrenergic mechanisms
12. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specificity, behavioral parameters and opioid receptor binding
13. Antinociceptive actions of dexmedetomidine and the kappa-opioid agonist U-50488H against noxious thermal, mechanical and inflammatory stimuli
14. Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia
15. Influence of spinalization on spinal withdrawal reflex responses varies depending on the submodality of the test stimulus and the experimental pathophysiological condition in the rat
16. Behavioural evidence for a peripheral component in the enhanced antinociceptive effect of a low dose of systemic morphine in carrageenin-induced hyperalgesic rats
17. The analgesic effect of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in the arthritic rat
18. Tonic descending influences on receptive field properties of nociceptive dorsal horn neurones in sacral spinal cord of rat
19. Transgenic studies of pain and analgesia: Mutation or background genotype?
20. Peripheral effects of the kappa-opioid agonist EMD 61753 on pain and inflammation in rats and humans
21. Influence of selective α2-adrenergic agents on mustard oil-induced central hyperalgesia in rats
22. Supraspinal influence on hindlimb withdrawal thresholds and mustard oil-induced secondary allodynia in rats
23. Inflammation of the hind limb as a model of unilateral, localized pain: Influence on multiple opioid systems in the spinal cord of the rat
24. Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception
25. Antinociceptive interactions between α2-adrenergic and opiate agonists at the spinal level in rodents
26. Involvement of alpha-2 adrenoceptors in the periaqueductal gray-induced inhibition of dorsal horn cell activity in rats
27. Enhanced δ-opioid receptor-mediated antinociception in μ-opioid receptor-deficient mice
28. Enhanced descending modulation of nociception in rats with persistent hindpaw inflammation
29. Interleukin 1β and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue
30. Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia
31. Enhanced α2-adrenergic controls and spinal morphine potency in inflammation
32. Alterations in neuronal excitability and the potency of spinal μ, δ, and κ opioids after carrageenan-induced inflammation
33. The control of pain in the peripheral tissue by opioids
34. Antinociceptive effects of μ- and κ-agonists in inflammation are enhanced by a peripheral opioid receptor-specific mechanism
35. α2-adrenoceptor modulation of nociception in rat spinal cord: Location, effects and interactions with morphine
36. Evidence for the involvement of the μ but not δ opioid receptor subtype in the synergistic interaction between opioid and α2-adrenergic antinociception in the rat spinal cord
37. Peripheral and central mechanisms of cutaneous hyperalgesia
38. Supraspinal contributions to hyperalgesia
39. Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord
40. Anatomy and physiology of descending control of nociceptive responses of dorsal horn neurons: Comprehensive review