In vitro activities of the potent, broad-spectrum carbapenem MK-0826 (L- 749,345) against broad-spectrum β-lactamase-and extended-spectrum β- lactamase-producing Klebsiella pneumoniae and Escherichia coli clinical isolates

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 5, 1999, Pages 1170-1176

  Kohler, Joyce ^a   Dorso, Karen L ^a   Young, Katherine ^a   Hammond, Gail G ^a   Rosen, Hugh ^a   Kropp, Helmut ^a   Silver, Lynn L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; BETA LACTAMASE; CARBAPENEM; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; ERTAPENEM; IMIPENEM; MEROPENEM; MONOBACTAM DERIVATIVE; PENICILLIN BINDING PROTEIN; PENICILLIN G;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SYNTHESIS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0032958792     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.5.1170     Document Type: Article

References (29)

1. Barry, A. L., P. C. Fuchs, and S. D. Brown. 1998. In vitro activity of the carbapenem, MK-0826 (L-749,345), and provisional criteria for disk tests, abstr. D-38, p. 138. In Abstracts of the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
2. Bush, K. 1989. Characterization of β-lactamases. Antimicrob. Agents Chemother. 33:259-263.
3. Bush, K., G. A. Jacoby, and A. A. Medeiros. 1995. A functional classification scheme for β-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39:1211-1233.
4. Dorso, K., J. Kohler, L. L. Silver, and H. Kropp. 1996. Bactericidal effect of L-749,345 on Staphylococcus aureus and Serratia marcescens in the presence and absence of human serum, abstr. F-123, p. 121. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
5. Eng, R. H. K., C. Cherubin, S. M. Smith, and F. Buccini. 1985. Inoculum effect of β-lactam antibiotics on Enterobacteriaceae. Antimicrob. Agents Chemother. 28:601-606.
6. Gerckens, L. S., B. A. Pelak, R. Thompson, H. Rosen, and H. Kropp. 1996. Pharmacokinetic evaluation of L-749,345 (ZD-4433), a long-acting parenteral carbapenem, in rodents, abstr. F127, p. 122. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
7. Gill, C. J., J. J. Jackson, L. S. Gerckens, B. A. Pelak, R. K. Thompson, J. G. Sundelof, H. Kropp, and H. Rosen. 1998. In vivo activity and pharmacokinetic evaluation of a novel long-acting carbapenem antibiotic, MK-826 (L-749,345). Antimicrob. Agents Chemother. 42:1996-2001.
8. Gill, C. J., J. J. Jackson, J. G. Sundelof, H. Rosen, and H. Kropp. 1996. In vivo activity of a novel long-acting carbapenem antibiotic, L-749,345, in mouse models of localized and systemic bacterial infections, abstr. F125, p. 121. In Abstracts of the 36th Inlerscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
9. Goldstein, E. J. C., D. M. Citron, and C. E. Cherubin. 1991. Comparison of the inoculum effects of members of the family Enterobacteriaceae on cefoxitin and other cephalosporins, β-lactamase inhibitor combinations, and the penicillin-derived components of these combinations. Antimicrob. Agents Chemother. 35:560-566.
10. Jacoby, G., P. Han, and J. Tran. 1997. Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens. Antimicrob. Agents Chemother. 41:1830-1831.
11. Kohler, J., K. Dorso, B. A. Pelak, L. S. Gerckens, G. G. Hammond, L. L. Silver, and H. Kropp. 1996. In vitro activity of the potent, broad-spectrum carbapenem L-749,345 against BDSβL- and ESβL-producing Escherichia coli and Klebsiella pneumoniae clinical isolates, abstr. F122, p. 121. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
12. Kohler, J., K. Dorso, K. Young, C. Hirsch, L. L. Silver, and H. Kropp. 1996. Evaluation of resistance selection potential of the new carbapenem L-749,345 in β-lactamase-producing Escherichia coli clinical isolates, abstr. F124, p. 121. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
13. Majumdar, A., K. Birk, R. A. Blum, A. M. Cairns, J. Conroy, C. M. Mendel, D. Muson, and J. D. Rogers. 1996. Pharmacokinetics of L-749,345, a carbapenem antibiotic, in healthy male and female volunteers, abstr. F130, p. 122. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
14. Nagata, T., and T. Horiuchi. 1973. Isolation and characterization of a temperature-sensitive amber suppressor mutant of Escherichia coli K12. Mol. Gen. Genet. 123:77-88.
15. National Committee for Clinical Laboratory Standards. 1993. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 3rd ed. p. 13-17. Approved standard M7-A3. National Committee for Clinical Laboratory Standards, Villanova, Pa.
16. Nikaido, H., and S. Normark. 1987. Sensitivity of Escherichia coli to various β-lactams is determined by the interplay of outer membrane permeability and degradation by periplasmic β-lactamases: a quantitative predictive treatment. Mol. Microbiol. 1:29-36.
17. Pelak, B. A., L. S. Gerckens, P. M. Scott, C. Gill, C. Pacholok, L. Lynch, K. Dorso, J. Kohler, D. Shungu, and H. Kropp. 1996. Antibacterial profile of L-749,345 (ZD-4433), a new potent 1-β-methyl carbapenem, abstr. F119, p. 120. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
18. Scott, P. M., C. J. Gill, D. L. Shungu, and H. Kropp. 1996. Comparative in vitro activity of L-749,345 against respiratory tract bacterial pathogens, abstr. F121, p. 121. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
19. Spratt, B. G. 1975. Distinct penicillin-binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Proc. Natl. Acad. Sci. USA 72:2999-3003.
20. Spratt, B. G. 1977. Properties of the penicillin-binding proteins of Escherichia coli K12. Eur. J. Biochem. 72:341-352.
21. Spratt, B. G., and K. D. Cromie. 1988. Penicillin-binding proteins of Gram-negative bacteria. Rev. Infect. Dis. 10:699-711.
22. Sundelof, J. G., C. J. Gill, R. Thompson, H. Rosen, and H. Kropp. 1996. Disposition of an extended half-life carbapenem in rhesus monkeys, chimpanzees and humans, abstr. F128, p. 122. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
23. Sundelof, J. G., R. Hajdu, C. J. Gill, R. Thompson, H. Rosen, and H. Kropp. 1997. Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates. Antimicrob. Agents Chemother. 41:1743-1748.
24. Suzuki, H., Y. Nishimura, and Y. Hirota. 1978. On the process of cellular division in Escherichia coli: a series of mutants of E. coli altered in the penicillin-binding proteins. Proc. Natl. Acad. Sci. USA 75:664-668.
25. Sykes, R. B., D. P. Bommer, K. Bush, and N. H. Georgopapadakou. 1982. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria. Antimicrob. Agents Chemother. 21:85-92.
26. Urban, C., K. S. Meyer, N. Mariano, J. J. Rahal, R. Flamm, B. A. Rasmussen, and K. Bush. 1994. Identification of TEM-26 β-lactamase responsible for a major outbreak of ceftazidime-tesistant Klebsiella pneumoniae. Antimicrob. Agents Chemother. 38:392-395.
27. Urban, C. Personal communication.
28. Yang, Y., N. Bhachech, and K. Bush. 1995. Biochemical comparison of imipenem, meropenem and biapenem: permeability, binding to penicillin-binding proteins, and stability to hydrolysis by β-lactamases. J. Antimicrob. Chemother. 35:75-84.
29. Young, K., and L. L. Silver. 1991. Leakage of periplasmic enzymes from envA1 strains of Escherichia coli. J. Bacteriol. 173:3609-3614.