Chaperones to the rescue

Scientist

Volumn 16, Issue 22, 2002, Pages 21-23

  Bunk, Steve ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYLBUTYRIC ACID; ALPHA 1 ANTITRYPSIN; AMINO ACID; ANTIBODY; CHAPERONE; ELASTIN; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; MUTANT PROTEIN; OPIATE AGONIST; OPIATE ANTAGONIST; OSMOTIC AGENT; PROTEIN P53; RECEPTOR PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; BRAIN SPONGIOSIS; CATARACT; CELL SURFACE; CHLORIDE CHANNEL; CHRONIC LIVER DISEASE; CLINICAL TRIAL; CREUTZFELDT JAKOB DISEASE; CYSTIC FIBROSIS; DEGENERATIVE DISEASE; DESENSITIZATION; DRUG APPROVAL; DRUG SAFETY; DRUG SCREENING; ENDOPLASMIC RETICULUM; FABRY DISEASE; GENE DELETION; GENE MUTATION; GENE THERAPY; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; HYPERCHOLESTEROLEMIA; HYPERTROPHIC CARDIOMYOPATHY; HYPOGONADOTROPIC HYPOGONADISM; LIPOPHILICITY; LUNG EMPHYSEMA; NEPHROGENIC DIABETES INSIPIDUS; NONHUMAN; NOTE; OSMOTIC SHOCK; PAIN; PARKINSON DISEASE; PROTEIN AGGREGATION; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN TRANSPORT; RETINITIS PIGMENTOSA; SICKLE CELL ANEMIA; THALASSEMIA; TRANSGENIC MOUSE;

EID: 0037064969     PISSN: 08903670     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (6)

1. P.M. Conn et al., "Protein origami: Therapeutic rescue of misfolding gene products," Molecular Interventions, 2:308-16, Sept. 1, 2002.
2. A. Leanos-Miranda et al., "Receptor-misrouting: An unexpectedly prevalent and rescuable etiology in gonadotropin-releasing hormone receptor-mediated hypogonadotropic hypogonadism," Journal of Clinical Endocrinology and Metabolism, 87:4825-8, October 2002.
3. C.R. Brown et al., "Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein," Cell Stress Chaperones, 1:117-25, 1996.
4. J.-P. Morello et al., "Pharmacological chaperones rescue cell-surface expression and function of misfolded VA vasopressin receptor mutants," Journal of Clinical Investigation, 105:887-95, 2000.
5. J.A. Burrows et al., "Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency," Proceedings of the National Academy of Sciences, 97:1796-801, 2000.
6. U.E. Petaja-Repo et al., "Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor mutations," EMBO Journal, 21:1628-37, 2002.