Biological activity of the tryprostatins and their diastereomers on human carcinoma cell lines

Journal of Medicinal Chemistry

Volumn 45, Issue 8, 2002, Pages 1559-1562

  Zhao, Shuo ^a   Smith, Kirsten S ^b   Deveau, Amy Morin ^b   Dieckhaus, Christine M ^b   Johnson, Michael A ^b   Macdonald, Timothy L ^b   Cook, James M ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; TRYPROSTATIN; TRYPROSTATIN A; TRYPROSTATIN B; TRYPTOPHAN; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CELL GROWTH; CYTOTOXICITY; DIASTEREOISOMER; DRUG ACTIVITY; DRUG POTENCY; GROWTH INHIBITION; HUMAN; HUMAN CELL; STEREOCHEMISTRY; STEREOISOMERISM;

ANTINEOPLASTIC AGENTS; BIOPOLYMERS; CELL DIVISION; DNA; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLE ALKALOIDS; PIPERAZINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0037061593     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0155953     Document Type: Article

References (21)

1. Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus Fumigatus
2. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus Fumigatus II. Physico-chemical properties and structures
3. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus Fumigatus I. Taxonomy, fermentation, isolation and biological properties
4. Total synthesis of tryprostatin B: Generation of a nucleophilic prenylating species from a prenylstannane
5. Enantiospecific total synthesis of tryprostatin A
6. Enantiospecific synthesis of optically active 6-methoxytryptophan derivatives and total synthesis of tryprostatin A
7. Total synthesis of tryprostatin A and B as well as their enantiomers
8. Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues
9. Solid-phase synthesis of fumitremorgin, verruculogen and tryprostatin analogues based on a cyclization/cleavage strategy
10. Studies in the Azacope reaction: A formal highly enantioselective synthesis of tryprostatin A
11. Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine
12. Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent
13. Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse
14. 1H NMR spectroscopy: Effect of size of the heterocyclic ring system
15. Regiospecific bromination of 3-methylindoles with NBS and its application to the concise synthesis of optically active unusual tryptophans present in marine cyclic peptides
16. Rapid continuous peptide synthesis via FMOC amino acid chloride coupling and 4-(aminomethyl)piperidine deblocking
17. A consensus sequence for cleavage by vertebrate DNA topoisomerase II
18. Single-strand DNA cleavages by eukaryotic topoisomerase II
19. Tryprostatin A, a specifc and novel inhibitor of microtubule assembly