Changes in MAP2 and tyrosinated α-tubulin expression in cochlear inner hair cells after amikacin treatment in the rat

Journal of Comparative Neurology

Volumn 451, Issue 1, 2002, Pages 70-78

  Ladrech, Sabine ^a   Lenoir, Marc ^a  

^a INSERM   (France)

Author keywords

Auditory sensory cells; Cell survival; Cytoskeleton; Ototoxicity

Indexed keywords

ALPHA TUBULIN; AMIKACIN; ANTIBODY; MICROTUBULE ASSOCIATED PROTEIN 2; TYROSINE;

ACOUSTIC NERVE FIBER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY LABELING; ARTICLE; CELL DEGENERATION; CELL LABELING; CELL SURVIVAL; COCHLEA; CONTROLLED STUDY; HAIR CELL; IMMUNOCYTOCHEMISTRY; MOLECULAR WEIGHT; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STEREOCILIUM;

AMIKACIN; ANIMALS; ANTI-BACTERIAL AGENTS; CELL SURVIVAL; CYTOSKELETON; FLUORESCENT DYES; HAIR CELLS, INNER; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, ANIMAL; RATS; TUBULIN; TYROSINE;

EID: 0037047998     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.10334     Document Type: Article

References (48)

1. Microtubule-associated proteins in adult human sensory organs
2. Degeneration of cochlear neurons after amikacin intoxication in the rat
3. An immunocytochemical and biochemical study of the microtubule-associated protein MAP2 during post lesion dendritic remodeling in the central nervous system of adult rats
4. Transforming growth factor-α-induced cellular changes in organotypic cultures of juvenile, amikacin-treated rat organ of Corti
5. Calbindin (CaBP 28 kDa) appearance and distribution during development of the mouse inner ear
6. Ultrastructural studies of stereocilia in noise-exposed rabbits
7. Ganglioside-enhanced neurite growth: Evidence for a selective induction of high-molecular-weight MAP-2
8. Regulation of microtubule-associated protein 2 (MAP2) expression by nerve growth factor in PC12 cells
9. Actin filaments in sensory hairs of inner ear receptor cells
10. Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment
11. The α tubulin of growth cones is predominantly in the tyrosinated form
12. Structural abnormalities in inner hair cells following kanamycin-induced outer hair cell loss
13. Developmental differentiation of MAP2 expression in the central versus the peripheral and efferent projections of the inner ear
14. Condition of the inner hair cells after aminoglycoside intoxication
15. The role of microtubule associated protein 2: MAP2 in neuronal growth, plasticity and regeneration
16. Rapid regulation of cytoskeletal proteins and their mRNAs following afferent deprivation in the avian cochlear nucleus
17. The arrangements of F-actin, tubulin and fodrin in the organ of Corti of the horseshoe bat (Rhinolophus rouxi) and the gerbil (Meriones unguiculatus)
18. Microtubule-associated proteins MAP2c is involved in the repair of synapses after AMPA induced excitotoxicity in mammalian cochlea
19. Cytoskeletal changes in surviving inner hair cells in the amikacin damaged rat cochlea
20. Morphological and molecular changes in the inner hair cell region of the cochlea after amikacin treatment
21. Organization of cell junctions and cytoskeleton in the reticular lamina in normal and ototoxically damaged organ of Corti
22. Tyrosination state of α tubulin in regenerating peripheral nerve
23. Histopathological differences between temporary and permanent threshold shift
24. Cytoskeletal and calcium-binding proteins in the mammalian organ of Corti: Cell type-specific proteins displaying longitudinal and radial gradients
25. Embryonic MAP2 lacks the cross-linking sidearm sequences and dendritic targeting signal of adult MAP2
26. Spatiotemporal development of cochlear innervation and hair cell differentiation in the rat
27. The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea
28. Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss
29. Age-related changes in microtubules in the guinea pig organ of Corti. Tubulin isoform shifts with increasing age suggest changes in micromechanical properties of the sensory epithelium
30. Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function
31. Diverse distribution and function of fibrous microtubule-associated proteins in the nervous system
32. Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments
33. Immunoelectron microscopy and immunofluorescent labelling of cytoskeletal and muscle-like contractile proteins in inner ear sensory hair cells
34. Actin-binding and microtubule-associated proteins in the organ of Corti
35. Post-translational modifications of tubulin suggest that dynamic microtubules are present in sensory cells and stable microtubules are present in supporting cells of the mammalian cochlea
36. Post-traumatic survival and recovery of the auditory sensory cells in culture
37. Primary structural changes in the organ of Corti after acoustic overstimulation
38. Factors controlling hair-cell regeneration/repair in the inner ear
39. The changing microtubule arrangements in developing hair cells of the chick cochlea
40. The roles of microtubule-associated proteins in brain morphogenesis: A review
41. Microtubule-associated proteins characteristic of embryonic brain are found in the adult mammalian retina
42. Differential localization of the high-and low-molecular weight variants of MAP2 in the developing retina
43. Amikacin intoxication induces apoptosis and cell proliferation in rat organ of Corti
44. The adult rat olfactory system expresses microtubule-associated proteins found in the developing brain
45. Differential turnover of tyrosinated an detyrosinated microtubules
46. Reorganization of the microtubular cytoskeleton by embryonic microtubule-associated protein 2 (MAP2c)
47. Cytoskeletal and muscle-like elements in cochlear hair cells
48. Immunocytochemical and morphological evidence for intracellular self repair as an important contributor to mammalian hair cell recovery