Novel benzimidazole derivatives selectively inhibit endothelial cell growth and suppress angiogenesis in vitro and in vivo

Cancer Letters

Volumn 183, Issue 1, 2002, Pages 53-60

  Hori, Akira ^a   Imaeda, Yasuhiro ^a   Kubo, Keiji ^a   Kusaka, Masami ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Angiogenesis; Benzimidazole; Endothelial cells; Vascular endothelial growth factor

Indexed keywords

1,4 AMINO N [2 [4 [(4 AMINOBENZOYL)AMINO]PHENYL] 1H BENZIMIDAZOL 5 YL]BENZAMIDE; ANGIOGENESIS INHIBITOR; BASIC FIBROBLAST GROWTH FACTOR; BENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL TISSUE; AORTA; ARTICLE; BODY WEIGHT; CELL GROWTH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; ENDOTHELIUM CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; RAT; WEIGHT REDUCTION;

ANIMALS; BENZIMIDAZOLES; CELL DIVISION; CELL LINE; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; HUMANS; KINETICS; LYMPHOKINES; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; ORGAN CULTURE TECHNIQUES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VEINS; WEIGHT GAIN;

EID: 0037044112     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00110-6     Document Type: Article

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