Synthesis of triazole-tethered pyrrolidine libraries: Novel ECE inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 13, 2002, Pages 1727-1730

  Kitas, Eric A ^a   Löffler, Bernd Michael ^a   Daetwyler, Stefan ^a   Dehmlow, Henrietta ^a   Aebi, Johannes D ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME INHIBITOR; METALLOPROTEINASE INHIBITOR; PEPTIDE; PYRROLIDINE DERIVATIVE; TRIAZOLE DERIVATIVE; ZINC ION; ASPARTIC PROTEINASE; ENDOTHELIN-CONVERTING ENZYME 1; METALLOPROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; SOLID; CHEMISTRY; DRUG ANTAGONISM; HUMAN; IC 50; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ASPARTIC ENDOPEPTIDASES; HUMAN; INHIBITORY CONCENTRATION 50; METALLOENDOPEPTIDASES; PROTEASE INHIBITORS; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; HUMANS;

EID: 0037042764     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00254-8     Document Type: Article

References (15)