Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 17, 2000, Pages 2037-2039

  Fink, Cynthia A ^a   Moskal, Michael ^a   Firooznia, Fariborz ^a   Hoyer, Denton ^a   Symonsbergen, David ^a   Wei, Dongchu ^a   Qiao, Ying ^a   Savage, Paula ^a   Beil, Michael E ^a   Trapani, Angelo J ^a   Jeng, Arco Y ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CGS 30084; ENDOTHELIN CONVERTING ENZYME INHIBITOR; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG DESIGN; DRUG ISOLATION; DRUG POTENCY; DRUG SYNTHESIS; ENDOTHELIUM CELL; PROTEIN PROCESSING; SWINE;

ANIMALS; ASPARTIC ENDOPEPTIDASES; DRUG DESIGN; HUMANS; METALLOENDOPEPTIDASES; PROTEASE INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

SUS SCROFA;

EID: 0034605127     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00403-0     Document Type: Article

References (11)