Understanding the basis of CD4+ T-cell depletion in macaques infected by a simian-human immunodeficiency virus

Vaccine

Volumn 20, Issue 15, 2002, Pages 1934-1937

  Etemad Moghadam, Bijan ^a   Rhone, Daniela ^a   Steenbeke, Tavis ^a   Sun, Ying ^a   Manola, Judith ^a   Gelman, Rebecca ^a   Fanton, John W ^c   Racz, Paul ^d   Tenner Racz, Klara ^d   Axthelm, Michael K ^c   Letvin, Norman L ^a   Sodroski, Joseph ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

CD4+ T cell depletion; Membrane fusion; Simian human immunodeficiency virus

Indexed keywords

ENVELOPE PROTEIN; GLYCOPROTEIN;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; MACACA; MEMBRANE FUSION; NONHUMAN; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; VIREMIA; VIRUS REPLICATION;

AMINO ACID SUBSTITUTION; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOPATHOGENIC EFFECT, VIRAL; GENES, ENV; HIV ENVELOPE PROTEIN GP120; HIV-1; MACACA MULATTA; MEMBRANE FUSION; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 0037029938     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00072-5     Document Type: Article

References (9)

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3. A chimeric simian-human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys
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5. + T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques
6. Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1
7. + positive T-cells
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9. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody