Continuous annular chromatography: General characterization and application for the isolation of recombinant protein drugs

Biotechnology and Bioengineering

Volumn 80, Issue 5, 2002, Pages 559-568

  Vogel, Jens H ^a   Nguyen, Huong ^a   Pritschet, Markus ^b   Van Wegen, Richard ^b   Konstantinov, Konstantin ^a  

^a BAYER CORPORATION   (United States)

^b Prior Separation Technology   (Austria)

Author keywords

Continuous bioprocessing; Direct capture; Factor VIII; Ion exchange chromatography; Peak wobbling; Process integration

Indexed keywords

AUTOCLAVES; CELL CULTURE; CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; FERMENTATION; PROTEINS;

ANNULAR CHROMATOGRAPHY;

BIOTECHNOLOGY;

RECOMBINANT PROTEIN; THROMBOPLASTIN;

ARTICLE; CHROMATOGRAPHY; FERMENTATION; ION EXCHANGE CHROMATOGRAPHY; MONITORING; OSCILLATION; PROTEIN ISOLATION; SEPARATION TECHNIQUE; TECHNIQUE; TECHNOLOGY; CELL CULTURE; COMPARATIVE STUDY; CULTURE MEDIUM; EVALUATION; FEASIBILITY STUDY; GENETICS; INSTRUMENTATION; ISOLATION AND PURIFICATION; METHODOLOGY; MICROBIOLOGY; PILOT STUDY; QUALITY CONTROL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

CELLS, CULTURED; CHROMATOGRAPHY; CULTURE MEDIA, SERUM-FREE; FEASIBILITY STUDIES; INDUSTRIAL MICROBIOLOGY; PILOT PROJECTS; QUALITY CONTROL; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; THROMBOPLASTIN;

EID: 0037027815     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10411     Document Type: Article

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