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To the best of our knowledge, this is the first example of palladium-catalyzed intramolecular annulation involving a halide, a carbon-carbon triple bond, and a nucleophile in the same molecule. For palladium-catalyzed intramolecular benzoannulations, see: (a) Kawasaki, T.; Saito, S.; Yamamoto, Y. J. Org. Chem. 2002, 67, 2653. (b) Weibel, D.; Gevorgyan, V.; Yamamoto, Y. J. Org. Chem. 1998, 63, 1217. (c) Saito, S.; Tsuboya, N.; Yamamoto, Y. J. Org. Chem. 1997, 62, 5042. For other palladium-catalyzed intramolecular annulations, see: (d) Hu, Y.; Yang, Z. Org. Lett. 2001, 3, 1387. (e) Piers, E.; Marais, P. C. J. Org. Chem. 1990, 55, 3454.
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To the best of our knowledge, this is the first example of palladium-catalyzed intramolecular annulation involving a halide, a carbon-carbon triple bond, and a nucleophile in the same molecule. For palladium-catalyzed intramolecular benzoannulations, see: (a) Kawasaki, T.; Saito, S.; Yamamoto, Y. J. Org. Chem. 2002, 67, 2653. (b) Weibel, D.; Gevorgyan, V.; Yamamoto, Y. J. Org. Chem. 1998, 63, 1217. (c) Saito, S.; Tsuboya, N.; Yamamoto, Y. J. Org. Chem. 1997, 62, 5042. For other palladium-catalyzed intramolecular annulations, see: (d) Hu, Y.; Yang, Z. Org. Lett. 2001, 3, 1387. (e) Piers, E.; Marais, P. C. J. Org. Chem. 1990, 55, 3454.
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