Removal of the fermentation by-product succinyl L-tyrosine from the β-lactamase inhibitor clavulanic acid using a molecularly imprinted polymer

Biotechnology and Bioengineering

Volumn 79, Issue 1, 2002, Pages 23-28

  Yu, Yihua ^a   Ye, Lei ^a   De Biasi, Vern ^b   Mosbach, Klaus ^a  

^a LUND UNIVERSITY   (Sweden)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Clavulanic acid; Molecularly imprinted polymer; Purification; Succinyl L tyrosine

Indexed keywords

ANTIBIOTICS; BYPRODUCTS; FERMENTATION; IMPURITIES; MONOMERS; PURIFICATION;

MOLECULAR IMPRINTING TECHNIQUE;

ENZYME INHIBITION;

ADSORBENT; BENZENE; BETA LACTAMASE INHIBITOR; CLAVULANIC ACID; METHACRYLIC ACID; POLYMER; TRIMETHYLAMMONIUM SALT DERIVATIVE; TYROSINE DERIVATIVE; VINYL DERIVATIVE;

ADSORPTION; ARTICLE; BINDING AFFINITY; DRUG IMPURITY; DRUG PURIFICATION; DRUG STRUCTURE; FERMENTATION; MOLECULAR IMPRINTING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ADSORPTION; BETA-LACTAMASES; CHEMICAL FRACTIONATION; CLAVULANIC ACID; FERMENTATION; POLYMETHYL METHACRYLATE; STREPTOMYCES; SURFACE PROPERTIES; TYROSINE;

EID: 0037025205     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10271     Document Type: Article

References (24)

1. Molecularly imprinted polymers for bioanalysis: Chromatography, binding assays and biomimetic sensors
2. Chemistry and biosynthesis of clavulanic acid and other clavams
3. New configurations and applications of molecularly imprinted polymers
4. Direct enantioseparation of β-adrenergic blockers using a chiral stationary phase prepared by molecular imprinting
5. Molecularly imprinted polymers and their use in biomimetic sensors
6. Imprinted polymers as tools for the recovery of secondary metabolites produced by fermentation
7. An approach towards surface imprinting using the enzyme ribonuclease A
8. Introducing biomimetic sensors based on molecularly imprinted polymers as recognition elements
9. Clavulanic acid, a β-lactamase inhibitor: Biosynthesis and molecular genetics
10. Imprinted polymers prepared with stoichiometric template-monomer complexes: Efficient binding of ampicillin from aqueous solutions
11. Catalytic silica particles via template-directed molecular imprinting
12. Ion-pair adsorption chromatography for process purposes: Basic equilibrium studies for the recovery of clavulanic acid by using quaternary ammonium salts
13. A specific artificial antibody toward mycophenolic acid prepared by molecular imprinting
14. The emerging technique of molecular imprinting and its future impact on biotechnology
15. Recognition sites incorporating both pyridinyl and carboxy functionalities prepared by molecular imprinting
16. Synthesis and catalysis by molecularly imprinted materials
17. Artificial antibodies to corticosteroids prepared by molecular imprinting
18. Molecular imprinting of synthetic network polymers: The de novo synthesis of macromolecular binding and catalytic sites
19. An enzyme-linked molecularly imprinted sorbent assay
20. Drug assay using antibody mimics made by molecular imprinting
21. Molecular imprinting in cross-linked materials with the aid of molecular templates: A way towards artificial antibodies
22. Molecularly imprinted polymeric adsorbents for by-product removal
23. Use of molecularly imprinted polymers in a biotransformation process
24. Polymers recognizing biomolecules based on a combination of molecular imprinting and proximity scintillation: A new sensor concept