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Kempe M, Glad M, Mosbach K: An approach towards surface imprinting using the enzyme ribonuclease A. J Mol Recognit 1995, 8:35-39. A metal-chelating monomer is polymerized onto methacrylate-derivatized silica particles in the presence of RNase A and metal ions. The adsorbent shows enhanced selectivity in the separation of RNase A and lysozyme.
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Glad M, Reinholdson P, Mosbach K: Molecularly imprinted composite polymers based on trimethylolpropane trimethacrylate (TRIM) particle for efficient enantiomeric separations. Reactive Polymers 1995, 25:47-54.
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Andersson LI, O'Shanessy DJ, Mosbach K: Molecular recognition in synthetic polymers: preparation of chiral stationary phases by molecular imprinting of amino acid amides. J Chromatogr 1990, 513:167-179.
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Ramström O, Nicholls IA, Mosbach K: Synthetic peptide receptor mimics: highly stereoselective recognition in non-covalent molecularly imprinted polymers. Tetrahedron Asymm 1994, 5:649-656. A molecularly imprinted polymer prepared against N-acetyl-L-phenylalanine-L-tryptophan-O-methyl ester is evaluated as a chiral HPLC stationary phase. Marked regioselectivity, enantioselectivity and diasteroselectivity are demonstrated, with enantiomer separation factors up to 17.8.
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Thin layer chromatography based on the molecular imprinting technique
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Kriz D, Berggen-Kriz C, Andersson LI, Mosbach K: Thin layer chromatography based on the molecular imprinting technique. Anal Chem 1994, 66:2636-2639. L-phenylalanine anilide imprinted polymer particles are used as the coating for thin-layer chromatography plates. Efficient enantioseparation is observed, with better retention of L-phenylalanine anilide than its enantiomer, whereas no separation is observed on a plate with non-imprinted polymer.
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Vlatakis, G.1
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24
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0029063139
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Mimics of the binding sites of opioid receptors obtained by molecular imprinting of enkephalin and morphine
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Andersson LI, Müller R, Vlatakis G, Mosbach K: Mimics of the binding sites of opioid receptors obtained by molecular imprinting of enkephalin and morphine. Proc Natl Acad Sci USA 1995, 92:4788-4792. The recognition properties of morphine and enkephalin imprinted polymers are evaluated by radioligand binding analysis. The polymers exhibit high binding affinity and high selectivity in aqueous buffers. Applications are suggested for imprinted polymers in drug development.
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Proc Natl Acad Sci USA
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Andersson, L.I.1
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Application of molecular imprinting to the development of aqueous buffer and organic solvent based radioligand binding assays for S-propanolol
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Andersson LI: Application of molecular imprinting to the development of aqueous buffer and organic solvent based radioligand binding assays for S-propanolol. Anal Chem 1996, in press. In this report, the conditions used for radioligand binding assays are optimized. Compared with previous studies using this kind of assay, the limit of detection is improved 100-fold and the amount of polymer used is reduced 100-fold.
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Anal Chem
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Andersson, L.I.1
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0027611808
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Some studies of molecularly-imprinted polymer membrane in combination with field-effect devices
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Hedborg, E.1
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Introducing biomimetic sensors based on molecularly imprinted polymers as recognition elements
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Kriz D, Ramström O, Svensson NA, Mosbach K: Introducing biomimetic sensors based on molecularly imprinted polymers as recognition elements. Anal Chem 1995, 34:2142-2144. Fibre-optic detection of an amino acid derivatized with a fluorescent labelling group (dansyl-L-phenylalanine) is demonstrated. The recognition element is an imprinted polymer, and the device exhibits selectivity for the print molecule compared with the enantiomer. Although applicable only to fluorescent analytes, this relatively simple system might be extended to measurements in real samples because it is potentially less prone to interference from other species in solution than other imprinting-based sensing devices reported thus far.
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Kriz, D.1
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Competitive amperometric morphine sensor based on an agarose immobilised molecularly imprinted polymer
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Preparation and characterization of composite polymers exhibiting both selective molecular recognition and electrical conductivity
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Studies on guest selective molecular recognition on an octadecyl silylated silicon surface using ellipsometry
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Piletski SA, Parhometz YP, Lavryck NV, Panasyuk TL, El'skaya AV: Sensors for low-weight organic molecules based on molecular imprinting technique. Sensors Actuators B 1994, 18-19:629-631.
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Piletski, S.A.1
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Sellergen B: Imprinted dispersion polymers: a new class of easily accessible affinity stationary phases. J Chromatogr 1994, 673:133-141. Non-stabilizing dispersion polymerization, in combination with molecular imprinting, is used to prepare agglomerates of globular micron-sized particles exhibiting recognition properties. Addition of water to the dispersion medium allows imprinting of the poorly soluble template pentamidine.
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Sellergen, B.1
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0001353276
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Racemic resolution of free sugars with macroporous polymers prepared by molecular imprinting. Selectivity dependence on the arrangement of functional groups versus spatial requirements
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Wulff G, Schauhoff S: Racemic resolution of free sugars with macroporous polymers prepared by molecular imprinting. Selectivity dependence on the arrangement of functional groups versus spatial requirements. J Org Chem 1991, 56:395-400.
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Sugar binding polymers showing high anomeric and epimeric discrimination obtained by noncovalent molecular imprinting
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Mayes AG, Andersson LI, Mosbach K: Sugar binding polymers showing high anomeric and epimeric discrimination obtained by noncovalent molecular imprinting. Anal Biochem 1994, 222:483-488. Non-covalent imprinting is applied to the imprinting of sugar derivatives for the first time. The polymers are characterized as HPLC stationary phases and in radioligand displacement asays.
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Anal Biochem
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Mayes, A.G.1
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Molecular imprinting of acetylated carbohydrate derivatives into methacrylic polymers
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Nilsson KGI, Sakaguchi K, Gemeiner P, Mosbach K: Molecular imprinting of acetylated carbohydrate derivatives into methacrylic polymers. J Chromatogr 1995, 707:199-203.
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J Chromatogr
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Nilsson, K.G.I.1
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42
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0026331366
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Direct enantioseparation of β-adrenergic blockers using a chiral stationary phase prepared by molecular imprinting
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Fischer L, Müller R, Ekberg B, Mosbach K: Direct enantioseparation of β-adrenergic blockers using a chiral stationary phase prepared by molecular imprinting. J Am Chem Soc 1991, 113:9358-9360.
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Fischer, L.1
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0028196748
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Direct resolution of Naproxen on a non-covalently molecularly imprinted chiral stationary phase
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Kempe M, Mosbach K: Direct resolution of Naproxen on a non-covalently molecularly imprinted chiral stationary phase. J Chromatogr 1994, 664:276-279. 4-Vinylpyridine and ethylene glycol dimethacrylate are co-polymerized in the presence of S-Naproxen. The polymer is used as a stationary phase in HPLC. Racemic Naproxen is efficiently resolved on the polymer and separated from the structurally related ibuprofen and ketoprofen.
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J Chromatogr
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Polymer complements to nucleotide bases. Selective binding of adenine derivatives to imprinted polymers
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Shea KJ, Spivak DA, Sellergren B: Polymer complements to nucleotide bases. Selective binding of adenine derivatives to imprinted polymers. J Am Chem Soc 1993, 115:3368-3360.
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Shea, K.J.1
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A new method for the introduction of recognition site functionality into polymers prepared by molecular imprinting, synthesis and characterisation of polymeric receptors for cholesterol
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Whitcombe MJ, Rodriguez ME, Villar P, Vulfson EN: A new method for the introduction of recognition site functionality into polymers prepared by molecular imprinting, synthesis and characterisation of polymeric receptors for cholesterol. J Am Chem Soc 1995, 117:7105-7111. The imprinting of cholesterol, a compound with a single hydroxyl group, is performed by a new methodology relying on the use of a 4-vinylphenyl carbonate ester. The latter functions as a covalently bound template monomer, which is efficiently cleaved hydrolytically, with the loss of carbon dioxide, resulting in a non-covalent recognition site that interacts with the print molecule through hydrogen bonding.
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Influence of protein on polysiloxane polymer formation: Evidence for induction of complementary protein-polymer interactions
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Venton, D.L.1
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