Synthesis and evaluation of 5-HT2A and 5-HT2C receptor binding affinities of novel pyrimidine derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 21, 2002, Pages 3097-3099

  Bózsing, Dániel ^a   Simonek, Ildikó ^a   Simig, Gyula ^a   Jakóczi, Iván ^a   Gacsályi, István ^a   Lévay, György ^a   Tihanyi, Károly ^a   Schmidt, Éva ^a  

^a EGIS PHARMACEUTICALS LTD   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

(2 CHLOROBENZYL)PIPERAZINE; (2 TRIFLUOROMETHYLBENZYL)PIPERAZINE; (3 TRIFLUOROMETHYLBENZYL)PIPERAZINE; 2 (PIPERAZINYLETHYLTHIO)PYRIMIDINE; 2 MERCAPTOPYRIMIDINE; 2,4 DIAMINOPYRIMIDINE DERIVATIVE; ANXIOLYTIC AGENT; N BENZYL N'(2 CHLOROETHYL)PIPERAZINE; NEUROLEPTIC AGENT; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE; PYRIMIDINE SYNTHESIS; RECEPTOR AFFINITY;

LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PYRIMIDINES; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037020750     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00660-1     Document Type: Article

References (13)

1. Blackburn, T.P. In Advances in Neuropharmacology; Rose, F. C., ed.; Smith-Gordon and Nishimura. New York, 1993; p 51.
2. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P.A. Pharmacol. Rev. 46:1994;157.
3. Kennett G.A. Curr. Opin. Invest. Drugs. 2:1993;317.
4. Wainscott D.B., Cohen M.L., Schenck K.W., Adia J.E., Nissen J.S., Baez M., Kursar J.D., Lucaites V.L., Nelson D.L. Mol. Pharmacol. 43:1993;4l9.
5. Dudley M., Ogden A., Carr A., Nieduzak T., Kehne J. Soc. Neurosci. 19:1990;427.
6. Forbes I.T., Ham P., Booth D.H., Martin R.T., Thompson M., Baxter G.S., Blackburn T.P., Glen A., Kennett G.A., Wood M.D. J. Med. Chem. 38:1995;2524.
7. Weinhardt K.K., Bonhaus D.W., De Souza A. Bioorg. Med. Chem. Lett. 6:1996;2687.
8. Jakóczi, I. WO 9,716,429, 1997. Chem. Abstr. 1997, 127, 34248t.
9. Navio J.L.G., Lorente A., Soto J.L. Heterocycles. 19:1982;305.
10. Ross S.D., Bruno J.J., Petersen R.C. J. Am. Chem. Soc. 85:1963;3999.
11. -1.
12. Leysen J.E., Niemegeers C.J.E., Van Nueten J.M., Laduron P.M. Mol. Pharmacol. 21:1981;301.
13. Pazos A., Hoyer D., Palacoious J.M. Eur. J. Pharmacol. 106:1985;539.