Hypertension-linked decrease in the expression of brain γ-adducin

Circulation Research

Volumn 91, Issue 7, 2002, Pages 633-639

  Yang, Hong ^a   Francis, Sharon C ^a   Sellers, Kathleen ^a   DeBarros, Mia ^a   Sun, Chengwen ^a   Sumners, Colin ^a   Ferrario, Carlos M ^c   Katovich, Michael J ^b   Muro, Andrés F ^d   Raizada, Mohan K ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

adducin; Gene profiling; Hypertension; Hypothalamus brainstem; Neurons

Indexed keywords

ADDUCIN; ALPHA ADDUCIN; BETA ADDUCIN; GAMMA ADDUCIN; LOSARTAN; NEUROTRANSMITTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; BRAIN STEM; CONTROLLED STUDY; DNA POLYMORPHISM; GENE EXPRESSION; HYPERTENSION; HYPOTHALAMUS; NERVE CELL CULTURE; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; REGULATORY MECHANISM; SPONTANEOUSLY HYPERTENSIVE RAT;

ACTION POTENTIALS; ANIMALS; BRAIN; BRAIN STEM; CALMODULIN-BINDING PROTEINS; CELLS, CULTURED; DOWN-REGULATION; GENE EXPRESSION PROFILING; HYPERTENSION; HYPOTHALAMUS; NEURONS; PROTEIN SUBUNITS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0037019952     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000036749.73316.73     Document Type: Article

References (24)

1. Izzo JL Jr, Taylor AA. The sympathetic nervous system and baroreflexes in hypertension and hypotension. Curr Hypertens Rep. 1999;1:254-263.
2. Wyss JM, Carlson SH. The role of the nervous system in hypertension. Curr Hypertens Rep. 2001;3:255-262.
3. Mancia G, Grassi G, Parati G, Zanchetti A. The sympathetic nervous system in human hypertension. Rev Port Cardiol. 2000;19(suppl 2):II15-II19.
4. Francis SC, Yang H, Veerasingham S, Sumners C, Raizada MK. Differential gene expression profiling in SHR verses WKY brains. Hypertension. 2001;38:496. Abstract.
5. Matsuoka Y, Li X, Bennett V. Adducin, structure, function and regulation. Cell Mol Life Sci. 2000;57:884-895.
6. Manunta P, Barlassina C, Bianchi G. Adducin in essential hypertension. FEBS Lett. 1998;430:41-44.
7. Marro ML, Scremin OU, Jordan MC, Huynh L, Porto F, Roos KP, Gajovic S, Baralle FE, Muro AF. Hypertension in β-adducin-deficient mice. Hypertension. 2000;36:449-453.
8. Iwai N, Tamaki S, Nakamura Y, Kinoshita M. Polymorphism of α-adducin and hypertension. Lancet. 1997;350:369. Letter.
9. He X, Zhu DL, Chu SL, Jin L, Xiong MM, Wang GL, Zhang WZ, Zhou HF, Mao SY, Zhan YM, Zhuang QN, Liu XM, Zhao Y, Huang W. α-Adducin gene and essential hypertension in China. Clin Exp Hypertens. 2001;23:579-589.
10. Tripodi G, Valtorta F, Torielli L, Chieregatti E, Salardi S, Trusolino L, Menegon A, Ferrari P, Marchisio PC, Bianchi G. Hypertension-associated point mutations in the adducin α and β subunits affect actin cytoskeleton and ion transport. J Clin Invest. 1996;97:2815-2822.
11. +-ATPase: relation to genetic hypertension. Am J Physiol. 1999;277:H1338-H1349.
12. Raizada MK, Lu D, Sumners C. AT1 receptors and angiotensin actions in the brain and neuronal cultures of normotensive and hypertensive rats. Adv Exp Med Biol. 1995;377:331-348.
13. Lu D, Yang H, Raizada MK. Regulation of angiotensin II-induced neuromodulation by MARCKS in brain neurons. J Cell Biol. 1998;142:217-227.
14. Muro AF, Marro ML, Gajovic S, Porro F, Luzzatto L, Baralle FE. Mild spherocytic hereditary elliptocytosis and altered levels of α- and γ-adducins in β-adducin-deficient mice. Blood. 2000;95:3978-3985.
15. Zhu M, Sumners C, Gelband CH, Posner P. Chronotropic effect of angiotensin II via type 2 receptors in rat brain neurons. J Neurophysiol. 2001;85:2177-2183.
16. Gelband CH, Sumners C, Lu D, Raizada MK. Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling. Regul Pept. 1998;73:141-147.
17. Sun C, Sumners C, Raizada MK. Chronotropic action of angiotensin II in neurons via protein kinase C and CaMKII. Hypertension. 2002;39:562-566.
18. +-ATPase as an effector of synaptic transmission. Neurochem Int. 1992;20:19-22.
19. Zagato L, Modica R, Florio M, Torielli L, Bihoreau MT, Bianchi G, Tripodi G. Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats. Hypertension. 2000;36:734-739.
20. Ciechanowicz A, Widecka K, Drozd R, Adler G, Cyrylowski L, Czekalski S. Lack of association between Gly 460 Trp polymorphism of α-adducin gene and salt sensitivity of blood pressure in polish hypertensive kidney blood pressure. Kidney Blood Press Res. 2001;24:201-206.
21. Schork NJ, Chakravarti A, Thiel B, Fornage M, Jacob HJ, Cai R, Rotimi CN, Cooper RS, Weder AB. Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and African Americans. Am J Hypertens. 2000;13:396-698.
22. Matsuoka Y, Li X, Bennett V. Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. J Cell Biol. 1998;142:485-497.
23. Li X, Matsuoka Y, Bennett V. Adducin preferentially recruits spectrin to fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain. J Biol Chem. 1998;273:I9329-I9338.
24. Yang H, Wang X, Sumners C, Raizada MK. Obligatory role of protein kinase C and MARCKS in vesicular trafficking in living neurons. Hypertension. 2002;39:567-572.