Choline in the aging brain

Brain Research

Volumn 951, Issue 2, 2002, Pages 158-165

  Katz Brull, Rachel ^a,b   Koudinov, Alexei R ^a   Degani, Hadassa ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Choline phospholipid synthesis; Cortex; Diffusion; High affinity and low affinity choline transport; Hippocampus; Proton magnetic resonance spectroscopy

Indexed keywords

CHOLINE; CREATINE; N ACETYLASPARTIC ACID;

AGED; AGING; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN SLICE; CONTROLLED STUDY; DIFFUSION; HIPPOCAMPUS; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; KINETICS; LIPOGENESIS; MALE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

AGING; ALGORITHMS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BRAIN CHEMISTRY; CEREBRAL CORTEX; CHOLINE; HIPPOCAMPUS; KINETICS; LIPID METABOLISM; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, WISTAR;

EID: 0037019902     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03155-4     Document Type: Article

References (33)

1. Agut J., Font E., Sacristan A., Ortiz J.A. Dissimilar effects in acute toxicity studies of CDP-choline and choline. Arzneim. Forsch. 33:1983;1016-1018.
2. Allen D.D., Smith Q.R. Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique. J. Neurochem. 76:2001;1032-1041.
3. Antonelli T., Beani L., Bianchi C., Pedata F., Pepeu G. Changes in synaptosomal high affinity choline uptake following electrical stimulation of guinea-pig cortical slices: effect of atropine and physostigmine. Br. J. Pharmacol. 74:1981;525-531.
4. Apparsundaram S., Ferguson S.M., George A.L.J., Blakely R.D. Molecular cloning of a human, hemicholinium-3-sensitive choline transporter. Biochem. Biophys. Res. Commun. 276:2000;862-867.
5. Blusztajn J.K. Choline, a vital amine. Science. 281:1998;794-795.
6. L. Bolinger, R.E. Lenkinski, Localization in clinical NMR spectroscopy, in: L.J. Berliner, J. Reuben (Eds.), Biological Magnetic Resonance, Vol. 11: In Vivo Spectroscopy, 1992, pp. 1-53.
7. Brenner R.E., Munro P.M., Williams S.C., Bell J.D., Barker G.J., Hawkins C.P., Landon D.N., McDonald W.I. The proton NMR spectrum in acute EAE: the significance of the change in the Cho:Cr ratio. Magn. Reson. Med. 29:1993;737-745.
8. Cecil K.M., Lenkinski R.E. Proton MR spectroscopy in inflammatory and infectious brain disorders. Neuroimaging Clin. N. Am. 8:1998;863-880.
9. Cermak J.M., Holler T., Jackson D.A., Blusztajn J.K. Prenatal availability of choline modifies development of the hippocampal cholinergic system. FASEB J. 12:1998;349-357.
10. Cohen B.M., Renshaw P.F., Stoll A.L., Wurtman R.J., Yurgelun-Todd D., Babb S.M. Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study. J. Am. Med. Assoc. 274:1995;902-907.
11. Cornell R.B., Northwood I.C. Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization. Trends Biochem. Sci. 25:2000;441-447.
12. Cornford E.M., Braun L.D., Oldendorf W.H. Carrier mediated blood-brain barrier transport of choline and certain choline analogs. J. Neurochem. 30:1978;299-308.
13. Dechent P., Pouwels P.J., Frahm J. Neither short-term nor long-term administration of oral choline alters metabolite concentrations in human brain. Biol. Psychiatry. 46:1999;406-411.
14. Glonek T., Kopp S.J., Kot E., Pettegrew J.W., Harrison W.H., Cohen M.M. P-31 nuclear magnetic resonance analysis of brain: the perchloric acid extract spectrum. J. Neurochem. 39:1982;1210-1219.
15. Hennig J., Nauerth A., Friedburg H. RARE imaging: a fast imaging method for clinical MR. Magn. Reson. Med. 3:1986;823-833.
16. Katz-Brull R., Margalit R., Degani H. Differential routing of choline in implanted breast cancer and normal organs. Magn. Reson. Med. 46:2001;31-38.
17. Loffelholz K., Klein J., Koppen A. Choline, a precursor of acetylcholine and phospholipids in the brain. Prog. Brain Res. 98:1993;197-200.
18. Massarelli R., Mykita S., Sorrentino G. The supply of choline to glial cells. Astrocytes (Biochem. Physiol. Pharmacol.). 2:1986;155-177.
19. Okuda T., Haga T., Kanai Y., Endou H., Ishihara T., Katsura I. Identification and characterization of the high-affinity choline transporter. Nat. Neurosci. 3:2000;120-125.
20. Pepeu G., Casamenti F., Pepeu I., Scali C. The brain cholinergic system in ageing mammals. J. Reprod. Fertil. Suppl. 46:1993;155-162.
21. Pfefferbaum A., Adalsteinsson E., Spielman D., Sullivan E.V., Lim K.O. In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease. Arch. Gen. Psychiatry. 56:1999;185-192.
22. Pomfret A.A., da Costa K.A., Schurman L.L., Zeisel S.H. Measurement of choline and choline metabolite concentrations using high pressure liquid chromatography and gas chromatography mass spectrometry. Anal. Biochem. 180:1989;85-90.
23. Preul M.C., Caramanos Z., Collins D.L., Villemure J.G., Leblanc R., Olivier A., Pokrupa R., Arnold D.L. Accurate, noninvasive diagnosis of human brain tumors by using proton magnetic resonance spectroscopy. Nat. Med. 2:1996;323-325.
24. Sarter M., Bruno J.P. Age-related changes in rodent cortical acetylcholine and cognition: main effects of age versus age as an intervening variable. Brain Res. Brain Res. Rev. 27:1998;143-156.
25. Schuberth J., Sundwall A. A method for the determination of choline in biological materials. Acta Pharmacol. Toxicol. 29:1971;51.
26. Stein W.D. Kinetics of transport: analyzing, testing and characterizing models using kinetic approach. Methods Enzymol. Biomembr. 171:1989;23-62.
27. Stoppe G., Bruhn H., Pouwels P.J., Hanicke W., Frahm J. Alzheimer disease: absolute quantification of cerebral metabolites in vivo using localized proton magnetic resonance spectroscopy. Alzheimer Dis. Assoc. Disord. 14:2000;112-119.
28. Tan J., Bluml S., Hoang T., Dubowitz D., Mevenkamp G., Ross B. Lack of effect of oral choline supplement on the concentrations of choline metabolites in human brain. Magn. Reson. Med. 39:1998;1005-1010.
29. Tyagi R.K., Azrad A., Degani H., Salomon Y. Simultaneous extraction of cellular lipids and water-soluble metabolites: evaluation by NMR spectroscopy. Magn. Reson. Med. 35:1996;194-200.
30. Wurtman R.J. Choline metabolism as a basis for the selective vulnerability of cholinergic neurons. Trends Neurosci. 15:1992;117-122.
31. Xin Q., Wightman R.M. Transport of choline in rat brain slices. Brain Res. 776:1997;126-132.
32. Yamamura H.I., Snyder S.H. Choline: high-affinity uptake by rat brain synaptosomes. Science. 178:1972;626-628.
33. Zeisel S.H., Costa K.A.D., Franklin P.D., Alexander E.A., Lamont J.T., Sheard N.F., Beiser A. Choline, an essential nutrient for humans. FASEB J. 5:1991;2093-2098.