Hybrid ubiquinone: Novel inhibitor of mitochondrial complex I

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1556, Issue 2-3, 2002, Pages 106-112

  Yabunaka, Hiromi ^a   Kenmochi, Atsushi ^a   Nakatogawa, Yasushi ^a   Sakamoto, Kimitoshi ^a   Miyoshi, Hideto ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Mitochondrial complex I; Structure activity relationship; Ubiquinone

Indexed keywords

BENZOQUINONE DERIVATIVE; ENZYME INHIBITOR; PHENOXYBENZAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UBIQUINONE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HEART MITOCHONDRION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYBRID; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATTLE; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; ELECTRON TRANSPORT COMPLEX III; MITOCHONDRIA, HEART; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; MYOCARDIUM; NADH, NADPH OXIDOREDUCTASES; OXIDATION-REDUCTION; OXIDOREDUCTASES; PESTICIDES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBMITOCHONDRIAL PARTICLES; SUCCINATE DEHYDROGENASE; UBIQUINONE;

BOVINAE;

EID: 0037010846     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2728(02)00341-9     Document Type: Article

References (21)

1. Friedrich T., Van Heek P., Leif H., Ohnishi T., Forche E., Kunze B., Jansen R., Trowitzsch-Kienast W., Höfle G., Reichenbach H., Weiss H. Eur. J. Biochem. 219:1994;691-698.
2. Degli Esposti M. Biochim. Biophys. Acta. 1364:1998;222-235.
3. Miyoshi H. Biochim. Biophys. Acta. 1364:1998;236-244.
4. Kean E.A., Gutman M., Singer T.P. J. Biol. Chem. 246:1971;2346-2353.
5. Majander A., Finel M., Wikström M. J. Biol. Chem. 269:1994;21037-21042.
6. Okun J.G., Lümmen P., Brandt U. J. Biol. Chem. 274:1999;2625-2630.
7. Schuler F., Yano T., Bernardo S.D., Yagi T., Yankovskaya V., Singer T.P., Casida J.E. Proc. Natl. Acad. Sci. U. S. A. 96:1999;4149-4153.
8. Kim H., Xia D., Yu C.A., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J. Proc. Natl. Acad. Sci. U. S. A. 95:1998;8026-8033.
9. Ahlers P.M., Zwicker K., Kerscher S., Brandt U. J. Biol. Chem. 275:2000;23577-23582.
10. Kashani-Poor N., Zwicker K., Kerscher S., Brandt U. J. Biol. Chem. 276:2001;24082-24087.
11. Prieur I., Lunardi J., Dupuis A. Biochim. Biophys. Acta. 1504:2001;173-178.
12. Matsuno-Yagi A., Hatefi Y. J. Biol. Chem. 260:1985;14424-14427.
13. Sakamoto K., Miyoshi H., Ohshima M., Kuwabara K., Kano K., Akagi T., Mogi T., Iwamura H. Biochemistry. 37:1998;15106-15113.
14. Ohshima M., Miyoshi H., Sakamoto K., Takegami K., Iwata J., Kuwabara K., Iwamura H., Yagi T. Biochemistry. 37:1998;6436-6445.
15. Satoh T., Miyoshi H., Sakamoto K., Iwamura H. Biochim. Biophys. Acta. 1273:1996;21-30.
16. Rieske J.S. Methods Enzymol. 10:1967;239-245.
17. Fato R., Estornell E., Bernardo S.D., Pallotti F., Castelli G.P., Lanaz G. Biochemistry. 35:1996;2705-2716.
18. He D.Y., Gu L.Q., Yu L., Yu C.A. Biochemistry. 33:1994;880-884.
19. Croft A.R., Wang Z. Photosynth. Res. 22:1989;69-87.
20. Miyoshi H. J. Bioenerg. Biomembranes. 33:2001;223-231.
21. Perrior T.R. Chem. Ind. (Lond.). 1993;883-887.