Synthesis of 6,8-substituted-5,7-difluoro-3,4-dihydro-1H-quinoxalin-2-ones via reductive cyclisation of 2,4,6-substituted-3,5-difluoronitrobenzenes

Tetrahedron Letters

Volumn 43, Issue 36, 2002, Pages 6435-6437

  Holland, Richard J ^a   Hardcastle, Ian R ^a,b   Jarman, Michael ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; NITROBENZENE DERIVATIVE; QUINOXALINE DERIVATIVE; ZINC;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; REDUCTION; RELIABILITY; SOLID;

EID: 0037009730     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)01363-1     Document Type: Article

References (12)

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11. Excess tin salts were removed from the crude product by washing with 1:1 NaOH (1 M), DCM.
12. 2H), Supelco discovery C18 column (5 cm×4.6 mm). Analysis by UV was recorded at 254 nm. MS was conducted on a Finnigan MAT LCQ in electrospray mode. Purities are based on the peak integral of the crude product peak.