Vomitoxin (deoxynivalenol)-mediated inhibition of nuclear protein binding to NRE-A, an IL-2 promoter negative regulatory element, in EL-4 cells

Toxicology

Volumn 172, Issue 3, 2002, Pages 169-179

  Yang, Gi Hyeok ^a,b,c   Pestka, James J ^a,b,c  

^a Michigan State University   (United States)

^b Michigan State University ^*  (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

EF1; AREB6; Immunotoxicology; Interleukin 2; MEB1; Mycotoxin; Nil 2 a; NRE A; Transcription factor; Trichothecene; ZEB

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; IONOMYCIN; MESSENGER RNA; NUCLEAR PROTEIN; PHORBOL 12 ACETATE 13 MYRISTATE; TRANSCRIPTION FACTOR; VOMITOXIN;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; CELL LYSATE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; BLOTTING, WESTERN; CELL NUCLEUS; CELLS, CULTURED; DNA-BINDING PROTEINS; ELECTROPHORESIS; GENES, REGULATOR; HOMEODOMAIN PROTEINS; INTERLEUKIN-2; MICE; MYCOTOXINS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRICHOTHECENES;

MURINAE;

EID: 0037006924     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00003-3     Document Type: Article

References (46)

1. Cytokines
2. Immunochemical assessment of mycotoxins in 1989 grain foods: Evidence for deoxynivalenol (vomitoxin) contamination
3. Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): Relationship to toxin distribution and protein synthesis inhibition
4. Dietary exposure to the trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer's patch B cells to IgA secreting plasma cells
5. Immunomodulation by fungal toxins
6. Negative regulation of CD4 expression in T cells by the transcriptional repressor ZEB
7. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
8. Persistent dysregulation of IgA production and IgA nephropathy in the B6C3F1 mouse following withdrawal of dietary vomitoxin (deoxynivalenol)
9. Quantitative assessment of mesangial immunoglobulin A (IgA) accumulation, elevated circulating IgA immune complexes, and hematuria during vomitoxin-induced IgA nephropathy
10. Elevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymoma
11. Effects of 8-week exposure of the B6C3F1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone
12. Identification of nuclear factor delta EF1 and its binding site essential for lens-specific activity of the delta 1-crystallin enhancer
13. Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis
14. Cloning of a cDNA encoding a mouse transcriptional repressor displaying striking sequence conservation across vertebrates
15. Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: Implications for B-cell specificity of the immunoglobulin heavy-chain enhancer
16. Reproducibility in the quantification of mRNA levels by RT-PCR-ELISA and RT competitive-PCR-ELISA
17. Impairment of T cell development in deltaEF1 mutant mice
18. Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear fa
19. The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression
20. Embryotoxicity of 4-deoxynivalenol (vomitoxin) in mice
21. Modulation of transcription factor AP-1 activity in murine EL-4 thymoma cells by vomitoxin (deoxynivalenol)
22. Attenuation of p53 expression and Bax down-regulation during phorbol ester mediated inhibition of apoptosis
23. Control of lymphokine expression in T helper 2 cells
24. Vomitoxin-mediated IL-2, IL-4, and IL-5 superinduction in murine CD4+ T cells stimulated with phorbol ester calcium ionophore: Relation to kinetics of proliferation
25. Effects of vomitoxin (deoxynivalenol) on transcription factor NF-kappa B/Rel binding activity in murine EL-4 thymoma and primary CD4+ T cells
26. Dysregulation of IgA production and IgA nephropathy induced by the trichothecene vomitoxin
27. Elevated membrane IgA+ and CD4+ (T helper) populations in murine Peyer's patch and splenic lymphocytes during dietary administration of the trichothecene vomitoxin (deoxynivalenol)
28. Elevated membrane IgA+ and CD4+ (T helper) populations in murine Peyer's patch and splenic lymphocytes during dietary administration of the trichothecene vomitoxin (deoxynivalenol)
29. Inhibition of IL-2 production by Nil-2-a in murine T cells
30. The delta-crystallin enhancer-binding protein delta EF1 is a repressor of E2-box-mediated gene activation
31. Organization of the gene encoding transcriptional repressor deltaEF1 and cross-species conservation of its domains
32. The architecture of the interleukin-2 promoter: A reflection of T lymphocyte activation
33. DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages
34. Worldwide contamination of cereals by the Fusarium mycotoxins nivalenol, deoxynivalenol, and zearalenone, 1. Survey of 19 countries
35. Toxicological features of T-2 toxin and related trichothecenes
36. In vitro effects of vomitoxin (deoxynivalenol) on T-cell interleukin production and IgA secretion
37. Transcription factors positively and negatively regulating the Na, K-ATPase alpha 1 subunit gene
38. Identification of a zinc finger protein that inhibits IL-2 gene expression
39. Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin
40. Apoptosis induction by the satratoxins and other trichothecene mycotoxins: Relationship to ERK, p38 MAPK, and SAPK/JNK activation
41. Down-regulation of the endoplasmic reticulum chaperone GRP78/BiP by vomitoxin (deoxynivalenol)
42. Transcriptional repression of the IL-2 gene in Th cells by ZEB
43. Negative regulation of cytokine gene transcription
44. Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): Dose response and time course
45. Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (deoxynivalenol): Differential toxin-induced hyporesponsiveness and recovery
46. Superinduction of IL-2 gene transcription in the presence of cycloheximide