Enhancement of skin permeation of miconazole by phospholipid and dodecyl 2-(N,N-dimethyl amino)propionate (DDAIP)

International Journal of Pharmaceutics

Volumn 234, Issue 1-2, 2002, Pages 121-128

  Fujii, M ^a   Buyuktimkin S ^b   Buyuktimkin N ^b   Rytting, J H ^b  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

Dodecyl 2 (N,N dimethyl amino)propionate; Enhancer; Miconazole; Phospholipid; Shed snakeskin; Skin permeation

Indexed keywords

DODECYL 2 (N,N DIMETHYLAMINO)PROPIONATE; DRUG VEHICLE; MICONAZOLE; MINERAL OIL; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; UNCLASSIFIED DRUG; WATER;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG TISSUE LEVEL; GEL; HEATING; INTOXICATION; NONHUMAN; PRIORITY JOURNAL; SKIN; SKIN PERMEABILITY; SNAKE;

ALANINE; ANIMALS; ANTIFUNGAL AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GELS; MICONAZOLE; MINERAL OIL; OINTMENT BASES; PHOSPHOLIPIDS; SKIN ABSORPTION; SNAKES; SOLUBILITY; STIMULATION, CHEMICAL; SUSPENSIONS;

EID: 0037006594     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00951-6     Document Type: Article

References (16)

1. In vivo and in vitro skin uptake and permeation studies; critical considerations and factors which affect them
2. Synthesis and enhancing effect of Dodecyl 2-(N,N-dimethylamino)propionate on the transepidermal delivery of indomethacin, clonidine, and hydrocortisone
3. Alkyl N,N-disubstituted-amino acetate
4. Interaction of indomethacin with a new penetration enhancer, dodecyl 2-(N,N-dimethylamino)propionate (DDAIP): Its effect on transdermal delivery
5. Oily gel formed by hydrogenated soybean phospholipids and its properties
6. Effect of storage temperature and phosphatidylcholine content on the properties of oily gel formed by hydrogenated phospholipids
7. Effect of phosphatidylcholine on skin permeation of indomethacin from gel prepared with liquid paraffin and hydrogenated phospholipid
8. Iontophoretic drug delivery
9. Application of an oily gel formed by hydrogenated soybean phospholipids as a percutaneous absorption-type ointment base
10. Physical chemical analysis of percutaneous absorption process from creams and ointments
11. Analysis of data on the medicament release from ointments
12. In vitro release of tranilast from oily gels and penetration of the drug into Yucatan micropig skin
13. Formation and antimycotic effect of cyclodextrin inclusion complexes of econazole and miconazole
14. On the mechanisms of in vitro and in vivo phonophoresis
15. Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations
16. Preparation, characterization, and evaluation of miconazole-cyclodextrin complexes for improved oral and topical delivery