INGN-241: Introgen

Current Opinion in Investigational Drugs

Volumn 3, Issue 12, 2002, Pages 1773-1777

  Gopalkrishnan, Rahul ^a  

^a Department of Pathology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTILEUKEMIC AGENT; ANTINEOPLASTIC AGENT; CYTOKINE; DOCETAXEL; DOXORUBICIN; INGN 241; INTERLEUKIN 24; MEZEREIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; RADIOSENSITIZING AGENT; RECOMBINANT BETA INTERFERON; TAMOXIFEN; TRASTUZUMAB; UNCLASSIFIED DRUG;

ADENOVIRUS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CLINICAL TRIAL; DISEASE SEVERITY; DRUG CONTRAINDICATION; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG FEVER; DRUG HALF LIFE; DRUG ISOLATION; DRUG METABOLISM; DRUG POTENTIATION; DRUG SAFETY; DRUG STABILITY; DRUG SYNTHESIS; DRUG TOLERABILITY; FLU LIKE SYNDROME; GENE; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSCRIPTION; HUMAN; INJECTION PAIN; LICENCE; LUNG NON SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; MULTIMODALITY CANCER THERAPY; NONHUMAN; REVIEW; SOLID TUMOR; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; DRUG DELIVERY SYSTEMS; GENE THERAPY; GENES, TUMOR SUPPRESSOR; HUMANS; INTERLEUKINS; NEOPLASMS; TECHNOLOGY, PHARMACEUTICAL;

EID: 0037002155     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (48)

1. 281313 GenQuest Inc and Introgen Therapeutics Inc announce gene therapy agreement. GenQuest Inc Press Release 1998 March 16
2. 283232 Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB Oncogene 1995 11 12 2477-2486 Reports the initial discovery and characterization of the mda-7 gene.
3. 298683 Corixa Corporation completes acquisition of GenQuest Inc/Company adds non-vaccine expertise to complement its antigen discovery and growing antibody programs. Corixa Corp Press Release 1998 September 16
4. 314541 Gene causes cancer to reverse course. Bioworld Week 1998 6 48 1
5. 335249 Introgen Therapeutics retains exclusive worldwide license to the mda-7 gene for use in all gene therapy applications. Introgen Therapeutics Inc Press Release 1999 August 04
6. 390029 Introgen preclinical studies demonstrate anti-cancer activity of mda-7 gene therapy - Results presented at the eighth meeting of the European Society of Gene Therapy and published in the Journal of Gene Medicine. Introgen Therapeutics Inc Press Release 2000 November 15
7. 391837 Introgen announces initiation of phase I clinical trial for mda-7 gene therapeutic at SG Cowen's 2nd Annual Health Care Conference. Introgen Therapeutics Inc Press Release 2000 November 30
8. 392670 Introgen presents preclinical results of gene-based anti-angiogenesis therapy data among 5 presentations at the 9th International Conference on Gene Therapy of Cancer. Introgen Therapeutics Inc Press Release 2000 December 07
9. 396750 Introgen awarded grant from National Cancer Institute to evaluate INGN 241 in lung cancer: Results of lung cancer studies published in Gene Therapy. Introgen Therapeutics Inc Press Release 2001 January 24
10. 400256 Introgen receives patent for commercial production of adenovirus. Introgen Therapeutics Inc Press Release 2001 February 27
11. 400834 Introgen's INGN-241 product potentially useful gene therapy for human melanoma study results announced at Fifth World Conference on Melanoma. Introgen Therapeutics Inc Press Release 2001 March 02
12. 404474 Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro. Gene Ther 2000 7 23 2051-2057 Publication describing preclinical trials with lung cancer cells and also examining specific apoptotic pathways.
13. 408612 Introgen publishes preclinical findings demonstrating the potent anti-tumor properties of INGN 241 - Study featured on the cover of Molecular Medicine. Introgen Therapeutics Inc Press Release 2001 May 10
14. 408827 Introgen presents latest research findings at ASCO. Introgen Therapeutics Inc Press Release 2001 May 11
15. 410784 Potent antitumor activity of combined treatment of human breast cancer cells with Ad-mda7 and herceptin or tamoxifen. Mhashilkar A, Zou-Yang H, Sieger K, Kourouma F, Chada S Mol Ther 2001 3 5 (Pt II) Abs 605
16. 429170 Introgen's INGN 241 drug (mda-7) selectively induces cancer cell death; Preclinical results of mda-7 in normal and cancer cells published in Oncogene. Introgen Therapeutics Inc Press Release 2001 November 13
17. 433516 Introgen's INGN 241 gene therapeutic suppresses growth of lung cancer tumors. Introgen Therapeutics Inc Press Release 2001 December 13
18. 433821 New function of cancer gene discovered by Introgen and collaborators at MD Anderson Cancer Center. Introgen Therapeutics Inc Press Release 2001 December 17
19. 434019 Introgen's INGN 241 gene therapy in combination with herceptin in breast cancer shows supra-additive effects. Introgen Therapeutics Inc Press Release 2001 December 18
20. 434034 INGN 241 activates the human immune system in patients with advanced cancer. Introgen Therapeutics Inc Press Release 2001 December 18
21. 436970 Introgen awarded $492,600 grant from the National Cancer Institute to evaluate INGN 241 in melanoma. Introgen Therapeutics Inc Press Release 2002 January 22
22. 446674 Adenoviral-mediated expression of the mda-7 gene sensitizes breast carcinoma cells to ionizing radiation. Liu Y, Nishikawa T, Vorburger SA, Meyn RE, Swisher SG, Chada S, Mirza N, Hunt KK Proc Annu Meet Am Assoc Cancer Res 2002 43 Abs 3209
23. 447095 Adenoviral-mediated mda-7 gene expression radiosensitizes non-small cell lung cancer cells by down-regulating DNA-PK activity. Nishikawa T, Munshi A, Chada S, Meyn Jr RE Proc Annu Meet Am Assoc Cancer Res 2002 43 Abs 3407
24. 447422 MDA-7 induces apoptosis via upregulation of the double stranded-RNA dependent protein kinase (PKR) Pataer A, Vorburger SA, Barber GN, Chada S, Balachandran S, Mhashikar AM, Helena YX, Roth JA, Hunt KK, Swisher SG Proc Annu Meet Am Assoc Cancer Res 2002 43 Abs 5445
25. 447544 Introgen's mda-7 gene therapy product, INGN 241, may work effectively as radiation sensitizer to make cancer cells vulnerable to radiation therapy - Promising preclinical research presented at American Association for Cancer Research Meeting. Introgen Therapeutics Inc Press Release 2002 April 11
26. 447551 Mda-7 gene in Introgen's INGN 241 has dual anti-cancer activity, suggesting unique potential for future cancer treatment - Research presented at American Association for Cancer Research Meeting. Introgen Therapeutics Inc Press Release 2002 April 11
27. 448438 Preclinical study in 'Cancer Research' suggests why Introgen's INGN 241 works effectively as tumor suppressor - Research identifies protein kinase gene as key regulator of cancer drug. Introgen Therapeutics Inc Press Release 2002 April 18
28. 449987 Introgen Therapeutics reports first quarter 2002 results. Introgen Therapeutics Inc Press Release 2002 April 30
29. 451671 A phase I dose-escalation pharmacokinetic and pharmacodynamic study of INGN-241 (Ad-mda7) in patients with advanced solid tumors. Cunningham CC, Richards D, Tong A, Zhang Y, Su D, Chada S, Mhashilkar A, Yang HZ, Parker K, Deborah W, Nemunaities J et al Proc Am Soc Clin Oncol 2001 21 1 Abs 87 Phase I trial showing that INGN-241 was safe and well tolerated as a single intratumoral injection that induced apoptosis in a large percentage of tumor volume.
30. 452130 Introgen's anticancer product INGN 241 yields positive clinical results. Introgen Therapeutics Inc Press Release 2002 May 22
31. 454135 Phase I study shows that single dose of Introgen's INGN 241 kills up to 70% of tumor cells via apoptosis. Introgen Therapeutics Inc Press Release 2002 June 10
32. 455645 Introgen's mda-7 gene therapeutic receives patent. Introgen Therapeutics Inc Press Release 2002 June 20
33. 456063 The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24. Caudell EG, Mumm JB, Poindexter N, Ekmekcioglu S, Mhashilkar AM, Yang XH, Retter MW, Hill P, Chada S, Grimm EA J Immunol 2002 168 12 6041-6046 Details the analysis of inducers of endogenous mda-7/IL-24 from human blood cells and characterization of cytokine function, including antagonistic effects with IL-10.
34. 458219 Cancer Gene Therapy - 11th International Conference, London, UK. IDDB Meeting Report 2002 July 11-12
35. 458302 Preclinical study published in 'Oncogene' shows Introgen's INGN 241 gene therapeutic inhibits growth of lung cancer. Introgen Therapeutics Inc Press Release 2002 July 17
36. 458735 Cutting edge: Immune cells as sources of the IL-10 family members? J Immunol 2002 168 11 5397-5402 Comparative analysis of basal and induced levels in blood mononuclear cells of the IL-10 family of cytokines and their receptors.
37. 458736 A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells. Proc Natl Acad Sci USA 2001 98 18 10332-10337 Studies describing the bystander effect, and in vitro and xenograft studies of mda-7/IL-24 in the context of resistamt pancreatic cancer cells. Downregualtion of mutated k-Ras converts the cells from resistant to susceptible.
38. 458737 Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC J Immunol 2001 167 7 3545-3549 Describes identification of cognate receptors and downstream signal transduction pathways involved in mda-7/IL-24 activity.
39. 458738 Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. Wang M, Tan Z, Zhang R, Kotenko SV, Liang P J Biol Chem 2002 277 9 7341-7347 Describes identification of cognate receptors and downstream signal transduction pathways involved in mda-7/IL-24 activity.
40. 458740 Mda-7/IL-24 mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci USA 2002 99 15 10054-10059 Provides potential clues about the specificity of action, including induction of the GADD genes and involvement of MAPK pathways in mda-7/IL-24-induced cancer cell killing in melanoma.
41. 458929 Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo. Oncogene 2002 21 29 4558-4566 Documents the anti-angiogenic effects of mda-7/IL-24 in lung cancer cells.
42. 469552 The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Su ZZ, Madireddi MT, Lin JJ, Young CS, Kitada S, Reed JC, Goldstein NI, Fisher PB Proc Natl Acad Sci USA 1998 95 24 14400-14405
43. 469560 The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Jiang H, Su ZZ, Lin JJ, Goldstein NI, Young CS, Fisher PB Proc Natl Acad Sci USA 1996 93 17 9160-9165
44. 470616 Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas. Ekmekcioglu S, Ellerhorst J, Mhashilkar AM, Sahin AA, Read CM, Prieto VG, Chada S, Grimm EA Int J Cancer 2001 94 1 54-59
45. 470739 Adenovirus-mediated mda-7 gene expression radiosensitizes non-small cell lung cancer cells via TP53-independent mechanisms. Kawabe S, Nishikawa T, Munshi A, Roth JA, Chada S, Meyn RE Mol Ther 2002 6 5 637-644
46. 472370 Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: Results of a phase I clinical trial. Sung MW, Yehc H-C, Thung SN, Schwartz ME, Mandeli JP, Chen SH, Woo SL Mol Ther 2001 4 3 182-191
47. 4272779 Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. Parrish-Novak J, Xu W, Brender T, Yao L, Jones C, West J, Brandt C, Jelinek L, Madden K, McKernan PA, Foster DC et al J Biol Chem 2002 277 49 47517-47523
48. 472806 Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Pataer A, Vorburger SA, Barber GN, Chada S, Mhashilkar AM, Zou-Young H, Stewart AL, Balachandran S, Roth JA, Hunt KK, Swisher SG Cancer Res 2002 62 8 2239-2243