Homocysteine and the stage of atherosclerotic disease: A study in patients suffering from clinically silent and clinically manifest atherosclerotic disease

European Journal of Clinical Investigation

Volumn 32, Issue 5, 2002, Pages 309-315

  Pasterkamp, G ^a   Algra, A ^a   Grobbee, D E ^a   De Jaegere, P P T ^a   Banga, J D ^a   Van Der Graaf, Y ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Atherosclerosis; Homocysteine; Risk factor

Indexed keywords

CREATININE; HOMOCYSTEINE; VITAMIN;

ADULT; AGE; AGED; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BODY MASS; CARDIOVASCULAR RISK; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FEMALE; HIGH RISK POPULATION; HUMAN; HYPERHOMOCYSTEINEMIA; ISCHEMIC HEART DISEASE; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RISK ASSESSMENT; RISK FACTOR; SCORING SYSTEM; STAGING; SYMPTOM; VITAMIN SUPPLEMENTATION;

ADULT; AGED; ARTERIOSCLEROSIS; CROSS-SECTIONAL STUDIES; FEMALE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; MIDDLE AGED; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 0036998091     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2002.00986.x     Document Type: Article

References (29)

1. Wilcken DEL, Wilcken B. The pathogenesis of coronary artery disease: a possible role for methionine metabolism. J Clin Invest 1976;57:1079-82.
2. Kang S, Wong PWK, Cook HY, Norusis M, Messer JV. Protein bound homocysteine. J Clin Invest 1986;77:1482-1486.
3. Alfthan G, Pekkanen J, Jauhiainen M et al. Relation of serum homocysteine and lipoprotein concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis 1994;106:9-19.
4. Stampfer MJ, Malinow MR, Willett WC et al. A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. JAMA 1992;268:877-81.
5. Arnesen E, Refsum H, Bonaa KH, Ueland PM, Forde OH, Nordrehaug JE. Serum total homocysteine and coronary artery disease. Int J Epidemiol 1995;24:704-9.
6. Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum homocysteine concentration and risk of stroke in middle aged British men. Lancet 1995;346:1395-8.
7. Verhoef P, Hennekens CH, Malinow MR, Kok FJ, Willett WC, Stampfer MJ. A prospective study of plasma homocysteine and risk of ischemic stroke. Stroke 1994;346:1395-8.
8. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997;337:230-6.
9. Wald NJ, Watt HC, Law MR, Weir DG, McPartlin J, Scott JM. Homocysteine and ischemic heart disease. Arch Intern Med 1998;158:862-7.
10. Thambyrajah J, Townend JN. Homocysteine and atherothrombosis - mechanisms for injury. European Heart J 2000;21:967-74.
11. Hajjar KA. Homocysteine: a sulph'rous fire. J Clin Invest 2001;107:663-5.
12. Hofmann MA, Lalla E, Lu Y, Gleason MR, Wolf BM, Tanji N et al. Hyperhomocystenemia enhances vascular inflammation and accelerates vascular inflammation in a murine model. J Clin Invest 2001;107:675-83.
13. Folsom AR, Nieto FJ, McGovern PG, Tsai MY, Malinow MR, Eckfeldt JH et al. Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins. The ARIC Study Circulation 1998;98:204-10.
14. Evans RW, Shaten J, Hempel JD, Cutler JA, Kuller LH for the MRFIT Research group. Homocysteine and risk of cardiovascular disease in the multiple risk factor intervention trial. Arterioscl Thromb Vasc Biol 1997;17:1947-53.
15. Ubbink JB, Fehily AM, Pickering J, Elwood PC, Vermaak WJH. Homocysteine and ischaemic heart disease in the Caerphilly cohort. Atherosclerosis 1998;140:349-56.
16. Brattstrom L, Wilcken DEL. Homocysteine and cardiovascular disease: cause or effect? Am J Clin Nutr 2000;72:315-23.
17. Chasan-Taber L, Selhub J, Rosenberg IH et al. A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians. J Am Coll Nutr 1996;15:136-43.
18. Simons PC, Algra A, van de Laak MF, Grobbee DE, van der Graaf Y. Second manifestations of ARTerial disease (SMART) study: rationale and design. Eur J Epidemiol 1999;15 (9):773-81.
19. Fowkes FGR, Housley E, Cawood EHH, Macintyre CCA, Ruckley CV, Prescott RJ. Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population. Int J Epidemiol 1991;20:384-92.
20. Van Leersum M, van Leeuwen MS, van der Schouw Y, Mali WPTM. New duplex threshold value for angiographically determined stenosis in the internal carotid artery in the light of the NASCET and ECST. Cardiovasc Intervent Radiol 1995;18:S62.
21. Akkersdijk GJM, Puylaert JBCM, de Vries AC. Abdominal aortic aneurysm as an incidental finding in abdominal ultrasonography. Br J Surg 1991;78:1261-3.
22. van der Griend R, Haas FJLM, Duran M, Biesma DH, Meuwissen OJAT, Banga JD. Methionine loading test is necessary for detection of hyperhomocysteinaemia. J Laboratory Clin Med 1998;132:67-72.
23. Simons PC, Algra A, Bots ML, Grobbee DE, van der Graaf Y. Common carotid intima-media thickness and arterial stiffness: indicators of cardiovascular risk in high-risk patients. The SMART Study (Second Manifestations of ARTerial disease). Circulation 1999 August 31;100 (9):951-7.
24. Wall RT, Harlan JM, Harker LA, Striker GE. Homocysteine induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res 1980;18:113-21.
25. Berman RS, Martin W. Arterial endothelial barrier dysfunction: actions of homocysteine and the hypoxanthine-xanthine oxidase free radical generating system. Br J Pharmacol 1993;108:920-6.
26. Upchurch GR, Welch GN, Loscalzo J. Homocysteine, EDRF and endothelial function. J Nutr 1996;126:1290S-1294S.
27. Tsai JC, Perrella MA, Yoshizumi M et al. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci USA 1994;91:6369-73.
28. Dudman NP, Temple SE, Guo XW, Fu W, Perry MA. Homocysteine enhances neutrophil-endothelial interactions in both cultured human cells and rats in vivo. Circ Res 1999;84:409-16.
29. Roest M, van der Schouw YT, Grobbee DE, Tempelman MJ, de Groot PG, Sixma JJ et al. Methylenetetrahydrofolate reductase 677 C/T genotype and cardiovascular disease mortality in postmenopausal women. Am J Epidemiol 2001;153:673-9.