Production of phage-displayed anti-idiotypic antibody single chain variable fragments to MG7 monoclonal antibody directed against gastric carcinoma

Chinese Medical Sciences Journal

Volumn 17, Issue 4, 2002, Pages 215-219

  Fengtian, He ^a   Yongzhan, Nie ^b   Baojun, Chen ^b   Taidong, Qiao ^b   Zheyi, Han ^b   Daiming, Fan ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Anti idiotypic antibody; Gastric carcinoma; Immunotherapy

Indexed keywords

ANTIIDIOTYPIC ANTIBODY; CANCER VACCINE; DNA; KEYHOLE LIMPET HEMOCYANIN; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MG7; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY ENGINEERING; ANTIBODY PRODUCTION; ARTICLE; BASE PAIRING; CANCER IMMUNIZATION; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; DNA VECTOR; ENZYME LINKED IMMUNOSORBENT ASSAY; MOLECULAR CLONING; MOUSE; MOUSE STRAIN; NONHUMAN; PHAGE DISPLAY; PHAGEMID; POLYMERASE CHAIN REACTION; RNA ISOLATION; SPLEEN; STOMACH CARCINOMA;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; BACTERIOPHAGES; CLONING, MOLECULAR; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED BALB C; RNA, MESSENGER; STOMACH NEOPLASMS; VACCINES, DNA;

EID: 0036986833     PISSN: 10019294     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Tripathi PK, Qin H, Deng S, et al. Antigen mimicry by an anti-idiotypic antibody single chain variable fragment. Mol Immunol 1998; 35: 853-863.
2. Yao TJ, Meyers M, Livingston PO, et al. Immunization of melanoma patients with BEC2-keyhole limpet hemocyanin plus BCG intradermally followed by intravenous booster immunizations with BEC2 to induce anti-GD3 ganglioside antibodies. Clin Cancer Res 1999; 5: 77-81.
3. Basak S, Eck S, Gutzmer R, et al. Colorectal cancer vaccines: anti-idiotypic antibody, recombinant protein, and viral vector. Ann NY Acad Sci 2000; 910: 237-253.
4. Maruyama H, Zaloudik J, Li W, et al. Cancer vaccines: single-epitope anti-idiotype vaccine versus multiple-epitope antigen vaccine. Cancer Immunol Immunother 2000; 49: 123-132.
5. Durrant LG, Maxwell-Armstrong C, Buckley D, et al. A neoadjuvant clinical trial in colorectal cancer patients of the human anti-idiotypic antibody 105AD7, which mimics CD55. Clin Cancer Res 2000; 6: 422-430.
6. Reinartz S, Boerner H, Koehler S, et al. Evaluation of immunological responses in patients with ovarian cancer treated with the anti-idiotype vaccine ACA125 by determination of intracellular cytokines - a preliminary report. Hybridoma 1999; 18: 41-45.
7. Fan DM, Zhang XY, Chen XT, et al. Establishment of four monoclonal antibodies to a poorly differentiated gastric cancer cell line MKN-46-9 and immunohistochemical study on their corresponding antigens. J Med Coll PLA 1988; 13: 12-15.
8. Bhattacharya-Chatterjee M, Chatterjee SK, Vasile S, et al. Idiotype vaccines against human T cell leukemia. II. Generation and characterization of a monoclonal idiotype cascade (Ab1, Ab2, and Ab3). J Immunol 1988; 141: 1398-1403.
9. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
10. Durrant LG, Doran M, Austin EB, et al. Induction of cellular immune responses by a murine monoclonal anti-idiotypic antibody recognizing the 791Tgp72 antigen expressed on coloreetal, gastric and ovarian human tumors. Int J Cancer 1995; 61: 62-66.