Effects of benzyltetrahydropalmatine on two components of the delayed rectifier K+ current in guinea pig ventricular myocytes

Cardiovascular Drugs and Therapy

Volumn 16, Issue 4, 2002, Pages 317-325

  Li, Yang ^a   Fu, Li ying ^b   Yao, Weixing ^b   Xia, Guojin ^b   Jiang, Mingxing ^b  

^a Tongji Hospital   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Benzyltetrahydropalmatine; Delayed rectifier potassium current; Myocytes; Patch clamp technique

Indexed keywords

ANTIARRHYTHMIC AGENT; BENZYLTETRAHYDROPALMATINE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DELAYED RECTIFIER POTASSIUM CURRENT; DRUG STRUCTURE; GUINEA PIG; HEART MUSCLE POTENTIAL; HEART PAPILLARY MUSCLE; IC 50; MICROELECTRODE; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; TIME;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BERBERINE ALKALOIDS; CELLS, CULTURED; DELAYED RECTIFIER POTASSIUM CHANNELS; FEMALE; GUINEA PIGS; HEART VENTRICLES; MALE; MYOCYTES, CARDIAC; PAPILLARY MUSCLES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 0036984007     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021781926294     Document Type: Article

References (31)

1. Iost N, Virag L, Opincariu M, Szecsi J, Varro A, Papp JG. Delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc Res 1998;40:508-515.
2. + current. J Gen Physiol 1990;96:195-215.
3. Weixing Y, Guojin X, Jisi Zh, Weizhou Z, Shudong Zh, Mingxing J. A new potassium channel blocker of Chinese medicinal origin-Benzyltetrahydropalmatine. J Tongji Med Univ 1990;10:1-4.
4. Yang L, Lan Ch, Weixing Y, Guojin X, Mingxing J. Effects of benzylenzyltetrahydroalmatine on potassium currents and calcium, sodium currents in guinea pig ventricular myocytes. Acta Pharmaceutica Sin 2000;35(2):85-89.
5. 2+ currents in Purkinje fibers. Acta Pharmacol Sin 1990;11:314-317.
6. Zhang YL, Yang S, Shi NC, Jiang MH. Effects of melittin on isolated papillary muscles of guinea pig. Acta Pharmacol Sin 2001;22(8):697-700.
7. K) in guinea pig ventricular myocytes. Pharmazie 1999;54:61-68.
8. + channels as a mechanism of action of clofilium and d-sotalol in isolated guinea-pig ventricular heart cells. Br J Pharmacol 1999;128:301-312.
9. Balser JR, Bennett PB, Roden DM. Time-dependent outward current in guinea pig ventricular myocytes: Gating kinetics of the delayed rectifier. J Gen Physiol 1990;835-862.
10. Shibaski T. Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J Physiol 1987;387:227-250.
11. Ks in guinea pig isolated ventricular myocytes. Exp Physiol 1996;81:605-614.
12. Noble D, RW Tisen. Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibers. J Physiol 1969;200:205-231.
13. Fermini B, Jurkewicz NK, Jow B, Guinosso Jr PJ, Baskin EP, Lynch Jr. Use dependent effects of class III antiarrhythmic agent NE-10064 (aminilide) on cardiac repolarization: Block of delayed rectifier potassium and L-type calcium current. J Cardiovasc Pharmacol 1995;26:259-271.
14. Ks play a role in the reverse rate dependence of class III agent? Circ Res 1996;78:26-37.
15. Virag L, Iost N, Opincariu M, Szolnoky J, Szecsi J, Bogats G, Szenohradszky P, Varro A, Papp JG. The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc Res 2001;49:790-797.
16. Ks) contribute to the differences in action potential duration in basal left ventricular myocytes in guinea-pig. Cardiovasc Res 1998;40:322-331.
17. + current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc Res 1998;38:441-450.
18. Witchel HJ, Hancox JC. Familial and acquired long QT syndrome and the cardiac rapid delayed rectifier potassium current. Clin Exp Pharmacol Physiol 2000;27:753-766.
19. Falk RH, Decara JM. Dofetilide: A new pure class III antiarrhythmic agent. Am Heart J 2000;140:697-706.
20. Elizalde A, Barajas H, Navarro-Polanco R, Sanchez-Chapula J. Frequency-dependent effects of 4-aminopyridine and almokalant on action-potential duration of adult and neonatal rabbit ventricular muscle. J Cardiovasc Pharmacol 1999;33:352-359.
21. Ks Play a Role in the Reverse Rate Dependence of Class III Agents? Circ Research 1996;78:26-37.
22. Lu HR, Remeysen P, De Clerck F. Nonselective I(Kr)-blockers do not induce torsades de pointes in the anesthetized rabbit during alphal-adrenoceptor stimulation. J Cardiovasc Pharmacol 2000;36:728-736.
23. + current by dofetilide. Circ Research 1993;72:75-83.
24. + current on repolarisation in human and guinea pig ventricular myocytes. Cardiovasc Research 1998;38:441-450.
25. Jisi Z, Weixing Y, Guojin X, Mingxing J, Zengyan H. Antiarrhythmic action of benzyltetrahydropalmatine. Acta Tongji Med Univ 1988;17:188-221
26. Weixing Y, Guojin X, Weizhong Z, Mingxing J. Effects of benzyltetrahydropalmatine on delayed afterdepolarization and triggered activity and rabbit His-Bundle electrogram. Acta Tongji Med Univ 1991;11:20-23.
27. Guojin X, Weixing Y, Xingkai L, Mingxing J. Effect of benzyltetrahydropalmatine on ischemia reperfusion with monophasic action potential. Acta Pharmaceutica Sin 1990;25:293-296.
28. Shuiping D, Weixing Y, Xingkai L, Mingxing J. Effect of benzyltetrahydropalmatine on the action potential and the delayed rectifier potassium current in guinea pig ventricular myocytes. Chin J Pharmacol and Toxicol 1996;10:71-72.
29. Paquette T, Clay JR, Ogbaghebriel A, Shrier A. Effects of divalent cations on the E-4031-sensitive repolarization current, I(Kr), in rabbit ventricular myocytes. Biophys J 1998;74(3):1278-1285.
30. Daleau P, Khalifa M, Turgeon J. Effects of cadmium and nisoldipine on the delayed rectifier potassium current in guinea pig ventricular myocytes. J Pharmacol Exp Ther 1997;281(2):826-833.
31. Yang L, Fang LY, Weixing Y, Guojin X, Mingxing J. Effects of benzylenzyltetrahydroalmatine on transient outward potassium current in rat ventricular myocytes. Chin J Pharmacol and Toxicol 2001;15(5):358-360.