Adjuvant chemotherapy in stage III colon cancer with 5-fluorouracil and levamisole versus 5-fluorouracil and leucovorin

Onkologie

Volumn 25, Issue 5, 2002, Pages 426-430

  Dencausse, Y ^c   Hartung, G ^d   Sturm, J ^d   Kopp Schneider, A ^a   Hagmuller E ^d   Wojatschek, C ^d   Lindemann, H ^b   Fritze, D ^d   Queisser W ^d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b St Marienhospital   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d NONE

Author keywords

5 Fluorouracil; Adjuvant chemotherapy; Colon cancer; Folinic acid (Leucovorin); Levamisole

Indexed keywords

FLUOROURACIL; FOLINIC ACID; LEVAMISOLE;

ADJUVANT CHEMOTHERAPY; ADULT; AGED; ALOPECIA; ANEMIA; ANOREXIA; ARTICLE; CANCER SURVIVAL; CLINICAL TRIAL; COLON CARCINOMA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; FEMALE; HEART ARRHYTHMIA; HUMAN; INFECTION; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEUROTOXICITY; STANDARD; STOMATITIS; TIME; TOXICITY; VOMITING;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; COLONIC NEOPLASMS; DISEASE-FREE SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HUMANS; LEVAMISOLE; MALE; MIDDLE AGED; SURVIVAL ANALYSIS;

EID: 0036979927     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000067436     Document Type: Article

References (13)

1. Moertel CG, Fleming TR, MacDonald JS, Haller DG, Laurie JA, Goodman PJ, Ungerleider JS, Emerson WA, Tormey DC, Glick JH, Veeder MH, Mailliard JA: Levamisole and fluorouracil for adjuvant treatment of resected colon carcinoma. N Engl J Med 1990;322:352-258.
2. International Multicentre Poole Analysis of colon cancer trials (IMPACT) investigators: Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet 1995;345:939-944.
3. Wolmark N, Rockette H, Fisher B, Wickerham DL, Redmond C, Fisher ER, Jones J, Mamounas EP, Ore L, Petrelli NJ: The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: Results from National Surgical Adjuvant Breast and Large Bowel Project Protocol C-03. J Clin Oncol 1993;11:1879-1887.
4. Francini G, Petrioli R, Lorenzini L, Mancini S, Armenio S, Tanzini G, Marsili S, Aquino A, Marzocca G, Civitelli S: Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology 1994;106:899-906.
5. O'Connell MJ, Mailliard JA, Kahn MJ, Macdonald JS, Haller DG, Mayer RJ, Wieand HS: Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer. J Clin Oncol 1997;15:246-250.
6. Zoetmulder FAN, Taal BG, van Tinteren H: Adjuvant 5FU plus levamisole improves survival in stage II and III colonic cancer, but not in rectal cancer. Interim analysis of The Netherlands Adjuvant Colorectal Cancer Project (NACCP). Proc Am Soc Clin Oncol 1999;18:266a (abstr).
7. Mamounas E, Wieand S, Wolmark N, Bear HD, Atkins JN, Song K, Jones J, Rockette H: Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04). J Clin Oncol 1999;17:1349-1355.
8. Haller DG, Catalano PJ, Macdonald JS, Mayer RJ: Fluorouracil (FU), Leucovorin (LV) and Levamisole (LEV) Adjuvant therapy for colon cancer: Five-year final report of INT-0089. Proc Am Soc Clin Oncol 1998;17:982 (abstr).
9. Hartung G, Queisser W: Adjuvant systemic treatment of colorectal cancer: Duration of therapy; in Bleiberg H, Rougier P, Wilke H-J (eds): Management of Colorectal Cancer. London, Dunitz, 1998, pp 167-178.
10. Hartung G, Queisser W, Diezler P, Hagmüller E, Edler L, Jacob I, Wojatschek C, Seifert A, Weiss H, Weh H-J, Hoffknecht M, Clemens MR, Fritze D, Katz R, Härle M for the Study Group Colon and Rectum Carcinoma: Adjuvant chemotherapy with 5-fluorouracil and folinic acid in colorectal cancer: Evaluation of toxicity. Onkologie 1996;19:62-67.
11. Com-Nouges C, Rodary C, Patte C: How to establish equivalence when data are censored: A randomized trial of treatments for B-non-Hodgkin Lymphoma. Stat Med 1993;12:1363-1364.
12. Wellek S: A log-rang test for equivalence of two survivor functions. Biometrics 1993;49:877-881.
13. Queißer W: Zum Dilemma der klinischen Forschung in Deutschland. Onkologie 1996;19:354-359.