Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava)

Planta Medica

Volumn 68, Issue 12, 2002, Pages 1055-1058

  Unger, Matthias ^a   Holzgrabe, Ulrike ^a   Jacobsen, Wolfgang ^b   Cummins, Carolyn ^c   Benet, Leslie Z ^c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID ETHYL ESTER; COMPLEMENTARY DNA; CYTOCHROME P450 3A4; CYTOCHROME P450 3A4 INHIBITOR; CYTOCHROME P450 INHIBITOR; KAVA EXTRACT; KAVALACTONE DERIVATIVE; LACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER INJURY; MASS SPECTROMETRY; NONHUMAN; PLANT; RHIZOME; SOLID;

ANISOLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; KAVA; LACTONES; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PHYTOTHERAPY; PLANT EXTRACTS; PYRANS; PYRONES; RHIZOME;

ANIMALIA; PIPER METHYSTICUM;

EID: 0036971231     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-36360     Document Type: Article

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