Immunophenotype of conjunctival melanomas: Comparisons with uveal and cutaneous melanomas

Archives of Ophthalmology

Volumn 120, Issue 12, 2002, Pages 1625-1629

  Iwamoto, Satori ^a   Burrows, Robert C ^a   Grossniklaus, Hans E ^b   Orcutt, James ^a   Kalina, Robert E ^a   Boehm, Michael ^a   Bothwell, Mark A ^a   Schmidt, Rodney ^a  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELAN A; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HMB 45; MONOCLONAL ANTIBODY HMB 50; MONOPHENOL MONOOXYGENASE; NEUROTROPHIN RECEPTOR; PROTEIN P75; PROTEIN S 100; TRANSCRIPTION FACTOR; TUMOR MARKER; UNCLASSIFIED DRUG;

ANTIBODY LABELING; ARTICLE; CARUNCLE; CLINICAL ARTICLE; CONJUNCTIVA; CONJUNCTIVA MELANOMA; CONJUNCTIVA TUMOR; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOPHENOTYPING; MELANOMA; MICROPHTHALMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; UVEA MELANOMA;

EID: 0036970876     PISSN: 00039950     EISSN: None     Source Type: Journal    
DOI: 10.1001/archopht.120.12.1625     Document Type: Article

References (30)

1. Seregard S. Conjunctival melanoma. Surv Ophthalmol. 1998;42:321-350.
2. Luthra CL, Doxanas MT, Green WR. Lesions of the caruncle: a clinicohistopathologic study. Surv Ophthalmol. 1978;23:183-195.
3. Shields CL, Shields JA. Tumors of the caruncle. Int Ophthalmol Clin. 1993;33: 31-36.
4. Srinivasan BD, Jakobiec FA, Iwamoto T. Conjunctiva. In: Jakobiec FA, ed. Ocular Anatomy, Embryology, and Teratology. Philadelphia, Pa: Harper & Row Publishers; 1982:733-760.
5. Farber M, Schutzer P, Mihm MC Jr. Pigmented lesions of the conjunctiva. J Am Acad Dermatol. 1998;38:971-978.
6. Noden DM. Periocular mesenchyme: neural crest and mesodermal interactions. In: Jakobiec FA, ed. Ocular Anatomy, Embryology, and Teratology. Philadelphia, Pa: Harper & Row Publishers; 1982:97-119.
7. Hogan MJ, Alvarado JA, Weddell JE. Histology of the Human Eye: An Atlas and Textbook. Philadelphia, Pa: WB Saunders Co; 1971:202-392.
8. Folberg R. Melanocytic lesions of the conjunctiva. In: Spencer S, ed. Ophthalmic Pathology: An Atlas and Textbook. Philadelphia, Pa: WB Saunders Co; 1996: 125-155.
9. Neades GT. Clinical presentation and diagnosis of metastasis. In: Miller SJ, Maloney ME, eds. Cutaneous Oncology. Malden, Mass: Blackwell Science Inc; 1998:292-296.
10. Jakobiec FA, Iwamoto T. Ocular adnexa: introduction to lids, conjunctiva, and orbit. In: Jakobiec FA, ed. Ocular Anatomy, Embryology, and Teratology. Philadelphia, Pa: Harper & Row Publishers; 1982:677-731.
11. Jakobiec FA, Folberg R, Iwamoto T. Clinicopathologic characteristics of premalignant and malignant melanocytic lesions of the conjunctiva. Ophthalmology. 1989;96:147-166.
12. Zimmerman LE. The histogenesis of conjunctival melanomas: the first Algon B. Reese Lecture. In: Jakobiec FA, ed. Ocular and Adnexal Tumors. Birmingham, Ala: Aesculapius Publishing Co; 1978:600-630.
13. Silvers DN, Jakobiec FA, Freeman TR, Lefkowitch JH, Elic RC. Melanoma of the conjunctiva: a clinicopathologic study. In: Jakobiec FA, ed. Ocular and Adnexal Tumors. Birmingham, Ala: Aesculapius Publishing Co; 1978:583-599.
14. Iwamoto S, Burrows RC, Kalina RE, et al. Immunophenotypic differences between uveal and cutaneous melanomas. Arch Ophthalmol. 2002;120:466-470.
15. Fuchs U, Kivela T, Liesto K, Tarkkanen A. Prognosis of conjunctival melanomas in relation to histopathological features. Br J Cancer. 1989;59:261-267.
16. Heegaard S, Jensen OA, Prause JU. Immunohistochemical diagnosis of malignant melanoma of the conjunctiva and uvea: comparison of the novel antibody against melan-A with S100 protein and HMB-45. Melanoma Res. 2000;10:350-354.
17. Steuhl KP, Rohrbach JM, Knorr M, Thiel HJ. Significance, specificity, and ultrastructural localization of HMB-45 antigen in pigmented ocular tumors. Ophthalmology. 1993;100:208-215.
18. McDonnell JM, Sun YY, Wagner D. HMB-45 immunohistochemical staining of conjunctival melanocytic lesions. Ophthalmology. 1991;98:453-458.
19. Jay V, Font RL. Conjunctival amelanotic malignant melanoma arising in primary acquired melanosis sine pigmento. Ophthalmology. 1998;105:191-194.
20. Tseng SH, Chen YT, Huang FC, Jin YT. Seborrheic keratosis of conjunctiva simulating a malignant melanoma: an immunocytochemical study with impression cytology. Ophthalmology. 1999;106:1516-1520.
21. Glasgow BJ, McCall LC, Foos RY. HMB-45 antibody reactivity in pigmented lesions of the conjunctiva. Am J Ophthalmol. 1990;109:696-700.
22. Iwamoto S, Burrows RC, Agoff SN, Piepkorn M, Bothwell M, Schmidt R. The p75 neurotrophin receptor, relative to other Schwann cell and melanoma markers, is abundantly expressed in spindled melanomas. Am J Dermatopathol. 2001;23: 288-294.
23. Iwamoto S, Odland PB, Piepkorn M, Bothwell M. Evidence that the p75 neurotrophin receptor mediates perineural spread of desmoplastic melanoma. J Am Acad Dermatol. 1996;35:725-731.
24. Kanik AB, Yaar M, Bhawan J. p75 Nerve growth factor receptor staining helps identify desmoplastic and neurotropic melanoma. J Cutan Pathol. 1996;23:205-210.
25. Wick MR, Swanson PE, Rocamora A. Recognition of malignant melanoma by monoclonal antibody HMB-45: an immunohistochemical study of 200 paraffinembedded cutaneous tumors. J Cutan Pathol. 1988;15:201-207.
26. Carlson JA, Egbert BM. Desmoplastic neurotropic malignant melanoma. Pathology (Phila). 1994;2:339-357.
27. Longacre TA, Egbert BM, Rouse RV. Desmoplastic and spindle-cell malignant melanoma: an immunohistochemical study. Am J Surg Pathol. 1996;20:1489-1500.
28. Blessing K, Sanders D, Grant J. Comparison of immunohistochemical staining of the novel antibody melan-A with S100 protein and HMB-45 in malignant melanoma and melanoma variants. Histopathology. 1998;32:139-146.
29. Granter SR, Weilbaecher KN, Quigley C, Fletcher CD, Fisher DE. Microphthalmia transcription factor: not a sensitive or specific marker for the diagnosis of desmoplastic melanoma and spindle cell (non-desmoplastic) melanoma. Am J Dermatopathol. 2001;23:185-189.
30. King R, Googe PB, Weilbaecher KN, Mihm MC Jr, Fisher DE. Microphthalmia transcription factor expression in cutaneous benign, malignant melanocytic, and nonmelanocytic tumors. Am J Surg Pathol. 2001;25:51-57.