Body composition modulates the effects of hormone replacement therapy on growth hormone and insulin-like growth factor-I levels in postmenopausal women

Gynecologic and Obstetric Investigation

Volumn 54, Issue 4, 2002, Pages 201-206

  Figueroa, Arturo ^a,c   Going, Scott B ^a   Milliken, Laura A ^b   Blew, Robert ^a   Sharp, Sarah ^a   Lohman, Timothy G ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS BOSTON   (United States)

^c SYRACUSE UNIVERSITY   (United States)

Author keywords

Body composition; Hormone profile; Hormone replacement therapy; Menopause; Obesity

Indexed keywords

ANDROSTENEDIONE; ESTRADIOL; ESTROGEN; ESTRONE; GESTAGEN; GROWTH HORMONE; HYDROCORTISONE; SOMATOMEDIN C;

ADULT; AGED; ANDROSTENEDIONE BLOOD LEVEL; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; BODY FAT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DUAL ENERGY X RAY ABSORPTIOMETRY; ESTRADIOL BLOOD LEVEL; ESTRONE BLOOD LEVEL; FEMALE; GROWTH HORMONE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; MULTIPLE REGRESSION; OBESITY; POSTMENOPAUSE; PREVALENCE; PRIORITY JOURNAL; TRUNK;

ADIPOSE TISSUE; ADULT; AGED; BODY COMPOSITION; BODY CONSTITUTION; CROSS-SECTIONAL STUDIES; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ESTRONE; FEMALE; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; INSULIN-LIKE GROWTH FACTOR I; MIDDLE AGED; OBESITY; POSTMENOPAUSE; REGRESSION ANALYSIS;

EID: 0036966867     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000068383     Document Type: Article

References (29)

1. Svendsen OL, Hassager C, Christiansen C: Age- and menopause-associated variation in body composition and fat distribution in healthy women as measured by dual-energy X-ray absorptiometry. Metabolism 1995;44:369-373.
2. Tremollieres FA, Pouilles JM, Ribot CA: Relative influence of age and menopause on total and regional body composition changes in postmenopausal women. Am J Obstet Gynecol 1996;175:1594-1600.
3. Heiss CJ, Sanborn CF, Nichols DL, Bonnick SL, Alford BB: Associations of body fat distribution, circulating sex hormones, and bone density in postmenopausal women. J Clin Endocrinol Metab 1995;80:1591-1596.
4. Marin P, Kvist H, Lindstedt G, Sjostrom L, Bjorntorp P: Low concentrations of insulin-like growth factor-I in abdominal obesity. Int J Obesity 1993;17:83-89.
5. Rasmussen MH, Frystyk J, Andersen T, Breum L, Christiansen JS, Hilsted J: The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone. Metabolism 1994;43:315-319.
6. Roubenoff R, Rall LC, Veldhuis JD, Kehayias JJ, Rosen C, Nicolson M, Lundgren N, Reichlin S: The relationship between growth hormone kinetics and sarcopenia in postmenopausal women: The role of fat mass and leptin. J Clin Endocrinol Metab 1998;83:1502-1506.
7. Albala C, Yanez M, Devoto E, Sostin C, Zeballos L, Santos JL: Obesity as a protective factor for postmenopausal osteoporosis. Int J Obes Relat Metab Disord 1996;20:1027-1032.
8. Parker LN: Control of adrenal androgen secretion. Endocrinol Metab Clin North Am 1991;20:401-421.
9. Pijl H., Langendonk JG, Burggraaf J, Frolich M, Cohen AF, Veldhuis JD, Meinders AE: Altered neuroregulation of GH secretion in viscerally obese premenopausal women. J Clin Endocrinol Metab 2001;86:5509-5515.
10. Veldhuis JD, Iranmanesh A, Ho KK, Waters MJ, Johnson ML, Lizarralde G: Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 1991;72:51-59.
11. Bellantoni MF, Vittone J, Campfield AT, Bass KM, Harman SM, Blackman MR: Effects of oral versus transdermal estrogen on the growth hormone/insulin-like growth factor-1 axis in younger and older postmenopausal women: A clinical research center study. J Clin Endocrinol Metab 1996;81:2848-2853.
12. Paassilta M, Karjalainen A, Kervinen K, Savolainen MJ, Heikkinen J, Backstrom AC, Ke-saniemi YA: Insulin-like growth factor binding protein-1 (IGFBP-1) and IGF-1 during oral and transdermal estrogen replacement therapy: relation to lipoprotein(a) levels. Atherosclerosis 2000;149:157-162.
13. Borski RJ, Tsai W, DeMott-Friberg R, Barkan AL: Regulation of somatic growth and the somatotropic axis by gonadal steroids: Primary effect on insulin-like growth factor-1 gene expression and secretion. Endocrinology 1996;137:3253-3259.
14. Stomati M, Hartmann B, Spinetti A, Mailand D, Rubino S, Albrecht A, Huber J, Petraglia F, Genazzani AR: Effects of hormonal replacement therapy on plasma sex hormone-binding globulin, androgen and insulin-like growth factor-1 levels in postmenopausal women. J Endocrinol Invest 1996;19:535-541.
15. Gambacciani M, Ciaponi M, Cappagli B, De Simone L, Orlandi R, Genazzani AR: Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy. Maturitas 2001;39:125-132.
16. Haarbo J, Marslew U, Gotfredsen A, Christiansen C: Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism 1991;40:1323-1326.
17. Thompson JL, Butterfield GE, Marcus R, Hintz RL, Van Loan M, Ghiron L, Hoffman AR: The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women. J Clin Endocrinol Metab 1995;80:1845-1852.
18. Maccario M, Tassone F, Grottoli S, Rossetto R, Gauna C, Ghigo E: Neuroendocrine and metabolic determinants of the adaptation of GH/IGF-1 axis to obesity. Ann Endocrinol 2002;63:140-144.
19. Burleson MH, Malarkey WB, Cacioppo JT, Poehlmann KM, Kiecolt-Glaser JK, Berntson GG, Glaser R: Postmenopausal hormone replacement: Effects on autonomic, neuroendocrine, and immune reactivity to brief psychological stressors. Psychosom Med 1998;60:17-25.
20. Tazuke S, Khaw KT, Barrett-Connor E: Exogenous estrogen and endogenous sex hormones. Medicine 1992;71:44-51.
21. Grenman S, Ronnemaa T, Irjala K, Kaihola HL, Gronroos M: Sex steroid, gonadotropin, cortisol, and prolactin levels in healthy, massively obese women: Correlation with abdominal fat cell size and effect of weight reduction. J Clin Endocrinol Metab 1986;63:1257-1261.
22. Nolten WE, Lindheimer MD, Rueckert PA, Oparil S, Ehrlich EN: Diurnal patterns and regulation of cortisol secretion in pregnancy. J Clin Endocrinol Metab 1980;51:466-472.
23. Rosenthal HE, Slaunwhite WR Jr, Sandberg AA: Transcortin: A corticosteroid-binding protein of plasma. X. Cortisol and progesterone interplay and unbound levels of these steroids in pregnancy. J Clin Endocrinol Metab 1969;29:352-337.
24. Frystyk J, Vestbo E, Skjaerbaek C, Mogensen CE, Orskov H: Free insulin-like growth factors in human obesity. Metabolism 1995;44:37-44.
25. Marin P, Darin N, Amemiya T, Andersson B, Jern S, Bjorntorp P: Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 1992;41:882-886.
26. Ryan AS, Nicklas BJ, Berman DM: Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women. Diabetes Care 2002;25:127-133.
27. Szymczak J, Milewicz A, Thijssen JH, Blankenstein MA, Daroszewski J: Concentration of sex steroids in adipose tissue after menopause. Steroids 1998;63:319-321.
28. Pedersen SB, Hansen PS, Lund S, Andersen PH, Odgaard A, Richelsen B: Identification of oestrogen receptors and oestrogen receptor mRNA in human adipose tissue. Eur J Clin Invest 1996;26:262-269.
29. Forbes GB: Lean body mass-body fat interrelationships in humans. Nutr Rev 1987;45:225-231.