Structural alterations of plasma membranes of Guerin's carcinoma cells upon the development of resistance to doxorubicine

Experimental Oncology

Volumn 24, Issue 4, 2002, Pages 279-283

  Chekhun, V F ^a   Lebed, O I ^b   Tryndyak, V P ^a   Makovetskiy, V P ^b   Todor, I N ^a   Kulik, G I ^a  

^a R E KAVETSKY INSTITUTE OF EXPERIMENTAL PATHOLOGY   (Ukraine)

^b STATE INSTITUTION NATIONAL RESEARCH CENTER FOR RADIATION MEDICINE OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE   (Ukraine)

Author keywords

Doxorubicine; Drug resistance; Fluorescent methods; Membrane structure; Tumor

Indexed keywords

DOXORUBICIN; MEMBRANE LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; CELL MEMBRANE; CONTROLLED STUDY; GUERIN TUMOR; LIPID COMPOSITION; MALE; MEMBRANE STRUCTURE; NONHUMAN; RAT; VISCOSITY;

EID: 0036966101     PISSN: 02043564     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Weinstein-Oppenheimer CR, Henriquez-Roldan CF, Davis JM, Navolanic PM, Saleh OA, Steelman LS, Franklin RA, Robinson PJ, McMahon M, Mc-Cubrey JA. Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin. Clin Cancer Res 2001; 7: 2898-907.
2. Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nature Rev Cancer 2002; 2: 48-58.
3. Ueda K, Yoshida A, Amachi T. Recent progress in P-glycoprotein research. Anticancer Drug Design 1999; 14: 115-21.
4. Kukhar' VP, Luik AI, Mogilevich SE, Radchenko IV, Kibir'ev VK, Skryma RN, Sorochinskij AE, Galushko SV, Kornilov AM, Lebed' OI. Chemistry of bioregulatory processes. Kukhar' VP, Luik AI, eds. Kiev: Naukova duinka, 1992. 367 p. (In Russian).
5. Lebed' OI, Jirnov VV, Zueva NA, Shevehuk VT, Gorchakova NA. Structural effects of sarcolemma of cardiomyocytes upon the action of modulators of polyphosphoinositide system. Physiol Zh USSR 1990; 76: 1290-5 (In Russian).
6. Lebed' OI, Jirnov VV, Jila VA. Structural alterations in membranes of proliferating L-41 leucocytes upon the action of low dose irradiation. Ukr Biochem Zh 1997; 69: 70-8 (In Russian).
7. Chekhun VF, Voitsitskiy VM, Mikhailenko VM, Bulkevich RI, Kulik GI. The influence of coordinated platina compounds on physiko-chemical parameters of artificial plasma membranes. Biol Membranes 1993; 10: 641-6 (In Russian).
8. Lebed' OI, Chekhun VF, Kulik GI. Structural properties of plasmalemma of hepatocytes upon the action of cisplatine, adriablastine and embihine. Exp Oncol 1997; 19: 338-42 (In Russian).
9. Jedrzejczak M, Koceva-Chyla A, Gwozdzinski K, Jozwiak Z. Changes in plasma membrane fluidity of immortal rodent cells induced by anticancer drugs doxorubicin, aclarubicin and mitoxantrone. Cell Biol Int 1999; 23: 497-506.
10. Drori S, Eytan GD, Assaraf YG. Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability. Eur J Biochem 1995; 228: 1020-9.
11. Van Amelsvoort JMM, Sips HJ, van Dam K. Sodium-dependent alanine transport in plasma-membrane vesicles from rat liver. Biochem J 1978; 174: 1083-6.
12. Matlieb MA. Characterization of membrane fractions and isolation of purified plasma membrane from myometrium. J Biol Chem 1974; 254: 1834-40.
13. Rathbun WB, Betlach MV. Estimation of enzymically produced orthophosphate in the presence of cysteine and adenosie triphosphate. Analyt Biochem 1969; 28: 336-46.
14. Greenberg Ph, Craddock R. Rapid single step membrane protein assay. Clin Chem 1982; 27: 1725-9.
15. Burshtein EA. Fluorescence of proteins. Itogi Nauki Techn (Ser. Biophys). Moskow: VINITI, 1977. 7 189 p. (In Russian)
16. Dobretsov GE. Fluorescent probes in the research of cells, membranes and lipoproteins. Moskow: Nauka, 1987. 240 p. (In Russian).