Bilateral adrenal swelling as a cause of chest, back, and upper abdominal pain in essential thrombocythemia and polycythemia vera is due to microvascular ischemic thrombosis rather than to hemorrhage

Annals of Hematology

Volumn 81, Issue 12, 2002, Pages 691-694

  Michiels, J J ^a,c   Berneman, Z ^a   Schroyens, W ^a   Krestin, G P ^b  

^a ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c Goodheart Institute   (Netherlands)

Author keywords

Bilateral adrenal hemorrhage; Bilateral adrenal swelling; Essential thrombocythemia; Microvascular thrombosis; Polycythemia vera

Indexed keywords

ACETYLSALICYLIC ACID; ANAGRELIDE; ATENOLOL; BUSULFAN; CONTRAST MEDIUM; CORTICOSTEROID; DILTIAZEM; ENALAPRIL; HEPARIN; HYDROXYUREA; INTERFERON;

ABDOMINAL PAIN; ADRENAL HEMORRHAGE; ADULT; AGED; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BACKACHE; BLEEDING; BRAIN ISCHEMIA; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CRITICAL ILLNESS; DRUG EFFICACY; EDEMA; GANGRENE; HUMAN; HYPOTENSION; INFARCTION; ISCHEMIC HEART DISEASE; LOW DRUG DOSE; MICROVASCULAR ISCHEMIA; POLYCYTHEMIA VERA; PRIORITY JOURNAL; SEPSIS; THORAX PAIN; THROMBOCYTOPENIA; THROMBOSIS;

ABDOMINAL PAIN; ADRENAL GLAND DISEASES; BACK PAIN; CHEST PAIN; EDEMA; HEMORRHAGE; HUMANS; INFLAMMATION; ISCHEMIA; MICROCIRCULATION; PAIN; POLYCYTHEMIA VERA; THROMBOCYTHEMIA, HEMORRHAGIC; THROMBOSIS;

EID: 0036961384     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-002-0500-5     Document Type: Article

References (20)

1. Kovacs KA, Lam YM, Pater JL (2001) Bilateral massive adrenal hemorrhage. Assessment of putative risk factors by the case-control method. Medicine 80:45-53
2. Vella A, Nippoldt TB, Morris JC (2001) Adrenal hemorrhage: a 25-year experience at the Mayo Clinic. Mayo Clin Proc 76:161-168
3. Kojima K, Takata S, Tezen T, Motikawa T, Itoshima T, Shinagawa K, Tanimoto M (2002) Bilateral adrenal hemorrhage in essential thrombocythemia. Ann Hematol 81:350-351
4. Gelfand ML (1992) Bilateral adrenal hemorrhage in polycythemia vera. N Y State J Med 92:362-363
5. Rao RH (1995) Bilateral massive adrenal hemorrhage. Med Clin North Am 79:107-129
6. Anderson KC, Kuhajda FP, Bell WR (1981) Diagnosis and treatment of anticoagulant-related adrenal hemorrhage. Am J Hematol 11:379-385
7. Winternitz WW (1983) Adrenal hemorrhage complicating anticoagulant therapy. South Med J 76:1369-1371
8. Szabo S, Huttner I, Kovacs K, Horvath E, Szabo D, Horner HC (1980) Pathogenesis of experimental adrenal hemorrhagic necrosis (apoplexy). Ultrastructural, biochemical, neuropharmacologic and blood coagulation studies with acrolonitrile in the rat. Lab Invest 42:533-545
9. Michiels JJ, Ten Kate FWJ, Vuzevski VD, Abels J (1984) Histopathology of erythromelalgia in thrombocythemia. Histopathology 8:669-678
10. Michiels JJ, Ables J, Steketee J, Vuzevski VD, van Vliet HHDM (1985) Erythromelalgia caused by platelet-mediated arteriolar inflammation and thrombosis in thrombocythemia. Ann Intern Med 102:466-471
11. Van Genderen PJJ, Michiels JJ (1997) Erythromelalgia: a pathognomonic microvascular thrombotic complication in essential thrombocythemia and polycythemia vera. Semin Thromb Hemost 23:357-363
12. Michiels JJ, Berneman Z, Schroyens W, van Urk H (2002) Aspirin-responsive painful red, blue, black toe or finger syndrome in thrombocythemia associated with polycythemia vera in maintained remission by bloodletting. Ann Hematol (In press)
13. Michiels JJ (1999) Acquired von Willebrand disease due to increasing platelet count can readily explain the paradox of thrombosis and bleeding in thrombocythemia. Clin Appl Thromb Hemost 5:147-151
14. Michiels JJ (1999) Aspirin and platelet-lowering agents for the prevention of vascular complications in essential thrombocythemia. Clin Appl Thromb Hemost 5:247-251
15. Huch Böni RA, Debatin JF, Krestin GP (1996) Contrastenhanced MR imaging of the kidneys and adrenal glands. MRI Clin North Am 4:101-131
16. Krestin GP, Dunninck NR (2002) Adrenal disease. Eur Radiol (In press)
17. Michiels JJ, Koudstaal PJ, Mulder AH, van Vliet HHDM (1993) Transient neurologic and ocular manifestations in primary thrombocythemia. Neurology 43:1107-1110
18. Michiels JJ, Van Genderen PJJ, Janssen PHP, Koudstaal PJ (1996) Atypical transient ischemic attacks in thrombocythemia of various myeloproliferative disorders. Leuk Lymphoma 22:65-70
19. Scheffer MG, Michiels JJ, Simoons ML, Roelandt JRTC (1991) Thrombocythemia and coronary artery disease. Am Heart J 122:573-576
20. Michiels JJ, Van Genderen PJJ, Lindemans J. van Vliet HHDM (1996) Erythromelalgic, thrombotic and hemorrhagic manifestations in 50 cases of thrombocythemia. Leuk Lymphoma 22:47-56