Is the isonicotinoyl radical generated during activation of isoniazid by MnIII-pyrophosphate?

Comptes Rendus Chimie

Volumn 5, Issue 3, 2002, Pages 325-330

  Nguyen, Michel ^a   Claparols, Catherine ^a   Bernadou, Jean ^a   Meunier, Bernard ^a  

^a LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

Author keywords

Isoniazid; Isonicotinoyl radical; MnIII pyrophosphate; Oxidative activation; Tuberculosis

Indexed keywords

ALDEHYDE DERIVATIVE; ARGON; ISONIAZID; ISONICOTINAMIDE; ISONICOTINIC ACID; ISOTOPE; MANGANESE DERIVATIVE; OXYGEN; PYROPHOSPHORIC ACID DERIVATIVE; TUBERCULOSTATIC AGENT; WATER;

ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL BOND; CHEMICAL COMPOSITION; CHEMICAL REACTION; DRUG OXIDATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; STOICHIOMETRY;

EID: 0036959728     PISSN: 16310748     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1631-0748(02)01370-x     Document Type: Article

References (18)

1. K. Bartmann, H. Iwainski, H.H. Kleeberg, H.H. Mison, P. Offe, H. Otten, D. Tettenborn, L. Trnka, in: K. Bartmann (Ed.), Antituberculosis Drugs, Springer Verlag, Berlin, 1988.
2. J.S. Blanchard, Annu. Rev. Biochem. 65 (1996) 215.
3. K. Johnsson, P.G. Schultz, J. Am. Chem. Soc. 116 (1994) 7425.
4. Y. Zhang, B. Heym, B. Allen, D. Young, S. Cole, Nature 358 (1992) 591.
5. J.A. Marcinkeviciene, R.S. Magliozzo, J.S. Blanchard, J. Biol. Chem. 270 (1995) 22290.
6. K. Johnsson, W.A. Froland, P.G. Schultz, J. Biol. Chem. 272 (1997) 2834.
7. J.Y. Wang, R.M. Burger, K. Drlica, Antimicrob. Agents Chemother. 42 (1998) 709.
8. K. Johnsson, D.S. King, P.G. Schultz, J. Am. Chem. Soc. 117 (1995) 5009.
9. A. Banerjee, E. Dubnau, A. Quémard, V. Balasubramanian, K. Sun Um, T. Wilson, D. Collins, G. Lisle de, W.R. Jacobs Jr, Science 263 (1994) 227.
10. A. Quémard, A. Dessen, M. Sugantino, W.R. Jacobs Jr, J.C. Sacchetini, J.S. Blanchard, J. Am. Chem. Soc. 118 (1996) 1561.
11. M. Daffé, P. Draper, Adv. Microb. Physiol. 39 (1998) 131.
12. H. Marrakchi, G. Laneelle, A. Quémard, Microbiology 146 (2000) 289.
13. D.A. Rozwarski, G.A. Grant, D.H.R. Barton, W.R. Jacobs Jr., J.C. Sacchettini, Science 279 (1998) 98.
14. M. Nguyen, C. Claparols, J. Bernadou, B. Meunier, ChemBioChem 2 (2001) 877.
15. M. Nguyen, A. Quémard, H. Marrakchi, J. Bernadou, B. Meunier, C. R. Acad. Sci. Paris, Ser. IIc 4 (2001) 35.
16. N.L. Wengenack, F. Rusnak, Biochemistry 40 (2001) 8990.
17. J. Bodiguel, J.L. Nagy, K.A. Brown, B. Jamart-Gregoire, J. Am. Chem. Soc. 123 (2001) 3832.
18. F.S. Archibald, I. Fridovich, Arch. Biochem. Biophys. 214 (1982) 452.