Hepatocytes transgenic for the full hepatitis C virus open reading frame are resistant to fas-induced cell death

Annals of the New York Academy of Sciences

Volumn 973, Issue , 2002, Pages 214-217

  Disson, Olivier ^a   Hahne, Michael ^b   Hibner, Urszula ^a   Lerat, Hervé ^a  

^a INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Apoptosis; CD95; Fas; HCV; Hepatitis C virus; Primary hepatocytes; Transgenic mouse

Indexed keywords

FAS ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; LIVER CELL; LIVER HEMORRHAGE; LIVER MITOCHONDRION; MOUSE; NONHUMAN; OPEN READING FRAME; TRANSGENE; TRANSGENIC MOUSE;

ANIMALIA; HEPATITIS C VIRUS; MUS MUSCULUS;

EID: 0036959573     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04635.x     Document Type: Conference Paper

References (4)

1. LERAT, H., M. HONDA, M. BEARD, et al. 2002. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 122: 352-365.
2. OGASAWARA, J., R. WATANABE-FUKUNAGA, M. ADACHI, et al. 1993. Lethal effect of the anti-Fas antibody in mice. Nature 364: 806-809.
3. HATANO, E., C.A. BRADHAM, A. STARK, et al. 2000. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. J. Biol. Chem. 275: 11814-11823.
4. RAVAGNAN, L., I. MARZO, P. COSTANTINI, et al. 1999. Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore. Oncogene 18: 2537-2546.