A multihormonal pituitary adenoma with growth hormone and adrenocorticotropic hormone production, causing acromegaly and Cushing disease

American Journal of the Medical Sciences

Volumn 324, Issue 6, 2002, Pages 326-330

  Kageyama, Kazunori ^a   Nigawara, Takeshi ^a   Kamata, Yoshimasa ^a   Terui, Ken ^a   Anzai, Jiichi ^a   Sakihara, Satoru ^a   Suda, Toshihiro ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

Acromegaly; Corticotropin (ACTH); Cushing disease; Growth hormone; Pituitary tumor

Indexed keywords

CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; GROWTH HORMONE; INSULIN; PROTIRELIN; SOMATOMEDIN C;

ACROMEGALY; ADULT; ARTICLE; CASE REPORT; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN TEST; CUSHING DISEASE; CUSHINGOID SYNDROME; DEXAMETHASONE SUPPRESSION TEST; FEMALE; GENETIC ANALYSIS; GROWTH HORMONE BLOOD LEVEL; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE IMAGING; TRANSSPHENOIDAL SURGERY;

EID: 0036949418     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000441-200212000-00007     Document Type: Article

References (13)

1. Arita K, Uozumi T, Kuwabara S, et al. A case of pituitary adenoma producing both growth hormone (GH) and adrenocorticotropic hormone (ACTH). Endocrinol Jpn 1991; 271-8.
2. Blevins LS, Hall GS, Madoff DH, et al. Acromegaly and Cushing's disease in a patient with synchronous pituitary adenomas. Am J Med Sci 1992;304:294-7.
3. Apel RL, Wilson RJ, Asa SL. A composite somatotrophcorticotroph pituitary adenoma. Endocrinol Pathol 1994;5: 240-6.
4. Kovacs K, Horvath E, Stefaneanu L, et al. Pituitary adenoma producing growth hormone and adrenocorticotropin: a histological, immunocytochemical, electron microscopic, and in situ hybridization study. J Neurosurg 1998;88:1111-5.
5. McCance DR, Gordon DS, Fannin TF, et al. Assessment of endocrine function after transsphenoidal surgery for Cushing's disease. Clin Endocrinol (Oxf) 1993;38:79-86.
6. Imaki T, Tsushim a T, Hizuka N et al. Postoperative plasma cortisol levels predict long-term outcome in patients with Cushing's disease and determine which patients should be treated with pituitary irradiation after surgery. Endocr J 2001;48:53-62.
7. Heitz PU. Multi hormonal pituitary adenomas. Horm Res 1979;10:1-13.
8. Horvath E, Kovacs K. Pituitary gland. Pathol Res Pract 1988;183:129-42.
9. Kageyama K, Nigawara T, Kamata Y et al. A case of macroprolactinoma with subclinical growth hormone production. Endocr J 2002;49:41-7.
10. Osamura YR, Tahara S, Kurotani R, et al. Contributions of immunohistochemistry and in situ hybridization to the functional analysis of pituitary adenomas. J Histochem Cytochem 2000;48:445-58.
11. Matsuno A, Sasaki T, Mochizuki T, et al. A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone-an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture. Acta Neurochir (Wien) 1996;138:1002-7.
12. Thorner MO, Vance ML, Laws ER, et al. The anterior pituitary. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, editors. Williams' textbook of endocrinology, 9th ed. Philadelphia: WB Saunders; 1998. p. 249-340.
13. Nasushita R, Watanobe H, Goto T, et al. A case of acromegaly accompanied by adrenal preclinical Cushing's syndrome. Endocr J 1999;46:133-7.