A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone: An adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture

Acta Neurochirurgica

Volumn 138, Issue 8, 1996, Pages 1002-1007

  Matsuno, A ^a,d   Sasaki, T ^a   Mochizuki, T ^a   Fujimaki, T ^a   Sanno, N ^b   Osamura, Y ^b   Teramoto, A ^c   Kirino, T ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b TOKAI UNIVERSITY   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

^d TEIKYO UNIVERSITY   (Japan)

Author keywords

Adrenocorticotropic hormone; Hypersecretion; Plurihormonal; Primordial stem cell; Somatotroph adenoma

Indexed keywords

CORTICOTROPIN; FOLLITROPIN; GROWTH HORMONE; LUTEINIZING HORMONE; MESSENGER RNA; PROLACTIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PIT 1;

ADULT; ALPHA CHAIN; ARTICLE; CASE REPORT; CELL CULTURE; CORTICOTROPIN RELEASE; FOLLITROPIN RELEASE; GROWTH HORMONE RELEASE; HISTOGENESIS; HORMONE RELEASE; HUMAN; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUTEINIZING HORMONE RELEASE; MALE; MESSENGER RNA SYNTHESIS; PRIORITY JOURNAL; PROLACTIN RELEASE; PROTEIN EXPRESSION; SOMATIC CELL; STEM CELL;

EID: 0029777526     PISSN: 00016268     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01411291     Document Type: Article

References (28)

1. Alexander JM, Biller BMK, Bikkal H, Zervas NT, Arnold A, Klibanski A (1990) Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest 86: 336-340
2. Arita K, Uozumi T, Kuwabara S, Mukada K, Kawamoto K, Takechi A, Onda J, Hara H, Egusa G (1991) A case of pituitary adenoma producing both growth hormone (GH) and adrenocorticotropic hormone (ACTH). Endocrinol Jpn 38: 271-278
3. Asa SL, Kovacs K, Horvath E, Singer W, Smyth HS (1992) Hormone secretion in vitro by plurihormonal pituitary adenomas of the acidophil cell line. J Clin Endocrinol Metab 75: 68-75
4. Biller BMK, Alexander JM, Zervas NT, Hedley-Whyte ET, Arnold A, Klibanski A (1992) Clonal origins of adrenocorticotropin-secreting pituitary tissue in Cushing's disease. J Clin Endocrinol Metab 75: 1303-1309
5. Bugalho MJGM, Nunes JFM, Sobrinho LG, Medina E, Campos JAM, da Silva CG, Clode AL (1993) Multihormonal response to CRH in a patient with Cushing's syndrome and a pituitary adenoma producing ACTH and GH. Acta Endocrinol 128: 289-292
6. Chatelain A, Dupouy JP, Dubois MP (1979) Ontogenesis of cells producing polypeptide hormones (ACTH, MSH, LPH, GH, prolactin) in the fetal hypophysis of the rat: influence of the hypothalamus. Cell Tissue Res 196: 409-427
7. Clore JN, Sharpe AR, Sahni KS, Kovacs K, Blackard WG (1988) Thyrotropin-induced hyperthyroidism: evidence for a common progenitor stem cell. Am J Med Sci 295: 3-5
8. Fukamachi Y, Yokoyama Y, Miyasato H, Matsusaki I, Kanzaki K, Tanaka H, Nawada S, Ibayashi H (1988) A case of Cushing's disease presenting with hypersecretion of GH and PRL five years after adrenalectomy. Clin Endocr (Tokyo) [Suppl 9] 35: 2123 (Jpn)
9. Gicquel C, Bouc YL, Luton JP, Girard F, Bertagna X (1992) Monoclonality of corticotroph macroadenomas in Cushing's disease. J Clin Endocrinol Metab 75: 472-475
10. Herman V, Fagin J, Gonsky R, Kovaes K, Melmed S (1990) Clonal origin of pituitary adenomas. J Clin Endocrinol Metab 71: 1427-1433
11. Jacoby LB, Hedley-Whyte ET, Pulaski K, Seizinger BR, Martuza RL (1990) Clonal origin of pituitary adenomas. J Neurosurg 73: 731-735
12. Kovacs K, Horvath E (1986) Tumors of the pituitary gland. In: Hartmann WH (eds) Atlas of tumor pathology. Second series. Fascicle 21. Armed Forces Institute of Pathology, Washington, pp 70-93
13. Kovacs K, Lloyd RV, Horvath E, Asa SL, Stetaneanu L, Killinger DW, Smyth HS (1989) Silent somatotroph adenomas of the human pituitary. Am J Pathol 134: 345-353
14. Karin M, Castrillo JL, Theill LE (1990) Growth hormone gene regulation: a paradigm for cell-type-specific gene activation. Trends Genet 6: 92-96
15. Li J, Stefaneanu L, Kovacs K, Horvath E, Smyth HS (1993) Growth hormone (GH) and prolactin (PRL) gene expression and immunoreactivity in GH- and PRL-producing human pituitary adenomas. Virchows Archiv A Pathol Anat 422: 193-201
16. Lloyd RV, Cano M, Chandler WF, Barkan AL, Horvath E, Kovacs K (1989) Human growth hormone and prolactin secreting pituitary adenomas atialyzed by in situ hybridization. Am J Pathol 134: 605-613
17. Lloyd RV, Jin L, Fields K, Chandler WF, Horvath E, Stefaneanu L, Kovacs K (1991) Analysis of pituitary hormones and chromogranin A mRNAs in null cell adenomas, oncocytomas, and gonadotroph adenomas by in situ hybridization. Am J Pathol 139: 553-564
18. Matsutio A, Teramoto A, Takekoshi S, Sanno N, Osamura RY, Kirino T (1995) Expression of plurihormonal mRNAs in somatotroph adenomas detected using a non-isotopic in situ hybridization method: comparison with lactotroph adenomas. Hum Pathol 26: 272-279
19. Matsuno A, Teramoto A, Takekoshi S, Sanno N, Osamura RY, Kirino T (1995) HGH, PRL and ACTH gene expression in clinically non-functioning adenomas detected with non-isotopic in situ hybridization method. Endocr Pathol 6: 13-20
20. Matsuno A, Teramoto A, Takekoshi S, Utsunomiya H, Ohsugi Y, Kishikawa S, Osamura RY, Kirino T, Lloyd RV (1994) Application of biotinylated oligonucleotide probes to the detection of pituitary hormone mRNA using Northern blot analysis, in situ hybridization at light and electron microscopic levels. Histochem J 26: 771-777
21. Müller OA, Fink R, Werder KV, Scriba PC (1978) Hypersecretion of ACTH, growth hormone and prolactin in a patient with pituitary adenoma. Acta Endocrinol [Suppl 215] 87: 4-5
22. Sanno N, Inada K, Utsunomiya H, Umemura S, Itoh Y, Matsuno A, Teramoto A, Osamura RY (1994) Expression of Pit-1 product in human pituitaries: histochemical studies using an antibody against synthetic human Pit-1 protein. Med Sci Res 22: 685-687
23. Sanno N, Teramoto A, Matsuno A, Takekoshi S, Osamura RY (1996) Studies on GH and PRL gene expression by non-radioisotopic in situ hybridization in TSH-secreting adenomas. J Clin Endocrinol Metab 80: 2518-2522
24. Scanarini M, Mingrino S (1979) Pituitary adenomas secreting more than two hormones. Acta Neuropathol 48: 67-72
25. Schulte HM, Oldfield EH, Allolio B, Katz DA, Berkman RA, Ali IU (1991) Clonal composition of pituitary adenomas in patients with Cushing's disease: determination by X-chromosome inactivation analysis. J Clin Endocrinol Metab 73: 1302-1308
26. Simmoms DM, Voss JM, Ingraham HA, Holloway JM, Broide RS, Rosenfeld MG, Swanson LW (1990) Pituitary cell phonotypes involve cell-specific Pit-1 mRNA transformation and synergistic interactions with other classes of transcription factors. Genes Dev 4: 695-711
27. Song J, Jin L, Lloyd RV (1989) Effects of estradiol on prolactin and growth hormone messenger RNAs in cultured normal and neoplastic (M1T/W15 and GH3) rat pituitary cells. Cancer Res 49: 1247-1253
28. Thaper K, Stefaneanu L, Kovacs K, Horvath E, Asa SL (1993) Plurihormonal pituitary tumors: beyond the one cell-one hormone theory. Endocr Pathol 4: 1-3