Epididymal cribriform hyperplasia with nuclear atypia in p53 homozygous knockout mice on a mixed 129/Sv-FVB/N background

Comparative Medicine

Volumn 52, Issue 6, 2002, Pages 568-571

  La Perle, Krista M D ^a   Blomme, Eric A G ^a   Sagartz, John E ^a   Capen, Charles C ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CARCINOEMBRYONIC ANTIGEN; PROTEIN P53; PROTEIN S 100;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ULTRASTRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EPIDIDYMAL CRIBRIFORM HYPERPLASIA; EPIDIDYMIS DISEASE; GERM CELL; HOMOZYGOSITY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MALE; MITOSIS; MOUSE; MOUSE STRAIN; NONHUMAN; PREVALENCE; TESTIS TUMOR;

EID: 0036948110     PISSN: 00236764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Donehower, L. A. 1996. The p53-deficient mouse: a model for basic and applied cancer studies. Semin. Cancer Biol. 7:269-278.
2. Donehower, L. A., M. Harvey, B. L. Slagle, M. J. McArthur, C. A. Montgomery, Jr., J. S. Butel, and A. Bradley. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356:215-221.
3. Donehower, L. A., M. Harvey, H. Vogel, M. J. McArthur, C. A. Montgomery, Jr., S. H. Park, T. Thompson, R. J. Ford, and A. Bradley. 1995. Effects of genetic background on tumorigenesis in p53-deficient mice. Mol. Carcinog. 14:16-22.
4. Harvey, M., M. J. McArthur, C. A. Montgomery, Jr., A. Bradley, and L. A. Donehower. 1993. Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J. 7:938-943.
5. Harvey, M., M. J. McArthur, C. A. Montgomery, Jr., J. S. Butel, A. Bradley, and L. A. Donehower. 1993. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat. Genet. 5:225-229.
6. Jacks, T., L. Remington, B. O. Williams, E. M. Schmitt, S. Halachmi, R. T. Bronson, and R. A. Weinberg. 1994. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4:1-7.
7. Li, F. P., J. F. Fraumeni, Jr., J. J. Mulvihill, W. A. Battner, M. G. Dreyfus, M. A. Tucker, and R. W. Miller. 1988. A cancer family syndrome in twenty-four kindreds. Canc. Res. 48:5358-5362.
8. Rotter, V., D. Schwartz, E. Almon, N. Goldfinger, A. Kapon, A. Meshorer, L. A. Donehower, and A. J. Levine. 1993. Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome. Proc. Natl. Acad. Sci. U.S.A. 90:9075-907.
9. Mitsumori, K. and M. R. Elwell. 1988. Proliferative lesions in the male reproductive system of F344 rats and B6C3F1 mice: incidence and classification. Environ. Health. Perspect. 77:11-21.
10. Mitsumori, K., F. A. Talley, and M. R. Elwell. 1989. Epididymal interstitial (Leydig) cell tumors in B6C3F1 mice. Vet. Pathol. 26:65-69.
11. Stewart, H. L., M. K. Deringer, T. B. Dunn, and K. C. Snell. 1974. Malignant schwannomas of nerve roots, uterus, and epididymis in mice. J. Natl. Cancer Inst. 53:1749-1758.
12. Radovsky, A., K. Mitsumori, and R. E. Chapin. 1999. Male reproductive tract (testis and epididymis, accessory sex glands, and penis), p. 381-407. In R. R. Maronpot (ed.), Pathology of the mouse. Cache River Press, Vienna, Ill.
13. Ward, J. M., M. R. Anver, J. F. Mahler, and D. E. Devor-Henneman. 2000. Pathology of mice commonly used in genetic engineering (C57BL/6; 129; B6, 129; and FVB/N), p. 161-179. In J. M. Ward, J. F. Mahler, R. R. Maronpot, and J. P. Sundberg (ed.), Pathology of genetically engineered mice. Iowa State University Press, Ames, Iowa.
14. Haines, D. C., S. Chattopadhyay, and J. M. Ward. 2001. Pathology of aging B6;129 mice. Toxicol. Pathol. 29:653-661.
15. La Perle, K. M. D., S. M. Jhiang, and C. C. Capen. 2000. Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas. Am. J. Pathol. 157:671-677.
16. Butterworth, D. M. and D. L. Bisset. 1992. Cribriform intratubular epididymal change and adenomatous hyperplasia of the rete testis - a consequence of testicular atrophy? Histopathology 21:435-438.
17. Calder, C. J., N. Aluwihare, and C. T. Graham. 1993. Cribriform intra-tubular epididymal change. Histopathology 22:406.
18. Kuo, T. and L. G. Gomez. 1981. Monstrous epithelial cells in human epididymis and seminal vesicles. A pseudomalignant change. Am. J. Surg. Pathol. 5:483-490.
19. Oliva, E. and R. H. Young. 2000. Paratesticular tumor-like lesions. Semin. Diagn. Pathol. 17:340-358.
20. Shah, V. I., J. Y. Ro, M. B. Amin, S. Mullick, T. Nazeer, and A. G. Ayala. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am. J. Surg. Pathol. 22:990-996.
21. Sharp, S. C., M. A. Batt, and W. J. Lennington. 1994. Epididymal cribriform hyperplasia. A variant of normal epididymal histology. Arch. Pathol. Lab. Med. 118:1020-1022.
22. Abbott, D. P. 1993. Cribriform intra-tubular epididymal change and testicular atrophy. Histopathology 23:293.
23. Cappucci, D. T. and P. T. Cupps. 1966. Lesions of epididymides and testes from infertile bulls. J. Am. Vet. Med. Assoc. 148:1391-1395.
24. Elcock, L. H. and P. Schoning. 1984. Age-related changes in the cat testis and epididymis. Am. J. Vet. Res. 45:2380-2384.
25. Humphrey, J. D. and P. W. Ladds. 1975. A quantitative histological study of changes in the bovine testis and epididymis associated with age. Res. Vet. Sci. 19:135-141.
26. Mawdesley-Thomas, L. E. and D. Urwin. 1967. Epithelial hyperplasia of the epididymis in the beagle. Vet. Rec. 18:356-357.