Lac z histochemistry and immunohistochemistry reveal ephrin-B ligand expression in the inner ear

Journal of Histochemistry and Cytochemistry

Volumn 50, Issue 12, 2002, Pages 1641-1645

  Bianchi, Lynne M ^a   Dinsio, Kyl ^a   Davoli, Katherine ^a   Gale, Nicholas W ^a  

^a NONE

Author keywords

Cochlea; Ephrin B2; Ephrin B3; Transgenic mice; Vestibular

Indexed keywords

ANTIBODY; EPHRIN;

ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; COCHLEA; CONTROLLED STUDY; HISTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INNER EAR; LACTOSE OPERON; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VESTIBULE;

ANIMALIA; MUS MUSCULUS;

EID: 0036944770     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540205001208     Document Type: Article

References (9)

1. Bianchi LM, Conover JC, Fritzsch B, DeChiara T, Lindsay RM, Yancopoulos GD (1996) Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice. Development 122:1965-1973
2. Bianchi LM, Gale NW (1998) Distribution of Eph-related molecules in the developing and mature cochlea. Hear Res 117:161-172
3. Bianchi LM, Liu H (1999) Comparison of ephrin-A ligand and EphA receptor distribution in the developing inner ear. Anat Rec 254:127-134
4. Cowan C, Yokoyama N, Bianchi LM, Henkemeyer, M, Fritzsch B (2000) EphB2 tyrosine kinase activity guides axons at the midline and is necessary for normal vestibular function. Neuron 26:417-430
5. Gale NW, Baluk P, Pan L, Kwan M, Holash J, DeChiara TM, McDonald DM, et al. (2001) Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol 230:151-160
6. Gale NW, Holland SJ, Valenzuela DM, Flenniken AM, Pan L, Ryan TE, Henkemeyer M, et al. (1996) Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron 17:9-19
7. Kullander K, Croll SD, Zimmer M, Pan L, McClain J, Hughes V, Zabski S, et al. (2001) Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev 15:877-888
8. Matsunaga T, Greene MI, Davis JG (2000) Distinct expression patterns of Eph receptors and ephrins relate to the structural organization of the adult rat peripheral vestibular system. Eur J Neurosci 12:1599-1616
9. van Heuman WRA, Claxton C, Pickles JO (2000) Expression of EphA4 in the inner ears of the mouse and guinea pig. Hear Res 19:42-50