Novel mutant human fibronectin FIII9-10 domain pair with increased conformational stability and biological activity

Protein Engineering

Volumn 15, Issue 12, 2002, Pages 1021-1024

  Van der Walle, Christopher F ^a,b   Altroff, Harri ^a   Mardon, Helen J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

Cell adhesion; Conformational stability; Fibronectin; FIII domain; Proline substitution

Indexed keywords

AMINO ACID; FIBRONECTIN; HYBRID PROTEIN; LEUCINE; PROLINE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL ADHESION; HUMAN; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION;

EID: 0036941808     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/15.12.1021     Document Type: Article

References (20)

1. Altroff, H., van der Walle, C.F., Asselin, J., Fairless, R., Campbell I.D. and Mardon, H.J. (2001) J. Biol. Chem., 276, 38885-38892.
2. Aota, S., Nomizu, M. and Yamada, K.M. (1994) J. Biol. Chem., 269, 24756-24761.
3. Berman, H.M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T.N., Weissig, H., Shindyalov, I.N. and Bourne, P.E. (2000) Nucleic Acids Res., 28, 235-242.
4. Bowditch, R.D., Hariharan, M., Tominna, E.F., Smith, J.W., Yamada, K.M., Getzoff, E.D. and Ginsberg, M.H. (1994) J. Biol. Chem., 269, 10856-10863.
5. Copié, V., Tomita, Y., Akiyama, S.K., Aota, S., Yamada, K.M., Venable, R.M., Pastor, R.W., Krueger, S. and Torchia, D.A. (1998) J. Mol. Biol., 277, 663-682.
6. Dickinson, C.D., Veerapandian, B., Dai, X.P., Hamlin, R.C., Xuong, N.H., Ruoslahti, E. and Ely, K.R. (1994) J. Mol. Biol., 236, 1079-1092.
7. Grant, R.P., Spitzfaden, C., Altroff, H., Campbell, I.D. and Mardon, H.J. (1997) J. Biol. Chem., 272, 6159-6166.
8. Huber, A.H., Wang, Y.M., Bieber, A.J. and Bjorkman, P.J. (1994) Neuron, 12, 717-731.
9. Leahy, D.J., Aukhil, I. and Erickson, H.P. (1996) Cell, 84, 155-164.
10. Main, A.L., Harvey, T.S., Baron, M., Boyd, J. and Campbell, I.D. (1992) Cell, 71, 671-678.
11. Mardon, H.J. and Grant, K. (1994) FEBS Lett., 340, 197-201.
12. Pace, C.N. and Scholtz, J.M. (1997) In Creighton, T.E. (ed.), Protein Structure: a Practical Approach. IRL Press, Oxford, pp. 299-321.
13. Pearson, W.R. and Lipman, D.J. (1988) Proc. Natl Acad. Sci. USA, 85, 2444-2448.
14. Pierschbacher, M.D. and Ruoslahti, E. (1984) Nature, 309, 30-33.
15. Plaxco, K.W., Spitzfaden, C., Campbell, I.D. and Dobson, C.M. (1996) Proc. Natl Acad. Sci. USA, 93, 10703-10706.
16. Plaxco, K.W., Spitzfaden, C., Campbell, I.D. and Dobson, C.M. (1997) J. Mol. Biol., 270, 763-770.
17. Potts, J.R. and Campbell, I.D. (1994) Curr. Opin. Cell Biol., 6, 648-655.
18. Redick, S.D., Settles, D.L., Briscoe, G. and Erickson, H.P. (2000) J. Cell Biol., 149, 521-527.
19. Shirley, B.A., Stanssens, P., Steyaert, J. and Pace, C.N. (1989) J. Biol. Chem., 264, 11621-11625.
20. Spitzfaden, C., Grant, R.P., Mardon, H.J. and Campbell, I.D. (1997) J. Mol. Biol., 265, 565-579.