Simultaneous enantioseparation of a basic drug compound and its acidic intermediate by capillary electrophoresis

Journal of Separation Science

Volumn 25, Issue 15-17, 2002, Pages 1183-1189

  Zhou, Lili ^a   Thompson, Richard ^a   French, Mike ^a   Ellison, Dean ^a   Wyvratt, Jean ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Capillary electrophoresis; Cyclodextrins; Method development and validation; Pharmaceutical chiral compounds; Simultaneous enantioseparations

Indexed keywords

CAPILLARY TUBES; DRUG PRODUCTS; ELECTROLYTES; ELECTROPHORESIS; ISOMERS; PH EFFECTS; SYNTHESIS (CHEMICAL); THERMAL EFFECTS;

ENANTIOSEPARATION;

SEPARATION;

1 (2,2 DIFLUOROCYCLOPENTYL)PHENYLACETIC ACID; CYCLODEXTRIN DERIVATIVE; DRUG; N [1 (6 AMINOPYRIDIN 2 YLMETHYL)PIPERIDIN 4 YL] 2 (3,3 DIFLUOROCYCLOPENTYL) 2 HYDROXY 2 PHENYLACETAMIDE; UNCLASSIFIED DRUG;

ACCURACY; ACIDITY; ARTICLE; CAPILLARY ELECTROPHORESIS; CHIRALITY; CONTROLLED STUDY; DRUG MIXTURE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ISOMER; LINEAR SYSTEM; PH; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; TEMPERATURE; TIME; VALIDATION PROCESS;

EID: 0036929106     PISSN: 16159306     EISSN: None     Source Type: Journal    
DOI: 10.1002/1615-9314(20021101)25:15/17<1183::AID-JSSC1183>3.0.CO;2-S     Document Type: Article

References (21)

1. D.E. Drayer, Clin. Pharmacol. Ther. 1986, 40, 125-136.
2. FDA Policy Statement, Chirality 1992, 4, 338-340.
3. B. Chankvetadze, C. Blaschke, J. Chromatogr. A 2001, 906, 309-363.
4. C. Blaschke, B. Chankvetadze, J. Chromatogr. A 2000, 875, 3-25.
5. S. Fanali, J. Chromatogr. A 2000, 875, 89-122.
6. K. Otsuka, S. Terabe, J. Chromatogr. A 2000, 875, 163-178.
7. B. Chankvetadze, J. Chromatogr. A 1997, 792, 266-295.
8. L. Zhou, R. Thompson, S. Song, D. Ellison, J. Wyvratt, J. Pharm. Biomed. Anal. 2002, 27, 541-553.
9. B. Chankvetadze, K. Lomsadze, G. Blaschke, J. Sep. Sci. 2001, 24, 795-801.
10. M.R. Hadley, M. Decrete, G. Guillore, C. Rosini, M. Donnoli, S. Superchi, A.J. Hutt, J. Sep. Sci. 2001, 24, 766-776.
11. L. Zhou, B.D. Johnson, C. Miller, J.M. Wyvratt, J. Chromatogr. A 2000, 875, 389-401.
12. S.R. Gratz, A.M. Stalcup, Anal. Chem. 1998, 70, 5166-5171.
13. T. Mase, I. Houpis, I. Dorziotis, K. Emerson, T. Hoang, T. Iida, T. Itoh, K. Kamei, S. Kato, Y. Kato, M. Kawasaki, F. Lang, J. Lee, J. Lynch, P. Maligres, A. Molina, T. Nemoto, S. Okada, R. Reamer, J. Song, D. Tschaen, T. Wada, D. Wada, D. Zewe, R.P. Volante, P. Reider, K. Tomimoto, J. Org. Chem. 2001, 66, 6775-6786.
14. B. Williams, G. Vigh, J. Chromatogr. A 1997, 777, 295-309.
15. W. Friedl, J. Reijenga, E. Kenndler, J. Chromatogr. A 1995, 709, 163-170.
16. H. Cai, T. Nguyen, G. Vigh, Anal. Chem. 1998, 70, 580-589.
17. A.M. Stalcup, K.H. Gahm, Anal. Chem. 1996, 68, 1360-1368.
18. S. Fanali, C. Cartoni, Z. Aturki, J. Sep. Sci. 2001, 24, 789-794.
19. R. Kuhn, F. Erni, Anal. Chem. 1992, 64, 2815-2824.
20. B. Chankvetadze, G. Endresz, G. Blaschke, Electrophoresis 1994, 15, 804-815.
21. B. Chankvetadze, Capillary Electrophoresis in Chiral Analysis. Wiley & Sons, New York 1997, pp. 218-219.