Optimal designs for estimating the effective dose in developmental toxicity experiments

Risk Analysis

Volumn 22, Issue 6, 2002, Pages 1195-1205

  Krewski, Daniel ^a   Smythe, Robert ^b   Fung, Karen Y ^c  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OREGON STATE UNIVERSITY   (United States)

^c UNIVERSITY OF WINDSOR   (Canada)

Author keywords

Benchmark dose; Developmental toxicity; Dose response; Fetal death; Malformations; Optimal design; Weibull model

Indexed keywords

DESIGN; OPTIMIZATION; TOXICITY;

FETAL MALFORMATION; INTRA-LITTER CORELATIONS;

RISK ASSESSMENT;

TOXICITY;

ARTICLE; DOSE RESPONSE; FETUS DEATH; FETUS MALFORMATION; HUMAN; IMPLANT; MAXIMUM TOLERATED DOSE; MODEL; RISK ASSESSMENT; TERATOGENICITY; TOXICITY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL DEATH; MICE; MODELS, BIOLOGICAL; MODELS, STATISTICAL; PREGNANCY; RABBITS; RATS; RISK ASSESSMENT; TERATOGENS; TERATOLOGY;

EID: 0036924753     PISSN: 02724332     EISSN: None     Source Type: Journal    
DOI: 10.1111/1539-6924.00283     Document Type: Article

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