High prevalence of RET proto-oncogene activation (RET/PTC) in papillary thyroid carcinomas

European Journal of Endocrinology

Volumn 147, Issue 6, 2002, Pages 741-745

  Lam, King Yin ^c   Lo, Chung Yau ^a   Leung, Po Sing ^b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c JAMES COOK UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN RET;

ADULT; AGED; ANAPLASTIC CARCINOMA; ARTICLE; CHINESE; CHROMOSOME INVERSION; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE CLASSIFICATION; FEMALE; GENE ACTIVATION; GENE FREQUENCY; GENE REARRANGEMENT; GENETIC ANALYSIS; HONG KONG; HUMAN; INCIDENCE; MALE; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; THYROID FOLLICULAR CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA; CARCINOMA, PAPILLARY; CHILD; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; HONG KONG; HUMANS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; THYROID NEOPLASMS;

EID: 0036920380     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1470741     Document Type: Article

References (27)

1. Lorentz TG, Lau PW, Lo CY, Law WL, Wan KY & Lauder IJ. Multivariate analysis of risk factors influencing survival in 110 ethnic Chinese with papillary thyroid cancer. World Journal of Surgery 1994 18 547-550.
2. Pacini F, Elisei R, Romei C & Pinchera A. RET proto-oncogene mutations in thyroid carcinomas: clinical relevance. Journal of Endocrinological Investigation 2000 23 328-338.
3. Kjellman P, Learoyd DL, Messina M, Weber G, Hoog A, Wallin G et al. Expression of the RET proto-oncogene in papillary thyroid carcinoma and its correlation with clinical outcome. British Journal of Surgery 2001 88 557-563.
4. Lam AK, Montone KT, Nolan KA & Livolsi VA. Ret oncogene activation in papillary thyroid carcinoma: prevalence and implication on the histological parameters. Human Pathology 1998 29 565-568.
5. Hundahl SA, Cady B, Cunningham MP, Mazzaferri E, McKee RF, Rosai J et al. Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the United States during 1996. US and German Thyroid Cancer Study Group. An American College of Surgeons Commission on Cancer Patient Care Evaluation study. Cancer 2000 89 202-217.
6. Leung PS, Chan WP & Nobiling R. Regulated expression of pancreatic renin-angiotensin system in experimental pancreatitis. Molecular and Cellular Endocrinology 2000 166 121-128.
7. Viglietto G, Chiappetta G, Martinez-Tello FJ, Fukunaga FH, Tallini G, Rigopoulou D et al. RET/PTC oncogene activation is an early event in thyroid carcinogenesis. Oncogene 1995 11 1207-1210.
8. Nikiforov YE, Rowland JM, Bove KE, Monforte-Munoz H & Fagin JA. Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Research 1997 57 1690-1694.
9. Thomas GA, Bunnell H, Cook HA, Williams ED, Nerovnya A, Cherstvoy ED et al. High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. Journal of Clinical Endocrinology and Metabolism 1999 84 4232-4238.
10. Smida J, Salassidis K, Hieber L, Zitzelsberger H, Kellerer AM, Demidchik EP et al. Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus. International Journal of Cancer 1999 80 32-38.
11. Bounacer A, Wicker R, Caillou B, Cailleux AF, Sarasin A, Schlumberger M et al. High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation. Oncogene 1997 15 1263-1273.
12. Elisei R, Romei C, Vorontsova T, Cosci B, Veremeychik V, Kuchinskaya E et al. RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults. Journal of Clinical Endocrinology and Metabolism 2001 86 3211-3216.
13. Bongarzone I, Vigneri P, Mariani L, Collini F, Pilotti S & Pierotti MA. RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: correlation with clinicopathological features. Clinical Cancer Research 1998 4 223-228.
14. Learoyd DL, Messina M, Zedenius J, Guinea AI, Delbridge LW & Robinson BG. RET/PTC and RET tyrosine kinase expression in adult papillary thyroid carcinomas. Journal of Clinical Endocrinology and Metabolism 1998 83 3631-3635.
15. Mayr B, Potter E, Goretzki P, Ruschoff J, Dietmaier W, Hoang-Vu C et al. Expression of Ret/PTC1, -2, -3, -delta3 and -4 in German papillary thyroid carcinoma. British Journal of Cancer 1998 77 903-906.
16. Kitamura Y, Minobe K, Nakata T, Shimizu K, Tanaka S, Fujimori M et al. Ret/PTC3 is the most frequent form of gene rearrangement in papillary thyroid carcinomas in Japan. Journal of Human Genetics 1999 44 96-102.
17. Musholt TJ, Musholt PB, Khaladj N, Schulz D, Scheumann GF & Klempnauer J. Prognostic significance of RET and NTRK1 rearrangements in sporadic papillary thyroid carcinoma. Surgery 2000 128 984-993.
18. Sugg SL, Ezzat S, Rosen IB, Freeman JL & Asa SL. Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia. Journal of Clinical Endocrinology and Metabolism 1998 83 4116-4122.
19. Tallini G, Santoro M, Helie M, Carlomagno F, Salvatore G, Chiappetta G et al. RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes. Clinical Cancer Research 1998 4 287-294.
20. Fenton CL, Lukes Y, Nicholson D, Dinauer CA, Francis GL & Tuttle RM. The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults. Journal of Clinical Endocrinology and Metabolism 2000 85 1170-1175.
21. Chua EL, Wu WM, Tran KT, McCarthy SW, Lauer CS, Dubourdieu D et al. Prevalence and distribution of ret/ptc 1, 2, and 3 in papillary thyroid carcinoma in New Caledonia and Australia. Journal of Clinical Endocrinology and Metabolism 2000 85 2733-2739.
22. Park KY, Koh JM, Kim YI. Park HJ, Gong G, Hong SJ et al. Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population. Clinical Endocrinology 1998 49 317-323.
23. Chung JH, Hahm JR, Min YK, Lee MS, Lee MK, Kim KW et al. Detection of RET/PTC oncogene rearrangements in Korean papillary thyroid carcinomas. Thyroid 1999 9 1237-1243.
24. Motomura T, Nikiforov YE, Namba H, Ashizawa K, Nagataki S, Yamashita S et al. RET rearrangements in Japanese pediatric and adult papillary thyroid cancers. Thyroid 1998 8 485-489.
25. Lee CH, Hsu LS, Chi CW, Chen GD, Yang AH & Chen JY. High frequency of rearrangement of the RET protooncogene (RET/PTC) in Chinese papillary thyroid carcinomas. Journal of Clinical Endocrinology and Metabolism 1998 83 1629-1632.
26. La Perle KM, Jhiang SM & Capen CC. Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas. American Journal of Pathology 2000 157 671-677.
27. Lam KY, Lo CY, Chan KW & Wan KY. Insular and anaplastic carcinoma of the thyroid: a 45-year comparative study at a single institution and a review of the significance of p53 and p21. Annals of Surgery 2000 231 329-338.