Targeted inactivation of the mouse locus encoding coagulation factor XII-A: Hemostatic abnormalities in mutant mice and characterization of the coagulation deficit

Thrombosis and Haemostasis

Volumn 88, Issue 6, 2002, Pages 967-974

  Lauer, Peter ^a   Metzner, Hubert J ^a   Zettlmeißl, Gerd ^c   Li, Meng ^b   Smith, Austin G ^b   Lathe, Richard ^b   Dickneite, Gerhard ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c Chiron Behring GmbH & Co   (Germany)

Author keywords

Bleeding disorder; Factor XIII substitution; Fibrin dimerisation; Inactivation of FXIII gene; Thrombelastography

Indexed keywords

BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 13A; FIBRIN; FIBROGAMMIN P;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLEEDING TIME; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; CROSS LINKING; DIMERIZATION; DISEASE MARKER; ENZYME ACTIVITY; EXON; FEMALE; FERTILITY; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; GENE TARGETING; GENETIC ASSOCIATION; GENETIC CODE; GENETIC DISORDER; GENETIC STABILITY; HEMATOTHORAX; HEMOPERITONEUM; HEMOSTASIS; HETEROZYGOSITY; HOMOLOGOUS RECOMBINATION; HOMOZYGOSITY; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL ALLELE; PHENOTYPE; PLASMA; PRIORITY JOURNAL; REPRODUCTION; SUBSTITUTION REACTION; SURVIVAL RATE; THROMBOELASTOGRAPHY; WOUND HEALING IMPAIRMENT;

EID: 0036918577     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613342     Document Type: Article

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