Dysregulated expression of Bcl-xL in CD34+ cells isolated from patients with refractory anemia with excess of blasts during megakaryocytic differentiation

Haematologica

Volumn 87, Issue 12, 2002, Pages 1342-1343

  Martini, Maurizio ^a   Luongo, Myriam ^a   Teofili, Luciana ^a   Di Mario, Antonella ^a   Leone, Giuseppe ^a   Larocca, Luigi Maria ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Apoptosis; Bcl xL; Megakaryocytopoiesis; Myelodysplastic syndromes

Indexed keywords

CD34 ANTIGEN; PROTEIN BCL XL; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; AUTOCRINE EFFECT; BLAST CELL; CELL DIFFERENTIATION; CELL ISOLATION; HUMAN; HUMAN CELL; MEGAKARYOCYTE; MEGAKARYOPOIESIS; PROTEIN EXPRESSION; REFRACTORY ANEMIA; UPREGULATION;

ANEMIA, REFRACTORY, WITH EXCESS OF BLASTS; ANTIGENS, CD34; BCL-X PROTEIN; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HUMANS; MEGAKARYOCYTES; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0036911153     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Teofili L, Martini M, Di Mario A, Rutella S, Urbano R, Luongo M, et al. Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors. Blood 2001; 98:495-7.
2. +) progenitors but is absent from senescent megakaryocytes. Exp Hematol 2001; 29:728-35.
3. Kaluzhny Y, Yu G, Sun S, Toselli PA, Nieswandt B, Jackson CW, et al. Bcl-xL overexpression in megakaryocytes leads to impaired platelet fragmentation. Blood 2002; 100:1670-8.
4. Teofili L, Morosetti R, Martini M, Urbano R, Putzulu R, Rutella S, et al. Expression of cyclin-dependent kinase inhibitor p15(INK4B) during normal and leukemic myeloid differentiation. Exp Hematol 2000; 28:519-26.
5. NicAmhlaoibh R, Heenan M, Cleary I, Touhey S, O'Loughlin C, Daly C, et al. Altered expression of mRNAs for apoptosis-modulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdrl mRNA. Int J Cancer 1999; 82:368-76.