The potential of the essential fatty acid-deficient hairless rat as a psoriasis screening model for topical anti-proliferative drugs

Skin Pharmacology and Applied Skin Physiology

Volumn 15, Issue 6, 2002, Pages 401-413

  Jensen, Monika ^a   Groth, Lotte ^a,d   Hølmer, Gunhild ^b   Hansen, Harald S ^c   Fullerton, Ann ^a  

^a LEO PHARMA A S   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d NOVO NORDISK A S   (Denmark)

Author keywords

Calcipotriol; Dithranol; Essential fatty acid deficiency; Rat; Topical application

Indexed keywords

ANTIPSORIASIS AGENT; CALCIPOTRIOL; COAL TAR; DITHRANOL; DRUG VEHICLE; ESSENTIAL FATTY ACID; FATTY ACID; LINOLEIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; EPIDERMIS; ESSENTIAL FATTY ACID DEFICIENCY; FATTY ACID ANALYSIS; FEMALE; FLUID INTAKE; HISTOLOGY; LIPID DIET; MALE; NONHUMAN; OINTMENT; PRIORITY JOURNAL; PSORIASIS; RAT; SCREENING; SERUM; SKIN; SKIN MANIFESTATION; SKIN WATER LOSS; SKINFOLD THICKNESS; TREATMENT OUTCOME; WEIGHT;

ADMINISTRATION, TOPICAL; ANIMALS; ANTHRALIN; ANTI-INFLAMMATORY AGENTS; CALCITRIOL; CELL DIFFERENTIATION; CELL DIVISION; DERMATOLOGIC AGENTS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; EPIDERMIS; FATTY ACIDS, ESSENTIAL; FEMALE; GROWTH INHIBITORS; MALE; PSORIASIS; RATS; RATS, MUTANT STRAINS;

EID: 0036906876     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000066453     Document Type: Article

References (29)

1. Schön MP: Animal models of psoriasis. What can we learn from them? J Invest Dermatol 1999;112:405-410.
2. Burr GO, Burr M: A new deficiency disease produced by the rigid exclusion of fat from the diet. J Biol Chem 1929;82:345-367.
3. Holman RT: Essential fatty acid deficiency. Prog Chem Fats Other Lipids 1986;12:279-348.
4. Aaes-Jørgensen E: Essential fatty acids. Physiol Rev 1961;44:1-54.
5. Hansen HS: The essential nature of linoleic acid in mammals. Trends Biochem Sci 1986;11:263-265.
6. Wertz PW: Lipids and barrier function of the skin. Acta Derm Venereol Suppl (Stockh) 2000;208:7-11.
7. McCullough JL, Weinstein GD, Ziboh VA: Cell kinetics in psoriasis: The use of animal and human skin models; in Maibach H, Lowe NJ (eds): Models in Dermatology. Basel, Karger, 1985, pp 51-58.
8. Ghadially R, Reed JT, Elias PM: Stratum corneum structure and function correlates with phenotype in psoriasis. J Invest Dermatol 1996;107:558-564.
9. Bysted A, Lund P, Hølmer G: Influence of moderate amounts of trans fatty acid on the formation on polyunsaturated fatty acids. J Am Oil Chem Soc 1998;75:225-234.
10. Pinnagoda J, Tupker RA: Measurement of the transepidermal water loss; in Serup J, Jemec GBE (eds): Handbook of Non-Invasive Methods and the Skin. Boca Raton, CRC, 1995, pp 173-178.
11. Hansen HS, Jensen B: Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and α-linolenate. Biochim Biophys Acta 1985;834:357-363.
12. Wertz PW, Cho ES, Downing DT: Effect of essential fatty acid deficiency on the epidermal sphingolipids of the rat. Biochim Biophys Acta 1983;753:350-355.
13. Sinclair HM: Effects of deficiency of essential fatty acids in lower animals; in Sinclair HM (ed): Essential Fatty Acids. London, Academic, 1958, p 249.
14. Sinclair HM: Essential fatty acids and their relation to pyridoxine. Biochem Soc Symp 1952;9:80.
15. Holleran WM, Ginns EI, Menon GK, Grundmann J-U, Fartasch M, McKinney CE, Elias PM, Sidransky E: Consequences of β-glucocerebrosidase deficiency in epidermis. Ultrastucture and permeability barrier alterations in Gaucher disease. J Clin Invest 1994;93:1756-1764.
16. Melton JL, Wertz PW, Swartzendruber DC, Downing DT: Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. Biochim Biophys Acta 1987;921:191-197.
17. Smith SS, Neuringer M, Ojeda SR: Essential fatty acid deficiency delays the onset of puberty in the female rat. Endocrinology 1989;125:1650-1659.
18. Hartop PJ, Prottey C: Changes in transepidermal water loss and the composition of epidermal lecithin after applications of pure fatty acid triglycerides to the skin of essential fatty acid-deficient rats. Br J Dermatol 1976;95:255-264.
19. Mead JF, Slaton WH: Metabolism of essential fatty acids. 3. Isolation of 5,8,11-eicosatrienoic acid from fat deficient rats. J Biol Chem 1956;219:705.
20. Kingrey FAJ, Kellum RE: Essential fatty acid deficiency. Arch Dermatol 1965;91:272-279.
21. Brown WR, Burr GO: Some recent studies on fat deficiency. Proc Am Soc Biol Chem 1936;8:xvi.
22. Schaefer H, Redelmeier TE: Skin Barrier. Principles of Percutaneous Absorption. Basel, Karger, 1996.
23. Hartop PJ, Allenby CF, Prottey C: Comparison of barrier function and lipids in psoriasis and essential fatty acid-deficient rats. Clin Exp Dermatol 1978;3:259-267.
24. Murdoch D, Clissold P: Calcipotriol: A review of its pharmacological properties and therapeutic use in psoriasis vulgaris. Drugs 1992;43:415-429.
25. Solomon AE, Lowe NJ: Percutaneous absorption in experimental epidermal proliferation. Arch Dermatol 1978;114:1029-1030.
26. Verschoore M, Shroot B: Dithranol; in Dubertret L (ed): Psoriasis. Brescia, ISED, 1994, pp 112-115.
27. Fry L, McMinn RM: The action of chemotherapeutic agents on psoriatic epidermis. Br J Dermatol 1968; 80:373-383.
28. Sarkany I, Gaylarde PM: Effect of coal tar fractions on guinea-pig and human skin. Clin Exp Dermatol 1976;1:51-58.
29. Walter JF, Stoughton RB, DeQuoy PR: Suppression of epidermal proliferation by ultra violet light, coal tar and anthralin. Br J Dermatol 1978;99:89-96.