Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus: Prospective evaluation in a large cohort of Italian patients

Rheumatology

Volumn 41, Issue 12, 2002, Pages 1357-1366

  Gerli, R ^g   Caponi, L ^a   Tincani, A ^b   Scorza, R ^c   Sabbadini, M G ^d   Danieli, M G ^e   De Angelis, V ^f   Cesarotti, M ^g   Piccirilli, M ^g   Quartesan, R ^g   Moretti, P ^g   Cantoni, C ^g   Franceschini, F ^b   Cavazzana, I ^b   Origgi, L ^c   Vanoli, M ^c   Bozzolo, E ^d   Ferrario, L ^d   Padovani, A ^b   Gambini, O ^d   Vanzulli, L ^d   Croce, D ^d   Bombardieri, S ^a   more..

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^e UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^f ASL 2   (Italy)

^g UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Anti P antibodies; Anticardiolipin antibodies; Neuropsychiatric lupus; Systemic lupus erythematosus

Indexed keywords

ANTIMALARIAL AGENT; AUTOANTIBODY; CARDIOLIPIN ANTIBODY; CORTICOSTEROID; CYCLOPHOSPHAMIDE; EPITOPE; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENT; RIBOSOMAL P PROTEIN AUTOANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ANTIBODY DETECTION; ARTICLE; CLINICAL EXAMINATION; CLINICAL FEATURE; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; ITALY; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MEDICAL SPECIALIST; MENTAL DISEASE; NEUROPSYCHIATRY; NEUROPSYCHOLOGICAL TEST; PHOTOSENSITIVITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RASH; SENSITIVITY ANALYSIS; SEROLOGY; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; ANTIBODIES, ANTICARDIOLIPIN; AUTOANTIBODIES; BIOLOGICAL MARKERS; CHI-SQUARE DISTRIBUTION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LOGISTIC MODELS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; PROTOZOAN PROTEINS; RIBOSOMAL PROTEINS; STATISTICS, NONPARAMETRIC;

EID: 0036905617     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/41.12.1357     Document Type: Article

References (57)

1. Elkon KB, Parnassa AP, Foster CL. Lupus autoantibodies target ribosomal P proteins. J Exp Med 1985;162:459-71.
2. Francoeur A-M, Peebles CL, Heckman KJ, Lee JC, Tan EM. Identification of ribosomal P protein autoantigens. J Immunol 1985;135:2378-84.
3. Elkon KB, Skelly S, Parnassa A et al. Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus. Proc Natl Acad Sci USA 1986;83:7419-23.
4. Sato T, Uchiumi T, Ozawa T et al. Autoantibodies against ribosomal proteins found with high frequency in patients with systemic lupus erythematosus with active disease. J Rheumatol 1991;18:1681-4.
5. Nojima I, Minota S, Yamada A, Takaku F, Aotsuka S, Yokohari R. Correlation of antibodies to ribosomal P protein with psychosis in patients with systemic lupus erythematosus. Ann Rheum Dis 1992;51:1053-5.
6. Teh LS, Isenberg DA. Antiribosomal P protein antibodies in systemic lupus erythematosus. A reappraisal. Arthritis Rheum 1994;37:307-15.
7. Arnett FC, Reveille JD, Moutsopoulos HM, Georgescu L, Elkon KB. Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic association. Arthritis Rheum 1996;39:1833-9.
8. Teh LS, Doherty DG, Williams BD. HLA-DRB genes and antiribosomal P antibodies in systemic lupus erythematosus. Br J Rheumatol 1994;33:1125-6.
9. Koren E, Schnitz, Reichlin M. Concomitant development of chronic active hepatitis and antibodies to ribosomal P proteins in a patient with systemic lupus erythematosus. Arthritis Rheum 1993;36:1325-8.
10. Hulsey M, Goldstein R, Scully L, Surbeck W, Reichlin M. Anti-ribosomal P antibodies in systemic lupus erythematosus: a case-control study correlating hepatic and renal disease. Clin Immunol Immunopathol 1995;74:252-6.
11. Arnett FC, Reichlin M. Lupus hepatitis: an underrecognized disease feature associated with autoantibodies to ribosomal P. Am J Med 1995;99:465-72.
12. Martin AL, Reichlin M. Fluctuations of antibody to ribosomal P proteins correlate with appearance and remission of nephritis in SLE. Lupus 1996;5:22-9.
13. Chindalore V, Neas B, Reichlin M. The association between anti-ribosomal P antibodies and active nephritis in systemic lupus erythematosus. Clin Immunol Immunopathol 1998;87:292-6.
14. Yoshio T, Masuyama J-I, Minota S et al. A close temporal relationship of liver disease to antiribosomal PO protein antibodies and central nervous system disease in patients with systemic lupus erythematosus. J Rheumatol 1998; 25:681-8.
15. Bonfa E, Elkon KB. Clinical and serological associations of the antiribosomal P protein antibody. Arthritis Rheum 1986;29:981-5.
16. Bonfa E, Golombek SJ, Kaufman LD et al. Association between lupus psychosis and anti-ribosomal P-protein antibodies. N Engl J Med 1987;317:265-71.
17. Derksen RHWM, van Dam AP, Gmelig Meyling FHJ, Bijlsma JWJ, Smeenk RJT. A prospective study of antiribosomal P proteins in two cases of familial lupus and recurrent psychosis. Ann Rheum Dis 1990; 49:779-82.
18. Schneebaum AB, Singleton JD, Sterling GW et al. Association of psychiatric manifestation with antibodies to ribosomal P proteins in systemic lupus erythematosus. Am J Med 1991;90:54-62.
19. Van Dam A, Nossent H, de Jong J et al. Diagnostic value of antibodies against ribosomal phosphoproteins. A cross sectional and longitudinal study. J Rheumatol 1991; 18:1026-34.
20. Teh LS, Hay EM, Amos N et al. Anti-P antibodies are associated with psychiatric and focal cerebral disorders in patients with systemic lupus erythematosus. Br J Rheumatol 1993;32:287-90.
21. Yoshio T, Masuyama J-I, Ikeda M et al. Quantification of antiribosomal PO protein antibodies by ELISA with recombinant PO fusion protein and their association with central nervous system disease in systemic lupus erythematosus. J Rheumatol 1995;22:1681-7.
22. West SG, Emlen W, Wener MH, Kotzin BL. Neuropsychiatric lupus erythematosus: a 10-year prospective study on the value of diagnostic tests. Am J Med 1995; 99:153-62.
23. Watanabe T, Sato T, Uchiumi T, Arakawa M. Neuropsychiatric manifestation in patients with systemic lupus erythematosus: diagnostic and predictive value of longitudinal examination of anti-ribosomal P antibody. Lupus 1996;5:178-83.
24. Press J, Palayew K, Laxer RM et al. Antiribosomal P antibodies in pediatric patients with systemic lupus erythematosus and psychosis. Arthritis Rheum 1996; 39:671-6.
25. Isshi K, Hirohata S. Association of antiribosomal P protein antibodies with neuropsychiatric systemic lupus erythematosus. Arthritis Rheum 1996;39:1483-90.
26. Tzioufas AG, Tzortzakis NG, Panou-Pomonis E et al. The clinical relevance of antibodies to ribosomal-P common epitope in two targeted systemic lupus erythematosus populations: a large cohort of consecutive patients and patients with active central nervous system disease. Ann Rheum Dis 2000;59:99-104.
27. Iverson GL. Are antibodies to ribosomal P proteins a clinically useful predictor of neuropsychiatric manifestations in patients with systemic lupus erythematosus? Lupus 1996;5:634-5.
28. Caponi L, Pegoraro S, Di Bartolo V, Rovero P, Revoltella R, Bombardieri S. Autoantibodies directed against ribosomal P proteins: use of a multiple antigen peptide as the coating agent in ELISA. J Immunol Methods 1995;179:193-202.
29. Yoshio T, Masuyama J-I, Minota S et al. Correlation of serum IgG antibodies to recombinant P0 fusion protein with IgG antibodies to carboxyl-terminal 22 synthetic peptides and carboxyl-terminal 22 amino acid-deleted recombinant P0 fusion protein in patients with systemic lupus erythematosus. Arthritis Rheum 1997; 40:1364-5.
30. Hirohata S, Isshi K, Toyoshima S. The role of carrier protein in the sensitivity of enzyme-linked immunosorbent assay for antiribosomal P protein antibodies: further comment on the article by Yoshio et al. Arthritis Rheum 1999;42:593-4.
31. Rayno K, Reichlin M. Evaluation of assays for the detection of autoantibodies to the ribosomal P proteins. Clin Immunol 2000;95:99-103.
32. Ghirardello A, Doria A, Zampieri S, Gerli R, Rapizzi E, Gambari PF. Anti-ribosomal P protein antibodies detected by immunoblotting in patients with connective tissue diseases: their specificity for SLE and association with IgG anticardiolipin antibodies. Ann Rheum Dis 2000;59:975-81.
33. Sibley JT, Olszynski WP, Decoteau WE, Sundaram MB. The incidence and prognosis of central nervous system disease in systemic lupus erythematosus. J Rheumatol 1992; 19:47-52.
34. West SG. Neuropsychiatric lupus. Rheum Dis Clin North Am 1994;20:129-58.
35. Mitchell I, Webb M, Hughes R, Maisey M, Cameron JS. Cerebral lupus. Lancet 1994;343:579-82.
36. Rood MJ, Breedveld FC, Huizinga TWJ. The accuracy of diagnosing neuropsychiatric systemic lupus erythematosus in a series of 49 hospitalized patients. Clin Exp Rheumatol 1999;17:55-61.
37. Khoshbin S, Glanz BI, Schur PH. Neuropsychiatric syndromes in systemic lupus erythematosus: a new look. Clin Exp Rheumatol 1999;17:395-8.
38. ACR ad hoc Committee on Neuropsychiatric Lupus Nomenclature. The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum 1999;42:599-608.
39. Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
40. Hochberg MC. Updating the Americam College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40:1725.
41. Vitali C, Bencivelli W, Isenberg DA et al. Disease activity in systemic lupus erythematosus: report of the Consensus Study Group of the European Workshop for Rheumatology Research. II. Identification of the variables indicative of disease activity and their use in the development of an activity score. Clin Exp Rheumatol 1992;10:541-7.
42. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th edn. Washington (DC): American Psychiatric Association, 1994.
43. Sabbadini MG, Manfredi AA, Bozzolo E et al. Central nervous system involvement in systemic lupus erythematosus patients without overt neuropsychiatric manifestations. Lupus 1999;8:11-9.
44. Bunn CC, Gharavi AE, Hughes GRV. Antibodies to extractable nuclear antigens in 173 patients with DNA-binding positive SLE: an association between antibodies to ribonucleoprotein and Sm antigens observed by counterimmunoelectrophoresis. J Clin Lab Immunol 1982; 8:13-7.
45. Harris EN. Special report. The second international anti-cardiolipin standardization workshop/the Kingstone Anti-Phospholipid Antibody Study (KAPS) group. Am J Clin Pathol 1990;94:476-84.
46. Reichlin M, Faulkner Broyles T, Hubscher O et al. Prevalence of autoantibodies to ribosomal P proteins in juvenile-onset systemic lupus erythematosus compared with the adult disease. Arthritis Rheum 1999; 42:69-75.
47. Elkon KB, Bonfa E, Weissbach H, Brot N. Antiribosomal antibodies in SLE, infection, and following deliberate immunization. Adv Exp Med Biol 1994;347:81-92.
48. Reichlin M, Wolfson-Reichlin M. Evidence for the participation of anti-ribosomal P antibodies in lupus nephritis. Arthritis Rheum 1999;42:2728-9.
49. Caponi L, Pegoraro S, Di Bartolo V, Rovero P, Revoltella R, Bombardieri S. Anti-P protein antibodies in systemic lupus erythematosus: correlations with clinical and serological data. Clin Rheumatol 1995;14:239.
50. Koren E, Koscec M, Reichlin M, Fugate R, Reichlin M. Possible role of autoantibodies to ribosomal P proteins in development of liver disease in patients with systemic lupus erythematosus. Arthritis Rheum 1993;S36:72.
51. Koscec M, Koren E, Wolfson-Reichlin M et al. Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture. J Immunol 1997;159:2033-41.
52. Caponi L, Bombardieri S, Mighorini P. Anti-ribosomal antibodies bind the Sm proteins D and B/B′. Clin Exp Immunol 1998; 112:139-43.
53. Caponi L. The cross-reactivity of autoantibodies in connective tissue diseases. Clin Exp Rheumatol 1996; 14:425-31.
54. Navarro E, Palau J. Anti-Sm sera are misdetected by counterimmunoelectrophoresis. A critical analysis of CIE and western blotting on the detection of human antinuclear antibodies. J Autoimmun 1991;4:213-22.
55. Hanly JG, Walsh NM, Fisk JD et al. Cognitive impairment and autoantibodies in systemic lupus erythematosus. Br J Rheumatol 1993;32:291-6.
56. Isshi K, Hirohata. S. Differential roles of the antiribosomal P antibody and anti-neuronal antibody in the pathogenesis of central nervous system involvement in systemic lupus erythematosus. Arthritis Rheum 1998; 41:1819-27.
57. Vitali C, Bencivelli DA, Isenberg DA et al. Disease activity in systemic lupus erythematosus: report of the Consensus Study Group of the European Workshop for Rheumatology Research. I. A descriptive analysis of 704 European lupus patients. Clin Exp Rheumatol 1992; 10:527-39.