No association between high-altitude tolerance and the ACE I/D gene polymorphism

Medicine and Science in Sports and Exercise

Volumn 34, Issue 12, 2002, Pages 1928-1933

  Dehnert, Christoph ^a,b,c,d,e   Weymann, Jörn ^a,b,c,d,e   Montgomery, Hugh E ^a,b,c,d,e   Woods, David ^a,b,c,d,e   Maggiorini, Marco ^a,b,c,d,e   Scherrer, Urs ^a,b,c,d,e   Simon, J ^a,b,c,d,e   Gibbs, R ^a,b,c,d,e   Bärtsch, Peter ^a,b,c,d,e  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e Centre Hospitalier   (Switzerland)

Author keywords

Fluid retention; Hypoxia; Hypoxic pulmonary vasoconstriction; Pulmonary artery pressure; Renin angiotensin aldosterone system

Indexed keywords

ACETAZOLAMIDE; ALDOSTERONE; ANGIOTENSIN; DIPEPTIDYL CARBOXYPEPTIDASE; GLUCOCORTICOID; NIFEDIPINE;

ADULT; ALLELE; ALTITUDE; ALTITUDE DISEASE; ANAMNESIS; ARTICLE; BASE PAIRING; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA POLYMORPHISM; ENVIRONMENT; FLUID RETENTION; GENE DELETION; GENE INSERTION; GENOTYPE; HUMAN; HYPOTHESIS; LUNG EDEMA; MAJOR CLINICAL STUDY; MOUNTAINEERING; PATHOPHYSIOLOGY; PREVALENCE; PULMONARY HYPERTENSION; QUESTIONNAIRE; SCORING SYSTEM; STATISTICAL ANALYSIS; SYMPTOM; VASOCONSTRICTION;

EID: 0036898755     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005768-200212000-00011     Document Type: Article

References (32)

1. Bärtsch, P., N. Pfluger, M. Audetat, et al. Effects of slow ascent to 4559 m on fluid homeostasis. Aviat. Space Environ. Med. 62:105-110, 1991.
2. Bärtsch, P. High altitude pulmonary edema. Respiration 64:435-443, 1997.
3. Bärtsch, P., M. Maggiorini, M. Ritter, C. Noti, P. Vock, and O. Oelz. Prevention of high-altitude pulmonary edema by nifedipine. N. Engl. J. Med. 325:1284-1289, 1991.
4. Bärtsch, P., M. Maggiorini, W. Schobersberger, et al. Enhanced exercise-induced rise of aldosterone and vasopressin preceding mountain sickness. J. Appl. Physiol. 71:136-143, 1991.
5. Bärtsch, P., and R. Roach. Acute mountain sickness and high-altitude cerebral edema. In: High Altitude: An Exploration of Human Adaptation, T. F. Hornbein and R. B. Schoene (Eds.). New York: Marcel Dekker, Inc., 2001, pp. 731-776.
6. Bärtsch, P., S. Shaw, M. Franciolli, M. P. Gnadinger, and P. Weidmann. Atrial natriuretic peptide in acute mountain sickness. J. Appl. Physiol. 65:1929-1937, 1988.
7. Bärtsch, P., S. Shaw, P. Weidmann, W. Hildebrandt, T. Bucler, and J. Biollaz. Fluid retention in acute mountain sickness: Cause or consequence? In: Progress in Mountain Medicine and High Altitude Physiology, H. Ohno, T. Kobayashi, S. Masuyama, and M. Nakashima (Eds.). Matsumoto: Press Committee of the 3rd World Congress on Mountain Medicine and High Altitude Physiology, 1998, pp. 234-239.
8. Bolla, M. K., L. Haddad, S. E. Humphries, A. F. Winder, and I. N. Day. High-throughput method for determination of apolipoprotein E genotypes with use of restriction digestion analysis by microplate array diagonal gel electrophoresis. Clin. Chem. 41:1599-1604, 1995.
9. Brown, N. J., C. Blais Jr., S. K. Gandhi, and A. Adam. Ace insertion/deletion genotype affects bradykinin metabolism. J. Cardiovasc. Pharmacol. 32:373-377, 1998.
10. Cargill, R. I., and B. J. Lipworth. Lisinopril attenuates acute hypoxic pulmonary vasoconstriction in humans. Chest 109:424-429, 1996.
11. Hackett, P. H., D. Rennie, S. E. Hofmeister, R. F. Grover, E. B. Grover, and J. T. Reeves. Fluid retention and relative hypoventilation in acute mountain sickness. Respiration 43:321-329, 1982.
12. Hackett, P. H., and R. C. Roach. High-altitude illness. N. Engl. J. Med. 345:107-114, 2001.
13. Hohenhaus, E., F. Niroomand, S. Goerre, P. Vock, O. Oelz, and P. Bärtsch. Nifedipine does not prevent acute mountain sickness. Am. J. Respir. Crit. Care Med. 150:857-860, 1994.
14. Hultgren, H. N., R. F. Grover, and L. H. Hartley. Abnormal circulatory responses to high altitude in subjects with a previous history of high-altitude pulmonary edema. Circulation 44:759-770, 1971.
15. Kleger, G. R., P. Bärtsch, P. Vock, B. Heilig, L. J. Roberts, and P. E. Ballmer. Evidence against an increase in capillary permeability in subjects exposed to high altitude. J. Appl. Physiol. 81:1917-1923, 1996.
16. Maggiorini, M., C. Melot, S. Pierre, et al. High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation 103:2078-2083, 2001.
17. Maggiorini, M., A. Muller, D. Hofstetter, P. Bärtsch, and O. Oelz. Assessment of acute mountain sickness by different score protocols in the Swiss Alps. Aviat. Space Environ. Med. 69:1186-1192, 1998.
18. Milledge, J. S., J. M. Beeley, S. McArthur, and A. H. Morice. Atrial natriuretic peptide, altitude and acute mountain sickness. Clin. Sci. (Colch.) 77:509-514, 1989.
19. Montgomery, H. E., P. Clarkson, C. M. Dollery, et al. Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation 96:741-747, 1997.
20. Montgomery, H. E., R. Marshall, H. Hemingway, et al. Human gene for physical performance. Nature 393:221-222, 1998.
21. Morrell, N. W., E. N. Atochina, K. G. Morris, S. M. Danilov, and K. R. Stenmark. Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. J. Clin. Invest. 96:1823-1833, 1995.
22. Morrell, N. W., K. G. Morris, and K. R. Stenmark. Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension. Am. J. Physiol. 269:H1186-H1194, 1995.
23. Morrell, N. W., A. S. Sarybaev, A. Alikhan, M. M. Mirrakhimov, and A. A. Aldashev. ACE genotype and risk of high altitude pulmonary hypertension in Kyrghyz highlanders. Lancet 353:814, 1999.
24. O'Dell, S. D., S. E. Humphries, and I. N. Day. Rapid methods for population-scale analysis for gene polymorphisms: The ACE gene as an example. Br. Heart J. 73:368-371, 1995.
25. Oelz, O., M. Maggiorini, M. Ritter, et al. Nifedipine for high altitude pulmonary oedema. Lancet 2:1241-1244, 1989.
26. Prasad, A., S. Narayanan, S. Husain, et al. Insertion-deletion polymorphism of the ACE gene modulates reversibility of endothelial dysfunction with ACE inhibition. Circulation 102:35-41, 2000.
27. Richalet, J. P., A. Keromes, and B. Dersch. Caracteristiques physiologiques des alpinistes de haute altitude. Sci. Sports 3:89-108, 1988.
28. Rigat, B., C. Hubert, F. Alhenc-Gelas, F. Cambien, P. Corvol, and F. Soubrier. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 86:1343-1346, 1990.
29. Sampson, J. B., A. Cymerman, R. L. Burse, J. T. Maher, and P. B. Rock. Procedures for the measurement of acute mountain sickness. Aviat. Space Environ. Med. 54:1063-1073, 1983.
30. Scherrer, U., L. Vollenweider, A. Delabays, et al. Inhaled nitric oxide for high-altitude pulmonary edema. N. Engl. J. Med. 334:624-629, 1996.
31. Vock, P., C. Fretz, M. Franciolli, and P. Bärtsch. High-altitude pulmonary edema: Findings at high-altitude chest radiography and physical examination. Radiology 170:661-666, 1989.
32. Zhu, X., N. Bouzekri, L. Southam, et al. Linkage and association analysis of angiotensin I-converting enzyme (ACE)-gene polymorphisms with ACE concentration and blood pressure. Am. J. Hum. Genet. 68:1139-1148, 2001.