ACE genotype and risk of high altitude pulmonary hypertension in Kyrghyz highlanders

Lancet

Volumn 353, Issue 9155, 1999, Pages 814-

  Morrell, Nicholas W ^a   Sarybaev, Akpai S ^b   Alikhan, Amjad ^b   Mirrakhimov, Mirsaid M ^b   Aldashev, Almas A ^b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b National Center of Cardiology and Internal Medicine   (Kyrgyzstan)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ALTITUDE; ARTICLE; ENZYME BLOOD LEVEL; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HEART CATHETERIZATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; LUNG HEMODYNAMICS; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RISK FACTOR; STATISTICAL ANALYSIS; TISSUE LEVEL;

EID: 0344820775     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(99)00206-8     Document Type: Article

References (5)

1. Mirrakhimov M, Winslow R. The cardiovascular system at high altitude. In: Fregley, M, Blatteal C, eds. Environmental physiology, Oxford: Oxford University Press, 1996, Pp 1241-1258.
2. Weir EK, Tucker A, Reeves JT, Will DH, Grover RF. The genetic factor influencing pulmonary hypertension in cattle at high altitude. Cardiovasc Res 1974; 8: 745-49.
3. Wilkins MR, Zhao L, Al-Tubuly R. The regulation of pulmonary vascular tone. Br J Clin Pharmacol 1996; 42: 127-31.
4. Morrell NW, Atochina EN, Morris KG, Danilov SG, Stenmark KR. Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. J Clin Invest 1995; 96: 1823-33.
5. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the antagonist-1-converting enzyme accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-46.