Acitretin-associated thrombotic stroke

Annals of Pharmacotherapy

Volumn 36, Issue 12, 2002, Pages 1879-1882

  Royer, Bernard ^b   Ziegler, François ^c   Muret, Patrice ^c   Davani, Siamak ^c   Kantelip, Jean Pierre ^c  

^a Belfort Hospital   (France)

^b UNIVERSITY HOSPITAL JEAN MINJOZ   (France)

^c NONE

Author keywords

Acitretin; Adverse reactions; Stroke; Thrombosis

Indexed keywords

ANALGESIC AGENT; ANTICOAGULANT AGENT; ANTIEMETIC AGENT; DEXTROPROPOXYPHENE; DOMPERIDONE; DRUG DERIVATIVE; ETRETIN; FLUINDIONE; HEPARIN; KERATOLYTIC AGENT; METOCLOPRAMIDE; PHENINDIONE; MORPHINE; N ACETYLLEUCINE; OMEPRAZOLE; PARACETAMOL; UNCLASSIFIED DRUG;

ARTICLE; CASE REPORT; CEREBROVASCULAR ACCIDENT; CHEMICALLY INDUCED DISORDER; FEMALE; HEADACHE; HUMAN; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; THROMBOSIS; ADULT; ANTICOAGULANT THERAPY; CLINICAL FEATURE; DISEASE DURATION; MAGNETIC RESONANCE ANGIOGRAPHY; NAUSEA; OCCLUSIVE CEREBROVASCULAR DISEASE; PHYSIOTHERAPY; PRESCRIPTION; PRIORITY JOURNAL; PSORIASIS; RECUMBENCY; STANDING; TREATMENT OUTCOME; VERTEBRAL ARTERY; VERTIGO; VOMITING;

ACITRETIN; ANALGESICS; ANTICOAGULANTS; ANTIEMETICS; CEREBROVASCULAR ACCIDENT; DOMPERIDONE; FEMALE; HEADACHE; HEPARIN; HUMANS; KERATOLYTIC AGENTS; MAGNETIC RESONANCE IMAGING; METOCLOPRAMIDE; MIDDLE AGED; PHENINDIONE; PROPOXYPHENE; THROMBOSIS;

EID: 0036896844     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1C090     Document Type: Article

References (26)

1. Orfanos CE, Zouboulis CC, Almond-Roesler B, Geilen CC. Current use and future potential role of retinoids in dermatology. Drugs 1997;53:358-88.
2. Pilkington T, Brogden RN. Acitretin. A review of its pharmacology and therapeutic use. Drugs 1992;43:597-627.
3. Rubattu S, Giliberti R, Volpe M. Etiology and pathophysiology of stroke as a complex trait. Am J Hypertens 2000;13:1139-48.
4. Mohr JP, Albers GW, Amarenco P, Babikian VL, Biller J, Brey RL, et al. American Heart Association Prevention Conference. IV. Prevention and Rehabilitation of Stroke. Etiology of stroke. Stroke 1997;28:1501-6.
5. Sacco RL, Benjamin EJ, Broderick JP, Dyken M, Easton JD, Feinberg WM, et al. American Heart Association Prevention Conference. IV. Prevention and Rehabilitation of Stroke. Risk factors. Stroke 1997;28:1507-17.
6. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45.
7. Tanew A, Guggenbichler A, Honigsmann H, Geiger JM, Fritsch P. Photochemotherapy for severe psoriasis without or in combination with acitretin: A randomized, double-blind comparison study. J Am Acad Dermatol 1991;25:682-4.
8. Ledo A, Martin M, Geiger JM, Marron JM. Acitretin (Ro 10-1670) in the treatment of severe psoriasis. A randomized double-blind parallel study comparing acitretin and etretinate. Int J Dermatol 1988;27:656-60.
9. Gollnick H, Bauer R, Brindley C, Orfanos CE, Plewig G, Wokalek H, et al. Acitretin versus etretinate in psoriasis. Clinical and pharmacokinetic results of a German multicenter study. J Am Acad Dermatol 1988;19:458-68.
10. Saurat JH, Geiger JM, Amblard P, Beani JC, Boulanger A, Claudy A, et al. Randomized double-blind multicenter study comparing acitretin-PUVA, etretinate-PUVA and placebo-PUVA in the treatment of severe psoriasis. Dermatologica 1988;177:218-24.
11. Kragballe K, Jansen CT, Geiger JM, Bjerke JR, Falk ES, Gip L, et al. A double-blind comparison of acitretin and etretinate in the treatment of severe psoriasis. Results of a Nordic multicentre study. Acta Derm Venereol 1989;69:35-40.
12. Arboix A, Bechich S, Oliveres M, Garcia-Eroles L, Massons J, Targa C. Ischemic stroke of unusual cause: Clinical features, etiology and outcome. Eur J Neurol 2001;8:133-9.
13. Randolph TR. Acute promyelocytic leukemia (AML-M3) - Part 1: Pathophysiology, clinical diagnosis, and differentiation therapy. Clin Lab Sci 2000;13:98-105.
14. Lopez-Pedrera C, Dobado-Berrios PM, Ros R, Torres A, Garcia-Navarro S, Jardi M, et al. Signal transduction pathways underlying the expression of tissue factor and thrombomodulin in promyelocytic cells induced to differentiate by retinoid acid and dibutyryl cAMP. Thromb Haemost 2001;85:1031-6.
15. Fontana JA, Reppucci A, Durham JP, Miranda D. Correlation between the induction of leukemic cell differentiation by various retinoids and modulation of protein kinases. Cancer Res 1986;46:2468-73.
16. Ishii H, Horie S, Kizaki K, Kazama M. Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor. Blood 1992;80:2556-62.
17. Falanga A, Consonni R, Marchetti M, Locatelli G, Garattini E, Passerini CG, et al. Cancer procoagulant and tissue factor are differently modulated by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood 1998;92:143-51.
18. Conese M, Montemurro P, Fumarulo R, Giordano D, Riccardi S, Colucci M, et al. Inhibitory effect of retinoids on the generation of procoagulant activity by blood mononuclear phagocytes. Thromb Haemost 1991;66:662-5.
19. Barstad RM, Hamers MJ, Stephens RW, Sakariassen KS. Retinoic acid reduces induction of monocyte tissue factor and tissue factor/factor VIIa-dependent arterial thrombus formation. Blood 1995;86:212-8.
20. Wang ZY, Chen Z, Huang W, Li XS, Lu JX, Huang LA, et al. Problems existing in differentiation therapy of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA). Blood Cells 1993;19:633-41.
21. de Lacerda JF, do Carmo JA, Guerra ML, Geraldes J, de Lacerda JM. Multiple thrombosis in acute promyelocytic leukaemia after tretinoin. Lancet 1993;342:114-5.
22. Kocak U, Gursel T, Ozturk G, Kantarci S. Thrombosis during all-trans-retinoic acid therapy in a child with acute promyelocytic leukemia and factor VQ 506 mutation. Pediatr Hematol Oncol 2000;17:177-80.
23. Hartmann D, Mosberg H, Weber W. Lack of effect of acitretin on the hypothrombinemic action of phenprocoumon in healthy volunteers. Dermatologica 1989;178:33-6.
24. Bounameaux H, Reber G, Bounameaux Y. Acute effects of retinoids on fibrinolysis before and after venous occlusion in healthy humans. Thromb Res 1988;50:175-9.
25. Barbui T, Finazzi G, Falanga A. The impact of all-trans-retinoic acid on the coagulopathy of acute promyelocytic leukemia. Blood 1998;91:3093-102.
26. Roos TC, Merk HF. Important drug interactions in dermatology. Drugs 2000:59:181-92.