Signal transduction pathways underlying the expression of tissue factor and thrombomodulin in promyelocytic cells induced to differentiate by retinoid acid and dibutyryl cAMP

Thrombosis and Haemostasis

Volumn 85, Issue 6, 2001, Pages 1031-1036

  Lopez Pedrera C ^a   Dobado Berrios, P M ^a   Ros, R ^a   Torres, A ^a   Garcia Navarro S ^a   Jardi M ^a   Felez J ^a   Velasco, F ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

Cell differentiation; Promyelocytic cells; Signal transduction; Thrombomodulin; Tissue factor

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; BUCLADESINE; CD11B ANTIGEN; CELL RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; INOSITOL; INOSITOL PHOSPHATE; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; PHLORETIN; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE INHIBITOR; RETINOIC ACID; RETINOID; THROMBOMODULIN; THROMBOPLASTIN;

ANTIGEN EXPRESSION; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MODULATION; PRIORITY JOURNAL; PROMYELOCYTE; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0034976940     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615959     Document Type: Article

References (33)

1. Acute promyelocytic leukaemia: Biology and treatment
2. Reassessing the hemostatic disorder associated with acute promyelocytic leukaemia
3. All-trans-retinoic acid up-regulates thrombomodulin and down-regulates tissue factor expression in acute promyelocytic leukaemia cells: Distinct expression of thrombomodulin and tissue factor in human leukaemic cells
4. Tissue factor (TF) and urokinase plasminogen activator receptor (uPAR) and bleeding complications in leukemic patients
5. Cancer procoagulant in the human promyelocytic cell line NB4 and its modulation by retinoic acid
6. Loss of blast cell procoagulant activity and improvement of hemostatic variables in patients with acute promyelocytic leukemia on all-trans-retinoic acid
7. The HL-60 promyelocytic leukemia cell line: Proliferation, differentiation, and cellular oncogen expression
8. Retinoic acid signal transduction pathways
9. Intracellular concentration of inositol, glycerophosphoinositol and inositol pentakis-phosphate increase during haemopoietic cell differentiation
10. Protein kinase C and its substrates
11. Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblast treated with 1,25-dihy-droxyvitamin D3
12. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)
13. Cyclic AMP-dependent and independent protein kinases and protein phosphorylation in human promyelocytic leukemia (HL-60) cells induced to differentiate by retinoic acid
14. Regulation of protein phosphotyrosine content by changes in tyrosine kinase and protein phosphotyrosine phosphatase activities during induced granulocytic and monocytic differentiation of HL-60 leukemia cells
15. Sequential protein kinase reactions controlling cell growth and differentiation
16. Activation of β-isozyme of protein kinase C (PKCβ) is necessary and sufficient for phorbol ester-induced differentiation of HL-60 promyelocytes
17. Protein kinase inhibitors exert stage specific and inducer dependent effects on HL-60 cell differentiation
18. Insights into the molecular pathophysiology of chronic myeloid leukemia: Targets for therapeutic strategies?
19. Cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies
20. Role of cAMP receptor proteins in growth, differentiation, and suppression of malignancy: New approaches to therapy
21. A retinoid "resistant" t(15;17) acute promyelocytic leukemia cell line: Isolation, morphological, immunological, and molecular features
22. Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethyl sulfoxide
23. Increased levels of tissue factor mRNA in mononuclear blood cells of patiens with primary antiphospholipid syndrome
24. Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors
25. Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug resistant P388 murine leukaemia cells
26. Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase
27. 2+ increase and arachidonic acid release in FRTL-5 thyroid cells
28. + channels in myelinated nerve fibers of Xenopus laevis
29. Thyroid hormones in tissues from fetal and adult rats
30. Protein kinase C contains a pseudosubstrate prototype in its regulatory domain
31. Cancer procoagulant and tissue factor are differently modulated by all-trans-retinoic acid in acute promyelocytic leukemia cells
32. Relationship between differentiation mechanisms involving cAMP-dependent protein kinase and protein kinase C in uninduced and differentiating HL-60 cells
33. Differential changes of retinoid-X-receptor (RXRα) and its RARα and PML-RARα partners induced by retinoic acid and cAMP distinguish maturation sensitive and resistant t(15;17) promyelocytic leukemia NB4 cells