Clonidine and dexmedetomidine potently inhibit peristalsis in the guinea pig ileum in vitro

Anesthesiology

Volumn 97, Issue 6, 2002, Pages 1491-1499

  Herbert, Michael K ^a   Roth Goldbrunner, Susanne ^a   Holzer, Peter ^b   Roewer, Norbert ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; APAMIN; CALCIUM; CLONIDINE; DEXMEDETOMIDINE; N(G) NITRO DEXTRO ARGININE METHYL ESTER; N(G) NITROARGININE METHYL ESTER; NALOXONE; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNEL; PRAZOSIN; YOHIMBINE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENANTIOMER; FEMALE; ILEUM; INTENSIVE CARE UNIT; MALE; NONHUMAN; PERFUSION; PERISTALSIS; PRIORITY JOURNAL; SEDATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CLONIDINE; DEXMEDETOMIDINE; FEMALE; GUINEA PIGS; ILEUM; MALE; PERISTALSIS;

EID: 0036895023     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200212000-00022     Document Type: Article

References (49)

1. Van der Hulst RR, von Meyenfeldt MF, van Kreel BK, Thunnissen FB, Brummer RJ, Arends JW, Soeters PB: Gut permeability, intestinal morphology, and nutritional depletion. Nutrition 1998; 14:1-6
2. Kompan L, Kremzar B, Gadzijev E, Prosek M: Effects of early enteral nutrition on intestinal permeability and the development of multiple organ failure after multiple injury. Intensive Care Med 1999; 25:157-61
3. 2-adrenergic agonists. Anesthesiology 2000; 93:1345-9
4. 2 adrenergic receptor. Anesthesiology 1988; 69:818-22
5. Aho M, Lehtinen AM, Erkola O, Kallio A, Korttila K: The effect of intravenously administered dexmedetomidine on perioperative hemodynamics and isoflurane requirements in patients undergoing abdominal hysterectomy. Anesthesiology 1991; 74:997-1002
6. Hall JE, Uhrich TD, Barney JA, Arain SR, Ebert TJ: Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg 2000; 90:699-705
7. Ghignone M, Calvillo O, Quintin L: Anesthesia and hypertension: The effect of clonidine on perioperative hemodynamics and isoflurane requirements. Anesthesiology 1987; 67:3-10
8. Engelman E, Lipszyc M, Gilbart E, Van-der-Linden P, Bellens B, VanRomphey A, de-Rood M: Effects of clonidine on anesthetic drug requirements and hemodynamic response during aortic surgery. Anesthesiology 1989; 71:178-87
9. Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thorborg P, Heard S, Cheung A, Son SL, Kallio A: The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg 2000; 90:834-9
10. Virtanen R, Savola JM, Saano V, Nyman L: Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol 1988; 150:9-1
11. Asai T, Mapleson WW, Power I: Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat. Br J Anaesth 1997; 78:301-7
12. Puig MM, Pol O, Warner W: Interaction of morphine and clonidine on gastrointestinal transit in mice. Anesthesiology 1996; 85:1403-12
13. Puig MM, Warner W, Pol O: Intestinal inflammation and morphine tolerance alter the interaction between morphine and clonidine ance on gastrointestinal transit in mice. Anesthesiology 2000; 93:219-30
14. Gregersen H, Kraglund K, Rittig S, Tottrup A: The effect of a new selective alpha 2-adrenoceptor antagonist, idazoxan, and the agonist, clonidine, on fasting antroduodenal motility in healthy volunteers. Aliment Pharmacol Ther 1989; 3:435-43
15. Rubinoff MJ, Piccione PR, Holt, PR: Clonidine prolongs human small intestine transit time: Use of the lactulose-breath hydrogen test. Am J Gastroenterol 1989; 84:372-4
16. Bauer GE, Hellestrand KJ: Pseudo-obstruction due to clonidine (short report). BMJ 1976; 1:769
17. Bear R, Steer K: Pseudo-obstruction due to clonidine (letter). BMJ 1976; 1:197
18. Stieger DS, Cantieni R, Frutiger A: Acute colonic pseudoobstruction (Ogilvie's syndrome) in two patients receiving high dose clonidine for delirium tremens. Intensive Care Med 1997; 23:780-2
19. Holzer P, Maggi CA: Synergistic role of muscarinic acetylcholine and tachykinin NK-2 receptors in intestinal peristalsis. Naunyn Schmiedebergs Arch Pharmacol 1994; 349:194-201
20. Holzer P, Lippe IT, Heinemann A, Bartho L: Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro. Neuropharmacology 1998; 37:131-8
21. Tallarida RJ, Murray RB: Manual of Pharmacologic Calculation with Computer Programs. New York, Springer 1987, pp 26-31
22. De Ponti F, Gisaroni C. Cosentino M, Lecchini S, Frigo G: Adrenergic mechanisms in the control of gastrointestinal motility: From basic science to clinical applications. Pharmacol Ther 1996; 69:59-78
23. Furness, JB, Costa, M: The Enteric Nervous System Edinburgh, Churchill Livingstone, 1987, pp 137-189
24. Waterman SA, Tonini M, Costa M: The role of ascending excitatory and descending inhibitory pathways in peristalsis in the isolated guinea-pig small intestine. J Physiol 1994; 481:223-32
25. Costa M, Furness JB, Humphreys CMS: Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea-pig gastrointestinal tract. Naunyn Schmiedebergs Arch Pharmacol 1986; 332:79-88
26. Furness JB: Types of neurons in the enteric nervous system. J Auton Nerv Syst 2000; 81:87-96
27. Costa M, Furness JB, Pompolo S, Brookes SJH, Bornstein JC, Bredt DS, Snyder SH: Projections and chemical coding of neurons with immunoreactivity for nitric oxide synthase in the guinea-pig small intestine. Neurosci Lett 1992; 148:121-5
28. Lyster DJK, Bywater RA, Taylor GS, Watson MJ: Effects of a nitric oxide synthase inhibitor on non-cholinerglc junction potentials in the circular muscle of the guinea pig ileum. J Auton Nerv Syst 1992; 41:187-96
29. Baxter AJ, Edwards CA, Holden S, Cunningham KM, Welch IM, Read NW: The effect of two alpha 2-adrenoreceptor agonists and an antagonist on gastric emptying and mouth to caecum transit time in humans. Aliment Pharmacol Ther 1987; 1:649-55
30. Morali GA, Braveman DZ, Lissi J, Goldstein R, Jacobsohn WZ: Effect of clonidine on gallbladder contraction and small bowel transit time in insulintreated diabetics. Am J Gastroenterol 1991; 86:995-9
31. Pressman JH, Hofmann AF, Witztum KF, Gertler SL, Steinbach JH, Stokes K, Kelts DG, Stone DM, Jones BR, Dharmsathaphorn K: Limitations of indirect methods of estimating small bowel transit in man. Dig Dis Sci 1987; 32:689-99
32. Allescher HD, Ahmad S, Kostolanska F, Kwan CY, Daniel EE: Modulation of pyloric motor activity via adrenergic receptors. J Pharmacol Exp Ther 1989; 249:652-9
33. Ruwart MJ, Klepper MS, Rush BD: Clonidine delays small intestinal transit in the rat. J Pharmacol Exp Ther 1980; 212:487-90
34. Feldman M, Smith HJ, Simon TR: Gastric emptying of solid radiopaque markers: Studies in healthy subjects and diabetic patients. Gastroenterology 1984; 87:895-902
35. Houghton LA, Read NW, Heddle R, Horowitz M, Collins PJ, Chatterton B, Dent J: Relationship of the motor activity of the antrum, pylorus, and duodenum to gastric emptying of a solid-liquid mixed meal. Gastroenterology 1988; 94:1285-91
36. 2-adrenergic receptor regulation of ion transport in rabbit ileum. Am J Physiol 1982; 242:G237-42
37. Schiller LR, Santa-Ana CA, Morawski SG, Fordtran JS: Studies of the antidiarrheal action of clonidine: Effects on motility and intestinal absorption. Gastroenterology 1985; 89:982-81
38. Khan ZP, Ferguson CN, Jones RM: Alpha-2 and imidazoline receptor agonists: Their pharmacology and therapeutic role. Anaesthesia 1999; 54:146-65
39. Colucci R, Blandizzi C, Carignani D, Placanica G, Lazzeri G, Del Tacca M: Effects of imidazoline derivatives on cholinergic motility in guinea-pig ileum: Involvement of presynaptic alpha2-adrenoceptors or imidazoline receptors? Naunyn Schmiedebergs Arch Pharmacol 1998; 357:682-91
40. Eisenach J, Detweiler D, Hood D: Hemodynamic and analgesic actions of epidurally administered clonidine. Anesthesiology 1993; 78:277-87
41. Bol CJ, Vogelaar JP, Mandema JW: Anesthetic profile of dexmedetomidine identified by stimulus-response and continuous measurements in rats. J Pharmacol Exp Ther 1999; 291:153-60
42. Fargeas M-J, Fioramonti J, Bueno L: Central alpha 2-adrenergic control of the pattern of small intestinal motility. Gastroenterology 1986; 91:1470-5
43. Jiang Q, Sheldon RJ, Porreca F: Site of clonidine action to inhibit gut propulsion in mice: Demonstration of a central component. Gastroenterology 1988; 95:1265-71
44. Banks BEC, Brown C, Burgess GM, Burnstock G, Claret M, Cocks TM, Jenkinson DH: Apamin blocks certain neurotransmitter-induced increases in potassium permeability. Nature 1979; 282:415-7
45. Bywater RAR, Taylor GS: Non-cholinergic excitatory and inhibitory junction potentials in the circular smooth muscle of the guinea-pig ileum. J Physiol (Lond) 1986; 374:153-64
46. Liu L, Coupar IM: Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities. Naunyn Schmiedebergs Arch Pharmacol 1997; 356:248-56
47. Holzer P, Lippe IT, Tabrizi AL, Lenard L, Bartho L: Dual excitatory and inhibitory effect of nitric oxide on peristalsis in the guinea pig intestine. J Pharmacol Exp Ther 1997; 280:154-61
48. Starke K: Alpha-adrenoceptor subclassification. Rev Physiol Biochem Pharmacol 1981; 88:199-236
49. Funk L, Trendelenburg AU, Limberger N, Starke K: Subclassification of presynaptic alpha 2-adrenoceptors: Alpha 2D-autoreceptors and alpha 2D-adrenoceptors modulating release of acetylcholine in guinea-pig ileum. Naunyn Schmiedebergs Arch Pharmacol 1995; 352:58-66