4D or not 4D - The emetogenic basis of PDE4 inhibitors uncovered?

Trends in Pharmacological Sciences

Volumn 23, Issue 12, 2002, Pages 548-

  Giembycz, Mark A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; PHOSPHODIESTERASE INHIBITOR; XYLAZINE;

ANESTHESIA; ASTHMA; BEHAVIOR; BINDING SITE; BRAIN; CHRONIC OBSTRUCTIVE LUNG DISEASE; IMMUNOCOMPETENT CELL; INTESTINE; MULTIGENE FAMILY; NAUSEA AND VOMITING; NOTE; PRIORITY JOURNAL; REFLEX; RESPIRATORY TRACT INFLAMMATION; VOMITING; WILD TYPE;

EID: 0036891154     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0165-6147(02)02089-8     Document Type: Note

References (2)

1. Robichaud A., et al. Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor-mediated anesthesia: a behavioural surrogate of emesis. J. Clin. Invest. 110:2002;1045-1052.
2. Robichaud A. PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway. Neuropharmacology. 40:2001;262-269.